Research Article


DOI :10.26650/experimed.1565962   IUP :10.26650/experimed.1565962    Full Text (PDF)

Could Increased Glp1r Expression via Sitagliptin in the GLP-1/GLP-1 Receptor Axis in the DietInduced Obesity Rat Model be Important in Liver Metabolism?

Neslihan ÇevikGülper NacarkahyaSerkan GürgülCem Horozoğlu

Objective: The aim of this study was to evaluate the contribution of sitagliptin, which is used in the treatment of type 2 diabetes mellitus due to its insulinotropic effects, to the levels of glucagon-like peptide-1 (GLP-1) expressed in many systemic tissues in obesity, in liver, skeletal muscle, and fat tissue.

Materials and Methods: Adult Wistar albino rats (n=32) were randomly divided into four groups for 16 weeks of intervention. These groups were control (C) (n=8), obese (Ob) (n=8), sitagliptin (C+Stg) (n=8), and obese (Ob+Stg) given sitagliptin (n=8). Glp1r expression in rat liver, muscle, and adipose tissue was confirmed by quantitative real-time PCR.

Results: No significant change was detected in Glp1r expression levels in muscle and fat tissue in 4 groups. A 10.64-fold increase in Glp1r gene expression was observed in Ob compared to C (p=0.008). Additionally, a 4.03-fold increase in expression level was found in Ob+Stg compared to Ob (p=0.02) and a 12.52-fold increase in expression level was found in Ob+Stg compared to C (p=0.01).

Conclusion: The increased Glp1r expression intensity in obese individuals using sitagliptin compared with controls and obese individuals not using sitagliptin may play a role in the reorganization of liver metabolism that is impaired due to obesity, such as the gluconeogenesis process.


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APA

Çevik, N., Nacarkahya, G., Gürgül, S., & Horozoğlu, C. (2024). Could Increased Glp1r Expression via Sitagliptin in the GLP-1/GLP-1 Receptor Axis in the DietInduced Obesity Rat Model be Important in Liver Metabolism?. Experimed, 14(3), 210-214. https://doi.org/10.26650/experimed.1565962


AMA

Çevik N, Nacarkahya G, Gürgül S, Horozoğlu C. Could Increased Glp1r Expression via Sitagliptin in the GLP-1/GLP-1 Receptor Axis in the DietInduced Obesity Rat Model be Important in Liver Metabolism?. Experimed. 2024;14(3):210-214. https://doi.org/10.26650/experimed.1565962


ABNT

Çevik, N.; Nacarkahya, G.; Gürgül, S.; Horozoğlu, C. Could Increased Glp1r Expression via Sitagliptin in the GLP-1/GLP-1 Receptor Axis in the DietInduced Obesity Rat Model be Important in Liver Metabolism?. Experimed, [Publisher Location], v. 14, n. 3, p. 210-214, 2024.


Chicago: Author-Date Style

Çevik, Neslihan, and Gülper Nacarkahya and Serkan Gürgül and Cem Horozoğlu. 2024. “Could Increased Glp1r Expression via Sitagliptin in the GLP-1/GLP-1 Receptor Axis in the DietInduced Obesity Rat Model be Important in Liver Metabolism?.” Experimed 14, no. 3: 210-214. https://doi.org/10.26650/experimed.1565962


Chicago: Humanities Style

Çevik, Neslihan, and Gülper Nacarkahya and Serkan Gürgül and Cem Horozoğlu. Could Increased Glp1r Expression via Sitagliptin in the GLP-1/GLP-1 Receptor Axis in the DietInduced Obesity Rat Model be Important in Liver Metabolism?.” Experimed 14, no. 3 (Dec. 2024): 210-214. https://doi.org/10.26650/experimed.1565962


Harvard: Australian Style

Çevik, N & Nacarkahya, G & Gürgül, S & Horozoğlu, C 2024, 'Could Increased Glp1r Expression via Sitagliptin in the GLP-1/GLP-1 Receptor Axis in the DietInduced Obesity Rat Model be Important in Liver Metabolism?', Experimed, vol. 14, no. 3, pp. 210-214, viewed 21 Dec. 2024, https://doi.org/10.26650/experimed.1565962


Harvard: Author-Date Style

Çevik, N. and Nacarkahya, G. and Gürgül, S. and Horozoğlu, C. (2024) ‘Could Increased Glp1r Expression via Sitagliptin in the GLP-1/GLP-1 Receptor Axis in the DietInduced Obesity Rat Model be Important in Liver Metabolism?’, Experimed, 14(3), pp. 210-214. https://doi.org/10.26650/experimed.1565962 (21 Dec. 2024).


MLA

Çevik, Neslihan, and Gülper Nacarkahya and Serkan Gürgül and Cem Horozoğlu. Could Increased Glp1r Expression via Sitagliptin in the GLP-1/GLP-1 Receptor Axis in the DietInduced Obesity Rat Model be Important in Liver Metabolism?.” Experimed, vol. 14, no. 3, 2024, pp. 210-214. [Database Container], https://doi.org/10.26650/experimed.1565962


Vancouver

Çevik N, Nacarkahya G, Gürgül S, Horozoğlu C. Could Increased Glp1r Expression via Sitagliptin in the GLP-1/GLP-1 Receptor Axis in the DietInduced Obesity Rat Model be Important in Liver Metabolism?. Experimed [Internet]. 21 Dec. 2024 [cited 21 Dec. 2024];14(3):210-214. Available from: https://doi.org/10.26650/experimed.1565962 doi: 10.26650/experimed.1565962


ISNAD

Çevik, Neslihan - Nacarkahya, Gülper - Gürgül, Serkan - Horozoğlu, Cem. Could Increased Glp1r Expression via Sitagliptin in the GLP-1/GLP-1 Receptor Axis in the DietInduced Obesity Rat Model be Important in Liver Metabolism?”. Experimed 14/3 (Dec. 2024): 210-214. https://doi.org/10.26650/experimed.1565962



TIMELINE


Submitted13.10.2024
Accepted02.12.2024
Published Online10.12.2024

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