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DOI :10.17096/jiufd.42354   IUP :10.17096/jiufd.42354    Full Text (PDF)

LEVELS OF LL-37 ANTIMICROBIAL PEPTIDE IN THE GINGIVAL CREVICULAR FLUID OF YOUNG AND MIDDLE-AGED SUBJECTS WITH OR WITHOUT GINGIVITIS

Oya Türkoğlu, Gülnur Emingil, Gülnihal Eren, Harika Atmaca, Necil Kütükcüler, Gül Atilla

Purpose: LL-37 is an antimicrobial peptide which plays an important role in the innate immunity. The aim of this study was to investigate the LL-37 levels in the gingival crevicular fluid (GCF) of middle-aged and young adults who have either gingivitis or healthy periodontal tissues. 

Materials and Methods: Forty middle-aged adults (20 healthy controls and 20 with gingivitis) and 41 younger adults (20 healthy controls and 21 with gingivitis) were included in the present study. Probing depth, clinical attachment level, plaque index, and papilla bleeding index were recorded. LL-37 levels in the GCF were analyzed by enzyme-linked immunosorbent assay. 

Results: No significant differences were observed in the GCF LL-37 levels between young healthy and middleaged healthy subjects. Also, there were no significant differences in GCF LL-37 levels between young and middle-aged gingivitis subjects. However, gingivitis groups had significantly higher GCF LL-37 levels than healthy groups (p< 0.001). Correlation analysis demonstrated no significant correlation between age and GCF LL37 levels neither in healthy nor in gingivitis groups. 

Conclusion: The levels of LL-37 in GCF increase in the presence of gingival inflammation, however, this does not vary according to subjects being young or middle-aged.
Keywords: Cathelicidin LL-37, antimicrobial peptide, gingival crevicular fluid, gingivitis, age
DOI :10.17096/jiufd.42354   IUP :10.17096/jiufd.42354    Full Text (PDF)

Gingivitisin Genç ve Orta Yaşlı Bireylerde Dişeti Oluğu Sıvısı LL-37 Seviyelerine Etkisi

Oya Türkoğlu, Gülnur Emingil, Gülnihal Eren, Harika Atmaca, Necil Kütükcüler, Gül Atilla

Amaç: Bir antimikrobiyal peptid olan LL-37 doğal immunitede önemli rol oynar. Bu çalışmanın amacı gingivitis tanısı almış ya da sağlıklı dişetlerine sahip olan genç ve orta yaşlı erişkin hastalarda dişeti oluk sıvısındaki (DOS) LL-37 seviyelerini incelemektir.

Gereç ve Yöntem: Bu çalışmaya 40 orta yaşlı erişkin (20 sağlıklı kontrol ve 20 gingivitisli) ve 41 genç erişkin (20 sağlıklı kontrol ve 21 gingivitisli) hasta dâhil edilmiştir. Sondalama derinliği, klinik ataşman seviyesi, plak indeksi ve papilla kanama indeksi değerleri kaydedilmiştir. DOS LL-37 seviyeleri enzim bağlı immunoabsorbent testi ile ölçülmüştür.

Bulgular: Dişetleri sağlıklı olan genç ve orta yaşlı bireylerin LL-37 seviyeleri arasında bir farklılık izlenmedi. Benzer şekilde gingivitisli genç ve orta yaşlı erişkinlerde DOS LL-37 seviyeleri arasında da fark gözlenmedi. Her iki gingivitis grubu sağlıklı kontrol gruplarına göre daha yüksek DOS LL-37 seviyesine sahipti (p< 0.05). Gerek sağlıklı gerekse gingivitisli gruplarda yaş ve DOS LL-37 seviyeleri arasında anlamlı bir ilişki saptanmadı.

Sonuç: Dişetinde enflamasyonun varlığı DOS’ta LL-37 seviyesinin artmasına sebep olmaktadır. Ancak hastanın genç ya da orta yaşlı erişkin bir birey olmasının bu durum üzerinde bir etkisi yoktur.
Keywords: Katelisidin LL-37, antimikrobiyalpeptid, dişeti oluğu sıvısı, gingivitis, yaş

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APA

Türkoğlu, O., Emingil, G., Eren, G., Atmaca, H., Kütükcüler, N., & Atilla, G. (2017). LEVELS OF LL-37 ANTIMICROBIAL PEPTIDE IN THE GINGIVAL CREVICULAR FLUID OF YOUNG AND MIDDLE-AGED SUBJECTS WITH OR WITHOUT GINGIVITIS. European Oral Research, 51(1), 15-21. https://doi.org/10.17096/jiufd.42354


