Case Report


DOI :10.17096/jiufd.880120   IUP :10.17096/jiufd.880120    Full Text (PDF)

TREATMENT OF GIANT CELL GRANULOMA WITH INTRALESIONAL CORTICOSTEROID INJECTIONS: A CASE REPORT

Özlem Filiz BayarGülsüm Ak

Giant cell granuloma is rare in the head and neck region and most commonly affects the maxilla and mandible. Giant cell granulomas are benign but occasionally aggressive lesions that are traditionally treated with surgery. Because it is a benign process,less radical and non-surgical treatment alternatives are required. Corticosteroid injection is a viable alternative in the treatment of central giant cell granuloma to avoid surgery. We aim to present acase which was successfully treated with intralesional corticosteroid injection in the maxilla.

DOI :10.17096/jiufd.880120   IUP :10.17096/jiufd.880120    Full Text (PDF)

DEV HÜCRELİ REPARATİF GRANULOMANIN İNTRALEZYONEL KORTİKOSTEROİD ENJEKSİYONU İLE TEDAVİSİ: OLGU SUNUMU

Özlem Filiz BayarGülsüm Ak

Dev Hücreli Reparatif Granuloma (DHRG)baş boyun bölgesinde nadir görülmekle birlikte genellikle maksilla ve mandibulayı etkiler. DHRG selim bir lezyondur ancak genellikle agresif olup tedavisi geleneksel olarak cerrahidir. Lezyonun selim karakteri nedeniyle daha az radikal olan ve cerrahi olmayan tedavi şekilleri tercih edilmektedir. DHRG tedavisinde cerrahiden kaçınıldığı durumlarda kortikosteroid enjeksiyonu alternatif bir tedavi olarak düşünülebilir. Bu yayında amacımız; maksillada intralezyonel kortikosteroid enjeksiyonu ile başarıyla tedavi ettiğimiz bir olgumuzu sunmaktır.


