Review Article


DOI :10.17096/jiufd.53911   IUP :10.17096/jiufd.53911    Full Text (PDF)

A REVIEW OF REGENERATIVE ENDODONTICS: CURRENT PROTOCOLS AND FUTURE DIRECTIONS

Louis m. LınBill Kahler

This review outlines the biological basis and clinical protocols currently used in regenerative endodontic procedures (REPs) and discuss future directions in pulp regeneration approaches. The treatment of immature teeth with REPs has been described as a ‘paradigm shift’ as there is the potential for further root maturation. Clinically, REPs involve disinfection of the root canal system without damaging the endogenous stem cell potential present in the apical papilla and other tissues. These stems cells are introduced into the root canal space by inducing a blood clot followed by placement of an intracanal barrier to prevent microleakage. The biological concept of REPs involves the triad of stem cells, scaffold and signalling molecules. Currently, repair rather than true regeneration of the ‘pulp-dentine complex’ is achieved and further root maturation is variable. However, may clinicians consider the treatment of teeth with REPs as the optimal treatment approach for immature teeth with pulp necrosis.

DOI :10.17096/jiufd.53911   IUP :10.17096/jiufd.53911    Full Text (PDF)

Rejeneratif Endodonti Üzerine Bir Derleme: Güncel Protokoller ve Geleceğe Yönelik Öneriler

Louis m. LınBill Kahler

Bu derlemede rejeneratif endodontik tedavinin biyolojik temelleri ve güncel klinik protokolleri anlatılmakta ve pulpa rejenerasyonu yaklaşımlarının geleceği tartışılmaktadır. Kök ucu kapanmamış dişlerin rejeneratif endodontik tedavi ile kök gelişiminin devam etme potansiyeli köklü bir değişim yaratmıştır. Klinik olarak rejeneratif endodontik tedavi apikal papilla ve diğer dokularda bulunan endojen kök hücrelere zarar vermeden kök kanalı sisteminin dezenfeksiyonunu içerir. Bu kök hücrelerin kan pıhtısı oluşturulması ile kök kanalı içine taşınmasını takiben mikrosızıntıyı önleme amacıyla kanal içine bariyer malzemesi yerleştirilir. Rejeneratif endodontik tedavinin biyolojik prensibi kök hücreler, doku iskeleleri ve sinyal molekülleri triadından oluşur. Günümüzde, “pulpa-dentin kompleksi” nin gerçek rejenerasyonundan ziyade tamir gerçekleşmektedir ve kök gelişiminin tamamlanması ise değişkenlik göstermektedir. Ancak, birçok klinisyen pulpası nekroze kök gelişimi tamamlanmamış dişlerde en uygun tedavinin rejeneratif endodontik yaklaşımlarla sağlanabileceğini düşünmektedir.


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APA

Lın, L., & Kahler, B. (2017). A REVIEW OF REGENERATIVE ENDODONTICS: CURRENT PROTOCOLS AND FUTURE DIRECTIONS. European Oral Research, 51(3), 41-51. https://doi.org/10.17096/jiufd.53911


AMA

Lın L, Kahler B. A REVIEW OF REGENERATIVE ENDODONTICS: CURRENT PROTOCOLS AND FUTURE DIRECTIONS. European Oral Research. 2017;51(3):41-51. https://doi.org/10.17096/jiufd.53911


ABNT

Lın, L.; Kahler, B. A REVIEW OF REGENERATIVE ENDODONTICS: CURRENT PROTOCOLS AND FUTURE DIRECTIONS. European Oral Research, [Publisher Location], v. 51, n. 3, p. 41-51, 2017.


Chicago: Author-Date Style

Lın, Louis m., and Bill Kahler. 2017. “A REVIEW OF REGENERATIVE ENDODONTICS: CURRENT PROTOCOLS AND FUTURE DIRECTIONS.” European Oral Research 51, no. 3: 41-51. https://doi.org/10.17096/jiufd.53911


Chicago: Humanities Style

Lın, Louis m., and Bill Kahler. A REVIEW OF REGENERATIVE ENDODONTICS: CURRENT PROTOCOLS AND FUTURE DIRECTIONS.” European Oral Research 51, no. 3 (May. 2024): 41-51. https://doi.org/10.17096/jiufd.53911


Harvard: Australian Style

Lın, L & Kahler, B 2017, 'A REVIEW OF REGENERATIVE ENDODONTICS: CURRENT PROTOCOLS AND FUTURE DIRECTIONS', European Oral Research, vol. 51, no. 3, pp. 41-51, viewed 5 May. 2024, https://doi.org/10.17096/jiufd.53911


Harvard: Author-Date Style

Lın, L. and Kahler, B. (2017) ‘A REVIEW OF REGENERATIVE ENDODONTICS: CURRENT PROTOCOLS AND FUTURE DIRECTIONS’, European Oral Research, 51(3), pp. 41-51. https://doi.org/10.17096/jiufd.53911 (5 May. 2024).


MLA

Lın, Louis m., and Bill Kahler. A REVIEW OF REGENERATIVE ENDODONTICS: CURRENT PROTOCOLS AND FUTURE DIRECTIONS.” European Oral Research, vol. 51, no. 3, 2017, pp. 41-51. [Database Container], https://doi.org/10.17096/jiufd.53911


Vancouver

Lın L, Kahler B. A REVIEW OF REGENERATIVE ENDODONTICS: CURRENT PROTOCOLS AND FUTURE DIRECTIONS. European Oral Research [Internet]. 5 May. 2024 [cited 5 May. 2024];51(3):41-51. Available from: https://doi.org/10.17096/jiufd.53911 doi: 10.17096/jiufd.53911


ISNAD

Lın, Louis m. - Kahler, Bill. A REVIEW OF REGENERATIVE ENDODONTICS: CURRENT PROTOCOLS AND FUTURE DIRECTIONS”. European Oral Research 51/3 (May. 2024): 41-51. https://doi.org/10.17096/jiufd.53911



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Submitted04.09.2017
Accepted10.10.2017

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