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Research Article


DOI :10.26650/eor.20190021   IUP :10.26650/eor.20190021    Full Text (PDF)

The effects of morus nigra on the alveolar bone loss in experimentally-induced periodontitis

Tuba Talo yildirim, Gonca Ozan, Serkan Dundar, Alihan Bozoglan, Tahir Karaman, Neval Dildes, Can Ayhan Kaya, Nalan Kaya, Elif Erdem

Purpose 
The aim of this study is to evalute the anti-inflammatory effects of morus migra on experimentally-induced periodontitis in rats. 

Materials and Methods 
Twenty-four Wistar-albino rats were randomly divided into three groups: control group (C, n=8), experimental periodontitis (PER, n=8), experimental periodontitis and treated with Morus nigra (MN+PER, n=8) (50 mg/kg per day for 21 days). After 21 days, the rats were sacrificed, and alveolar bones were evaluated histopathologically and histometrically analyzed to obtain level of alveolar bone loss. The detection of RANKL and OPG were immunohistochemically performed. Serum and tissue levels of MMP-8 and MMP-13 were also analyzed. 

Results 
Morus nigra treatment decreased tissue MMP-8 and MMP-13 levels and there were significant differences in the case of tissue levels of MMP-8 and MMP-13 between groups PER and MN+PER (p=0.035, p=0.041). There were no significant differences among all the groups serum levels of MMP-8 and MMP-13 (p=0.067, p=0.082). In the histometric evaluation, alveolar bone loss was greater in the PER group compared to C and MN groups (p=0.035). Immuno-histochemical staining of RANKL activities were found significantly lower (p=0.037) and OPG activities were found significantly higher in MN+PER group when compared to PER group (p=0.021). 

Conclusion 
The present study reveals that systemic administration of Morus nigra significantly inhibited the regional alveolar bone resorption and contributes to periodontal healing in the rat experimental-periodontitis models.
Keywords: Experimental periodontitis, cytokines, MMP-8, MMP-13, morus nigra

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APA

Talo yildirim, T., Ozan, G., Dundar, S., Bozoglan, A., Karaman, T., Dildes, N., Kaya, C.A., Kaya, N., & Erdem, E. (2019). The effects of morus nigra on the alveolar bone loss in experimentally-induced periodontitis. European Oral Research, 53(3), 99-105. https://doi.org/10.26650/eor.20190021


AMA

Talo yildirim T, Ozan G, Dundar S, Bozoglan A, Karaman T, Dildes N, Kaya C A, Kaya N, Erdem E. The effects of morus nigra on the alveolar bone loss in experimentally-induced periodontitis. European Oral Research. 2019;53(3):99-105. https://doi.org/10.26650/eor.20190021


ABNT

Talo yildirim, T.; Ozan, G.; Dundar, S.; Bozoglan, A.; Karaman, T.; Dildes, N.; Kaya, C.A.; Kaya, N.; Erdem, E. The effects of morus nigra on the alveolar bone loss in experimentally-induced periodontitis. European Oral Research, [Publisher Location], v. 53, n. 3, p. 99-105, 2019.


Chicago: Author-Date Style

Talo yildirim, Tuba, and Gonca Ozan and Serkan Dundar and Alihan Bozoglan and Tahir Karaman and Neval Dildes and Can Ayhan Kaya and Nalan Kaya and Elif Erdem. 2019. “The effects of morus nigra on the alveolar bone loss in experimentally-induced periodontitis.” European Oral Research 53, no. 3: 99-105. https://doi.org/10.26650/eor.20190021


Chicago: Humanities Style

Talo yildirim, Tuba, and Gonca Ozan and Serkan Dundar and Alihan Bozoglan and Tahir Karaman and Neval Dildes and Can Ayhan Kaya and Nalan Kaya and Elif Erdem. “The effects of morus nigra on the alveolar bone loss in experimentally-induced periodontitis.” European Oral Research 53, no. 3 (Nov. 2024): 99-105. https://doi.org/10.26650/eor.20190021


Harvard: Australian Style

Talo yildirim, T & Ozan, G & Dundar, S & Bozoglan, A & Karaman, T & Dildes, N & Kaya, CA & Kaya, N & Erdem, E 2019, 'The effects of morus nigra on the alveolar bone loss in experimentally-induced periodontitis', European Oral Research, vol. 53, no. 3, pp. 99-105, viewed 22 Nov. 2024, https://doi.org/10.26650/eor.20190021


Harvard: Author-Date Style

Talo yildirim, T. and Ozan, G. and Dundar, S. and Bozoglan, A. and Karaman, T. and Dildes, N. and Kaya, C.A. and Kaya, N. and Erdem, E. (2019) ‘The effects of morus nigra on the alveolar bone loss in experimentally-induced periodontitis’, European Oral Research, 53(3), pp. 99-105. https://doi.org/10.26650/eor.20190021 (22 Nov. 2024).


MLA

Talo yildirim, Tuba, and Gonca Ozan and Serkan Dundar and Alihan Bozoglan and Tahir Karaman and Neval Dildes and Can Ayhan Kaya and Nalan Kaya and Elif Erdem. “The effects of morus nigra on the alveolar bone loss in experimentally-induced periodontitis.” European Oral Research, vol. 53, no. 3, 2019, pp. 99-105. [Database Container], https://doi.org/10.26650/eor.20190021


Vancouver

Talo yildirim T, Ozan G, Dundar S, Bozoglan A, Karaman T, Dildes N, Kaya CA, Kaya N, Erdem E. The effects of morus nigra on the alveolar bone loss in experimentally-induced periodontitis. European Oral Research [Internet]. 22 Nov. 2024 [cited 22 Nov. 2024];53(3):99-105. Available from: https://doi.org/10.26650/eor.20190021 doi: 10.26650/eor.20190021


ISNAD

Talo yildirim, Tuba - Ozan, Gonca - Dundar, Serkan - Bozoglan, Alihan - Karaman, Tahir - Dildes, Neval - Kaya, CanAyhan - Kaya, Nalan - Erdem, Elif. “The effects of morus nigra on the alveolar bone loss in experimentally-induced periodontitis”. European Oral Research 53/3 (Nov. 2024): 99-105. https://doi.org/10.26650/eor.20190021



TIMELINE


Submitted31.08.2018
Accepted25.01.2019
Published Online10.09.2019

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