Research Article

DOI :10.26650/eor.20197852   IUP :10.26650/eor.20197852    Full Text (PDF)

Evaluation of antioxidant and antimutagenic activities of aluminum chloride

Nurdan SaraçAysel Uğurİnci Rana Karaca

Hemostatic agents are used to control hemorrhage and the gingival crevicular fluid for dental applications. In this study; the antimutagenic and antioxidant activities of aluminum chloride (AlCl3), a topical hemostatic agent used especially in the fields of dermatology and dentistry, were determined. To our knowledge, this is the first study that investigates these properties. 

Materials and Methods 
The antioxidant activity was determined by DPPH free radical scavenging and β-carotene-linoleic acid bleaching assays. The antimutagenic activity was evaluated with the Ames Salmonella/ microsome mutagenicity test using Salmonella typhimurium TA98 and TA100 strains. 

Results The total antioxidant activity of AlCl3, determined by β-carotene bleaching assay was found to be 25.59 ± 2.55% and the DPPH scavenging activity of AlCl3 was determined as 17.49 ± 3.07%. AlCl3 showed not any mutagenicity at the tested concentrations by the AMES test used S. typhimurium TA98 and TA100. This drug demonstrated antimutagenic effects at the test concentrations and the strongest antimutagenic activity was observed on 1.25 mg·mL-1/plate concentration of AlCl3. 

Conclusion AlCl3 showed potent antimutagenic and antioxidant activities and these properties are significant for dentistry and dermatology. 

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Saraç, N., Uğur, A., & Karaca, İ.R. (2019). Evaluation of antioxidant and antimutagenic activities of aluminum chloride. European Oral Research, 53(2), 51-55.


Saraç N, Uğur A, Karaca İ R. Evaluation of antioxidant and antimutagenic activities of aluminum chloride. European Oral Research. 2019;53(2):51-55.


Saraç, N.; Uğur, A.; Karaca, İ.R. Evaluation of antioxidant and antimutagenic activities of aluminum chloride. European Oral Research, [Publisher Location], v. 53, n. 2, p. 51-55, 2019.

Chicago: Author-Date Style

Saraç, Nurdan, and Aysel Uğur and İnci Rana Karaca. 2019. “Evaluation of antioxidant and antimutagenic activities of aluminum chloride.” European Oral Research 53, no. 2: 51-55.

Chicago: Humanities Style

Saraç, Nurdan, and Aysel Uğur and İnci Rana Karaca. Evaluation of antioxidant and antimutagenic activities of aluminum chloride.” European Oral Research 53, no. 2 (Jul. 2024): 51-55.

Harvard: Australian Style

Saraç, N & Uğur, A & Karaca, İR 2019, 'Evaluation of antioxidant and antimutagenic activities of aluminum chloride', European Oral Research, vol. 53, no. 2, pp. 51-55, viewed 20 Jul. 2024,

Harvard: Author-Date Style

Saraç, N. and Uğur, A. and Karaca, İ.R. (2019) ‘Evaluation of antioxidant and antimutagenic activities of aluminum chloride’, European Oral Research, 53(2), pp. 51-55. (20 Jul. 2024).


Saraç, Nurdan, and Aysel Uğur and İnci Rana Karaca. Evaluation of antioxidant and antimutagenic activities of aluminum chloride.” European Oral Research, vol. 53, no. 2, 2019, pp. 51-55. [Database Container],


Saraç N, Uğur A, Karaca İR. Evaluation of antioxidant and antimutagenic activities of aluminum chloride. European Oral Research [Internet]. 20 Jul. 2024 [cited 20 Jul. 2024];53(2):51-55. Available from: doi: 10.26650/eor.20197852


Saraç, Nurdan - Uğur, Aysel - Karaca, İnciRana. Evaluation of antioxidant and antimutagenic activities of aluminum chloride”. European Oral Research 53/2 (Jul. 2024): 51-55.


Published Online05.05.2019


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