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DOI :10.26650/experimed.1461284   IUP :10.26650/experimed.1461284    Full Text (PDF)

Altered Tissue Factor Activity and Disrupted Oxidant-Antioxidant Status in Saliva of Patients with Oral Lichen Planus

Derya Cansız, Merih Beler, İsmail Ünal, Gizem Eğilmezer, Zülal Mızrak, Semanur Işıkoğlu, Efruz İrem Akkuş, Birsay Gümrü, Şebnem Erçalık Yalçınkaya, Ebru Emekli Alturfan

Objective: The aim of our study was to investigate salivary tissue factor (TF) activity and oxidant-antioxidant status, which is an important defense system, in saliva samples collected from patients with oral lichen planus (OLP), and to determine the relationship between the antioxidant system and TF activity in OLP.

Materials and Methods: Saliva samples were collected from patients with OLP (n=20) and healthy subjects (n=13). TF activity, lipid peroxidation (LPO), nitric oxide (NO), glutathione (GSH) levels, glutathione S-transferase (GST), and superoxide dismutase (SOD) activities were measured.

Results: NO levels and GST activities were increased, whereas GSH levels and SOD activities were decreased, when compared with healthy subjects in the saliva samples collected from patients with OLP. In addition, TF activity was increased in the OLP group compared with the control group.

Conclusion: The results revealed that the salivary oxidant-antioxidant balance was disrupted in parallel with the increase in TF activity in patients with OLP.

Keywords: Oral lichen planus, tissue factor, oxidative stress, saliva

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APA

Cansız, D., Beler, M., Ünal, İ., Eğilmezer, G., Mızrak, Z., Işıkoğlu, S., Akkuş, E.İ., Gümrü, B., Erçalık Yalçınkaya, Ş., & Emekli Alturfan, E. (2024). Altered Tissue Factor Activity and Disrupted Oxidant-Antioxidant Status in Saliva of Patients with Oral Lichen Planus. Experimed, 14(2), 85-91. https://doi.org/10.26650/experimed.1461284


AMA

Cansız D, Beler M, Ünal İ, Eğilmezer G, Mızrak Z, Işıkoğlu S, Akkuş E İ, Gümrü B, Erçalık Yalçınkaya Ş, Emekli Alturfan E. Altered Tissue Factor Activity and Disrupted Oxidant-Antioxidant Status in Saliva of Patients with Oral Lichen Planus. Experimed. 2024;14(2):85-91. https://doi.org/10.26650/experimed.1461284


ABNT

Cansız, D.; Beler, M.; Ünal, İ.; Eğilmezer, G.; Mızrak, Z.; Işıkoğlu, S.; Akkuş, E.İ.; Gümrü, B.; Erçalık Yalçınkaya, Ş.; Emekli Alturfan, E. Altered Tissue Factor Activity and Disrupted Oxidant-Antioxidant Status in Saliva of Patients with Oral Lichen Planus. Experimed, [Publisher Location], v. 14, n. 2, p. 85-91, 2024.


Chicago: Author-Date Style

Cansız, Derya, and Merih Beler and İsmail Ünal and Gizem Eğilmezer and Zülal Mızrak and Semanur Işıkoğlu and Efruz İrem Akkuş and Birsay Gümrü and Şebnem Erçalık Yalçınkaya and Ebru Emekli Alturfan. 2024. “Altered Tissue Factor Activity and Disrupted Oxidant-Antioxidant Status in Saliva of Patients with Oral Lichen Planus.” Experimed 14, no. 2: 85-91. https://doi.org/10.26650/experimed.1461284


Chicago: Humanities Style

Cansız, Derya, and Merih Beler and İsmail Ünal and Gizem Eğilmezer and Zülal Mızrak and Semanur Işıkoğlu and Efruz İrem Akkuş and Birsay Gümrü and Şebnem Erçalık Yalçınkaya and Ebru Emekli Alturfan. “Altered Tissue Factor Activity and Disrupted Oxidant-Antioxidant Status in Saliva of Patients with Oral Lichen Planus.” Experimed 14, no. 2 (Nov. 2024): 85-91. https://doi.org/10.26650/experimed.1461284


Harvard: Australian Style

Cansız, D & Beler, M & Ünal, İ & Eğilmezer, G & Mızrak, Z & Işıkoğlu, S & Akkuş, Eİ & Gümrü, B & Erçalık Yalçınkaya, Ş & Emekli Alturfan, E 2024, 'Altered Tissue Factor Activity and Disrupted Oxidant-Antioxidant Status in Saliva of Patients with Oral Lichen Planus', Experimed, vol. 14, no. 2, pp. 85-91, viewed 15 Nov. 2024, https://doi.org/10.26650/experimed.1461284


Harvard: Author-Date Style

Cansız, D. and Beler, M. and Ünal, İ. and Eğilmezer, G. and Mızrak, Z. and Işıkoğlu, S. and Akkuş, E.İ. and Gümrü, B. and Erçalık Yalçınkaya, Ş. and Emekli Alturfan, E. (2024) ‘Altered Tissue Factor Activity and Disrupted Oxidant-Antioxidant Status in Saliva of Patients with Oral Lichen Planus’, Experimed, 14(2), pp. 85-91. https://doi.org/10.26650/experimed.1461284 (15 Nov. 2024).


MLA

Cansız, Derya, and Merih Beler and İsmail Ünal and Gizem Eğilmezer and Zülal Mızrak and Semanur Işıkoğlu and Efruz İrem Akkuş and Birsay Gümrü and Şebnem Erçalık Yalçınkaya and Ebru Emekli Alturfan. “Altered Tissue Factor Activity and Disrupted Oxidant-Antioxidant Status in Saliva of Patients with Oral Lichen Planus.” Experimed, vol. 14, no. 2, 2024, pp. 85-91. [Database Container], https://doi.org/10.26650/experimed.1461284


Vancouver

Cansız D, Beler M, Ünal İ, Eğilmezer G, Mızrak Z, Işıkoğlu S, Akkuş Eİ, Gümrü B, Erçalık Yalçınkaya Ş, Emekli Alturfan E. Altered Tissue Factor Activity and Disrupted Oxidant-Antioxidant Status in Saliva of Patients with Oral Lichen Planus. Experimed [Internet]. 15 Nov. 2024 [cited 15 Nov. 2024];14(2):85-91. Available from: https://doi.org/10.26650/experimed.1461284 doi: 10.26650/experimed.1461284


ISNAD

Cansız, Derya - Beler, Merih - Ünal, İsmail - Eğilmezer, Gizem - Mızrak, Zülal - Işıkoğlu, Semanur - Akkuş, Efruzİrem - Gümrü, Birsay - Erçalık Yalçınkaya, Şebnem - Emekli Alturfan, Ebru. “Altered Tissue Factor Activity and Disrupted Oxidant-Antioxidant Status in Saliva of Patients with Oral Lichen Planus”. Experimed 14/2 (Nov. 2024): 85-91. https://doi.org/10.26650/experimed.1461284



TIMELINE


Submitted01.04.2024
Accepted24.05.2024
Published Online26.08.2024

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