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References

  • Jaffe HL. Giant-cell reperative granuloma, traumatic bone cyst, and fibrous (fibro-osseous) dysplasia of the jawbones. Oral Surg Oral Med Oral Pathol 1953;6(1):159-175. google scholar
  • Regezi JA. Comments on pathogenesis and medical treatment of central giant cell granulomas. J Oral Maxillofac Surg 2004;62(1):116-118. google scholar
  • Barnes L, Eveson JW, Reichart P, Sidransky D (eds), Pathology and genetics of head and neck tumours. In: Kleihues P, Sobin LH (eds), World Health Organization classification of tumours. Lyon, France: IARC Press, 2005 google scholar
  • Cawson RA, Odell EW, Porter S. Cawson’s Essentials of Oral Pathology and Oral Medicine. Edinburg:Churchill Livingstone;Seventh edition.2002;139-141. google scholar
  • Miloro M, Quinn PD. Synchronous central giant cell lesions of the jaws: report of a case and review of the literature. J Oral Maxillofac Surg 1995;53(11):1350-1355. google scholar
  • Whitaker SB, Waldron CA. Central giant cell lesions of the jaws. A clinical, radiologic, and histopathologic study. Oral Surg Oral Med Oral Pathol 1993;75(2):199-208. google scholar
  • Chuong R, Kaban LB, Kozakewich H, Perez- Atayde A. Central giant cell lesions of the jaws: a clinicopathologic study. J Oral Maxillofac Surg 1986;44(9):708-713. google scholar
  • Gungormus M, Akgul HM. Central giant cell granuloma of the jaws: a clinical and radiological study. J Contemp Dent Pract 2003;4(3):87-97. google scholar
  • Tosco P, Tanteri G, Iaquinta C, Fasolis M, Roccia F, Berrone S, Garzino-Demo P. Surgical treatment and reconstruction for central giant cell granuloma of the jaws: a review of 18 cases. J Craniomaxillofac Surg 2009;37(7):380-387. google scholar
  • de Lange J, van den Akker HP, Klip H. Incidence and disease-free survival after surgical therapy of central giant cell granulomas of the jaw in The Netherlands: 1990-1995. Head Neck 2004;26(9):792-795. google scholar
  • Vered M, Buchner A, Dayan D. Immunohistochemical expression of glucocorticoid and calcitonin receptors as a tool for selecting therapeutic approach in central giant cell granuloma of the jawbones. Int J Oral Maxillofac Surg 2006;35(8):756–760. google scholar
  • Terry BC, Jacoway JR. Management of central giant cell lesion: an alternative to surgical therapy. Oral Maxillofac Surg Clin North Am 1994;6:579-600. google scholar
  • Sabanas AO, Dahlin DC, Childs DS Jr, Ivins JC. Postradiation sarcoma of bone. Cancer 1956;9(3):528-542. google scholar
  • Eisenbud L, Stern M, Rothberg M, Sachs SA. Central giant cell granuloma of the jaws: experiences in the management of thirty-seven cases. J Oral Maxillofac Surg 1988;46(5):376– 384. google scholar
  • Cheng YY, Huang L, Kumta SM, Lee KM, Lai FM, Tam JS. Cytochemical and ultrastructural changes in the osteoclast-like giant cells of giant cell tumor of bone following bisphosphonate administration. Ultrastruct Pathol 2003;27(6):385-391. google scholar
  • Kaban LB, Mulliken JB, Ezekowitz RA, Ebb D, Smith PS, Folkman J. Antiangiogenic therapy of a recurrent giant cell tumor of the mandible with interferon alpha-2a. Pediatrics 1999;103(6 Pt 1):1145-1149. google scholar
  • Kaban LB, Troulis MJ, Ebb D, August M, Hornicek FJ, Dodson TB. Antiangiogenic therapy with interferon alpha for giant cell lesions of the jaws. J Oral Maxillofac Surg 2002; 60(10):1103- 1111. google scholar
  • Harris M. Central giant cell granulomas of the jaws regress with calcitonin therapy. Br J Oral Maxillofac Surg 1993;31(2):89-94. google scholar
  • Allon DM, Anavi Y, Calderon S. Central giant cell lesion of the jaw: nonsurgical treatment with calcitonin nasal spray. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;107(6):811-818. google scholar
  • de Lange J, van den Akker HP, Veldhuijzen van Zanten GO, Engelshove HA, van den Berg H, Klip H. Calcitonin therapy in central giant cell granuloma of the jaw: a randomized double-blind placebo-controlled study. Int J Oral Maxillofac Surg 2006;35(9):791-795. google scholar
  • Pogrel MA, Regezi JA, Harris ST, Goldring SR. Calcitonin treatment for central giant cell granulomas of the mandible: report of two cases. J Oral Maxillofacial Surg 1999;57(7): 848-853. google scholar
  • Flanagan AM, Nui B, Tinkler SM, Horton MA, Williams DM, Chambers TJ. The multinucleate cells in giant cell granulomas of the jaw are osteoclasts. Cancer 1988;62(6): 1139-1145. google scholar
  • Jacoway JR, Howell FV, Terry BC. Central giant cell granuloma: an alternative to surgical therapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1988;66:572. google scholar
  • Kermer C, Millesi W, Watzke IM. Local injection of corticosteroids for central giant cell granuloma: a case report. Int J Oral Maxillofac Surg 1994;23(6 Pt 1):366-368. google scholar
  • Carlos R, Sedano HO. Intralesional corticosteroids as an alternative treatment for central giant cell granuloma. Oral Surg Oral Med Oral Pathol Orla Radiol Endod 2002;93(2): 161-166. google scholar
  • Kurtz M, Mesa M, Alberto P. Treatment of a central giant cell lesion of the mandible with intralesional glucocorticosteroids. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;91(6):636-637. google scholar
  • Rajeevan NS, Soumithran CS. Intralesional corticosteroid injection for central giant cell granuloma. A case report. Int J Oral Maxillofac Surg 1998;27(4):303-304. google scholar
  • Sezer B, Koyuncu B, Gomel M, Gunbay T. Intralesional corticosteroid injection for central giant cell granuloma: a case report and review of the literature. Turk J Pediatr 2005;47(1):75-81. google scholar

