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DOI :10.26650/eor.20241248958   IUP :10.26650/eor.20241248958    Full Text (PDF)

Prophylactic and therapeutic effects of (6)–shogaol on alveolar bone loss in experimental periodontitis

Didem Bezirci, Meltem Karşıyaka Hendek, Gönen Özcan, Oğuz Kul, Tuğçe Anteplioğlu, Ebru Olgun

Purpose: (6)-Shogaol is the most prevalent bioactive compound in ginger. The aim of this study was to examine both the prophylactic and therapeutic effects of (6)-shogaol in an experimental periodontitis model.

Materials and Methods: Thirty-five male Wistar albino rats were divided into four groups. In the healthy group (n=5), no intervention was undertaken. In the periodontitis group (n=10), periodontitis was induced by ligature placement for 14 days. In the prophylaxis group (n=10), periodontitis was induced with ligature placement for 14 days, and during this time, 20 mg/kg/day of (6)-shogaol was administered via oral gavage. In the therapeutic group (n=10), periodontitis was induced with ligature placement for 14 days, and following the removal of the ligature, 20 mg/kg/day of (6)-shogaol was administered via oral gavage for 14 days. Alveolar bone loss was histometrically measured, and malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GP), nuclear factor kappa B (NF-κB), receptor activator of nuclear factor kappa B ligand (RANKL), and osteoprotegerin (OPG) were immunohistochemically analyzed.

Results: Alveolar bone loss was significantly lower in the healthy group than in the remaining groups, as well as in the therapeutic group than in the periodontitis group (p<0.001). RANKL/OPG was significantly higher in the periodontitis group compared to the remaining groups and in the prophylaxis group compared to the therapeutic group (p<0.001). MDA was significantly lower in the healthy group than in the remaining groups (p<0.001). SOD was significantly lower in the periodontitis group than in the prophylaxis and therapeutic groups (p=0.039 and p=0.042, respectively). GP was significantly lower in the healthy group than in the prophylaxis and therapeutic groups (p=0.031 and p=0.002, respectively).

Conclusion: The administration of (6)-shogaol modulated the RANKL/OPG balance and antioxidant status in rats with ligature-induced periodontitis.

Keywords: Experimental periodontitis, ginger, oxidative stress, RANKL/OPG, shogaol

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APA

Bezirci, D., Karşıyaka Hendek, M., Özcan, G., Kul, O., Anteplioğlu, T., & Olgun, E. (2024). Prophylactic and therapeutic effects of (6)–shogaol on alveolar bone loss in experimental periodontitis. European Oral Research, 58(1), 37-43. https://doi.org/10.26650/eor.20241248958


AMA

Bezirci D, Karşıyaka Hendek M, Özcan G, Kul O, Anteplioğlu T, Olgun E. Prophylactic and therapeutic effects of (6)–shogaol on alveolar bone loss in experimental periodontitis. European Oral Research. 2024;58(1):37-43. https://doi.org/10.26650/eor.20241248958


ABNT

Bezirci, D.; Karşıyaka Hendek, M.; Özcan, G.; Kul, O.; Anteplioğlu, T.; Olgun, E. Prophylactic and therapeutic effects of (6)–shogaol on alveolar bone loss in experimental periodontitis. European Oral Research, [Publisher Location], v. 58, n. 1, p. 37-43, 2024.


Chicago: Author-Date Style

Bezirci, Didem, and Meltem Karşıyaka Hendek and Gönen Özcan and Oğuz Kul and Tuğçe Anteplioğlu and Ebru Olgun. 2024. “Prophylactic and therapeutic effects of (6)–shogaol on alveolar bone loss in experimental periodontitis.” European Oral Research 58, no. 1: 37-43. https://doi.org/10.26650/eor.20241248958


Chicago: Humanities Style

Bezirci, Didem, and Meltem Karşıyaka Hendek and Gönen Özcan and Oğuz Kul and Tuğçe Anteplioğlu and Ebru Olgun. “Prophylactic and therapeutic effects of (6)–shogaol on alveolar bone loss in experimental periodontitis.” European Oral Research 58, no. 1 (May. 2024): 37-43. https://doi.org/10.26650/eor.20241248958


Harvard: Australian Style

Bezirci, D & Karşıyaka Hendek, M & Özcan, G & Kul, O & Anteplioğlu, T & Olgun, E 2024, 'Prophylactic and therapeutic effects of (6)–shogaol on alveolar bone loss in experimental periodontitis', European Oral Research, vol. 58, no. 1, pp. 37-43, viewed 1 May. 2024, https://doi.org/10.26650/eor.20241248958


Harvard: Author-Date Style

Bezirci, D. and Karşıyaka Hendek, M. and Özcan, G. and Kul, O. and Anteplioğlu, T. and Olgun, E. (2024) ‘Prophylactic and therapeutic effects of (6)–shogaol on alveolar bone loss in experimental periodontitis’, European Oral Research, 58(1), pp. 37-43. https://doi.org/10.26650/eor.20241248958 (1 May. 2024).


MLA

Bezirci, Didem, and Meltem Karşıyaka Hendek and Gönen Özcan and Oğuz Kul and Tuğçe Anteplioğlu and Ebru Olgun. “Prophylactic and therapeutic effects of (6)–shogaol on alveolar bone loss in experimental periodontitis.” European Oral Research, vol. 58, no. 1, 2024, pp. 37-43. [Database Container], https://doi.org/10.26650/eor.20241248958


Vancouver

Bezirci D, Karşıyaka Hendek M, Özcan G, Kul O, Anteplioğlu T, Olgun E. Prophylactic and therapeutic effects of (6)–shogaol on alveolar bone loss in experimental periodontitis. European Oral Research [Internet]. 1 May. 2024 [cited 1 May. 2024];58(1):37-43. Available from: https://doi.org/10.26650/eor.20241248958 doi: 10.26650/eor.20241248958


ISNAD

Bezirci, Didem - Karşıyaka Hendek, Meltem - Özcan, Gönen - Kul, Oğuz - Anteplioğlu, Tuğçe - Olgun, Ebru. “Prophylactic and therapeutic effects of (6)–shogaol on alveolar bone loss in experimental periodontitis”. European Oral Research 58/1 (May. 2024): 37-43. https://doi.org/10.26650/eor.20241248958



TIMELINE


Submitted08.02.2023
Accepted09.05.2023
Published Online10.11.2023

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