AMA

Türkoğlu O, Emingil G, Eren G, Atmaca H, Kütükcüler N, Atilla G. LEVELS OF LL-37 ANTIMICROBIAL PEPTIDE IN THE GINGIVAL CREVICULAR FLUID OF YOUNG AND MIDDLE-AGED SUBJECTS WITH OR WITHOUT GINGIVITIS. European Oral Research. 2017;51(1):15-21. https://doi.org/10.17096/jiufd.42354


ABNT

Türkoğlu, O.; Emingil, G.; Eren, G.; Atmaca, H.; Kütükcüler, N.; Atilla, G. LEVELS OF LL-37 ANTIMICROBIAL PEPTIDE IN THE GINGIVAL CREVICULAR FLUID OF YOUNG AND MIDDLE-AGED SUBJECTS WITH OR WITHOUT GINGIVITIS. European Oral Research, [Publisher Location], v. 51, n. 1, p. 15-21, 2017.


Chicago: Author-Date Style

Türkoğlu, Oya, and Gülnur Emingil and Gülnihal Eren and Harika Atmaca and Necil Kütükcüler and Gül Atilla. 2017. “LEVELS OF LL-37 ANTIMICROBIAL PEPTIDE IN THE GINGIVAL CREVICULAR FLUID OF YOUNG AND MIDDLE-AGED SUBJECTS WITH OR WITHOUT GINGIVITIS.” European Oral Research 51, no. 1: 15-21. https://doi.org/10.17096/jiufd.42354


Chicago: Humanities Style

Türkoğlu, Oya, and Gülnur Emingil and Gülnihal Eren and Harika Atmaca and Necil Kütükcüler and Gül Atilla. “LEVELS OF LL-37 ANTIMICROBIAL PEPTIDE IN THE GINGIVAL CREVICULAR FLUID OF YOUNG AND MIDDLE-AGED SUBJECTS WITH OR WITHOUT GINGIVITIS.” European Oral Research 51, no. 1 (Dec. 2024): 15-21. https://doi.org/10.17096/jiufd.42354


Harvard: Australian Style

Türkoğlu, O & Emingil, G & Eren, G & Atmaca, H & Kütükcüler, N & Atilla, G 2017, 'LEVELS OF LL-37 ANTIMICROBIAL PEPTIDE IN THE GINGIVAL CREVICULAR FLUID OF YOUNG AND MIDDLE-AGED SUBJECTS WITH OR WITHOUT GINGIVITIS', European Oral Research, vol. 51, no. 1, pp. 15-21, viewed 22 Dec. 2024, https://doi.org/10.17096/jiufd.42354


Harvard: Author-Date Style

Türkoğlu, O. and Emingil, G. and Eren, G. and Atmaca, H. and Kütükcüler, N. and Atilla, G. (2017) ‘LEVELS OF LL-37 ANTIMICROBIAL PEPTIDE IN THE GINGIVAL CREVICULAR FLUID OF YOUNG AND MIDDLE-AGED SUBJECTS WITH OR WITHOUT GINGIVITIS’, European Oral Research, 51(1), pp. 15-21. https://doi.org/10.17096/jiufd.42354 (22 Dec. 2024).


MLA

Türkoğlu, Oya, and Gülnur Emingil and Gülnihal Eren and Harika Atmaca and Necil Kütükcüler and Gül Atilla. “LEVELS OF LL-37 ANTIMICROBIAL PEPTIDE IN THE GINGIVAL CREVICULAR FLUID OF YOUNG AND MIDDLE-AGED SUBJECTS WITH OR WITHOUT GINGIVITIS.” European Oral Research, vol. 51, no. 1, 2017, pp. 15-21. [Database Container], https://doi.org/10.17096/jiufd.42354


Vancouver

Türkoğlu O, Emingil G, Eren G, Atmaca H, Kütükcüler N, Atilla G. LEVELS OF LL-37 ANTIMICROBIAL PEPTIDE IN THE GINGIVAL CREVICULAR FLUID OF YOUNG AND MIDDLE-AGED SUBJECTS WITH OR WITHOUT GINGIVITIS. European Oral Research [Internet]. 22 Dec. 2024 [cited 22 Dec. 2024];51(1):15-21. Available from: https://doi.org/10.17096/jiufd.42354 doi: 10.17096/jiufd.42354


ISNAD

Türkoğlu, Oya - Emingil, Gülnur - Eren, Gülnihal - Atmaca, Harika - Kütükcüler, Necil - Atilla, Gül. “LEVELS OF LL-37 ANTIMICROBIAL PEPTIDE IN THE GINGIVAL CREVICULAR FLUID OF YOUNG AND MIDDLE-AGED SUBJECTS WITH OR WITHOUT GINGIVITIS”. European Oral Research 51/1 (Dec. 2024): 15-21. https://doi.org/10.17096/jiufd.42354



TIMELINE


Accepted10.06.2016
Published Online02.01.2017

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