Citations

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APA

Bayar, Ö.F., & Ak, G. (0001). TREATMENT OF GIANT CELL GRANULOMA WITH INTRALESIONAL CORTICOSTEROID INJECTIONS: A CASE REPORT. European Oral Research, 49(3), 45-50. https://doi.org/10.17096/jiufd.880120


AMA

Bayar Ö F, Ak G. TREATMENT OF GIANT CELL GRANULOMA WITH INTRALESIONAL CORTICOSTEROID INJECTIONS: A CASE REPORT. European Oral Research. 0001;49(3):45-50. https://doi.org/10.17096/jiufd.880120


ABNT

Bayar, Ö.F.; Ak, G. TREATMENT OF GIANT CELL GRANULOMA WITH INTRALESIONAL CORTICOSTEROID INJECTIONS: A CASE REPORT. European Oral Research, [Publisher Location], v. 49, n. 3, p. 45-50, 0001.


Chicago: Author-Date Style

Bayar, Özlem Filiz, and Gülsüm Ak. 0001. “TREATMENT OF GIANT CELL GRANULOMA WITH INTRALESIONAL CORTICOSTEROID INJECTIONS: A CASE REPORT.” European Oral Research 49, no. 3: 45-50. https://doi.org/10.17096/jiufd.880120


Chicago: Humanities Style

Bayar, Özlem Filiz, and Gülsüm Ak. TREATMENT OF GIANT CELL GRANULOMA WITH INTRALESIONAL CORTICOSTEROID INJECTIONS: A CASE REPORT.” European Oral Research 49, no. 3 (Dec. 2024): 45-50. https://doi.org/10.17096/jiufd.880120


Harvard: Australian Style

Bayar, ÖF & Ak, G 0001, 'TREATMENT OF GIANT CELL GRANULOMA WITH INTRALESIONAL CORTICOSTEROID INJECTIONS: A CASE REPORT', European Oral Research, vol. 49, no. 3, pp. 45-50, viewed 22 Dec. 2024, https://doi.org/10.17096/jiufd.880120


Harvard: Author-Date Style

Bayar, Ö.F. and Ak, G. (0001) ‘TREATMENT OF GIANT CELL GRANULOMA WITH INTRALESIONAL CORTICOSTEROID INJECTIONS: A CASE REPORT’, European Oral Research, 49(3), pp. 45-50. https://doi.org/10.17096/jiufd.880120 (22 Dec. 2024).


MLA

Bayar, Özlem Filiz, and Gülsüm Ak. TREATMENT OF GIANT CELL GRANULOMA WITH INTRALESIONAL CORTICOSTEROID INJECTIONS: A CASE REPORT.” European Oral Research, vol. 49, no. 3, 0001, pp. 45-50. [Database Container], https://doi.org/10.17096/jiufd.880120


Vancouver

Bayar ÖF, Ak G. TREATMENT OF GIANT CELL GRANULOMA WITH INTRALESIONAL CORTICOSTEROID INJECTIONS: A CASE REPORT. European Oral Research [Internet]. 22 Dec. 2024 [cited 22 Dec. 2024];49(3):45-50. Available from: https://doi.org/10.17096/jiufd.880120 doi: 10.17096/jiufd.880120


ISNAD

Bayar, ÖzlemFiliz - Ak, Gülsüm. TREATMENT OF GIANT CELL GRANULOMA WITH INTRALESIONAL CORTICOSTEROID INJECTIONS: A CASE REPORT”. European Oral Research 49/3 (Dec. 2024): 45-50. https://doi.org/10.17096/jiufd.880120



TIMELINE


Submitted13.05.2014
Accepted04.07.2014

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