Research Article


DOI :10.26650/experimed.1505817   IUP :10.26650/experimed.1505817    Full Text (PDF)

Determining Prostate Cancer-Related Pathways and the Role of the RPH3AL Gene

Didem SevenÖmer Faruk Bayrak

Objective: Prostate cancer is the fifth leading cause of death worldwide. Treatment modalities for advanced prostate cancer include androgen deprivation therapy (ADT), chemotherapy, radiotherapy, and targeted therapy. Transcriptomic profiling in prostate cancer enhances our understanding of the disease at the molecular level, facilitating more accurate diagnosis and personalized treatment choices, and ultimately improving patient outcomes. Identifying new therapeutic biomarkers for prostate cancer is important for developing targeted therapy options. This study aimed to elucidate the pathways associated with prostate cancer and identify differentially expressed genes.

Materials and Methods: An RNA-seq dataset, GSE210205, was used to reveal transcriptomic differences between prostate cancer and benign prostate cell lines. GEO2R analysis, GSEA analysis, WebGestalt analysis, and GEPIA analyses were performed to generate differentially expressed genes, identify enriched pathways, and investigate gene expression in prostate cancer.

Results: Pathways such as Wnt/β-catenin signaling, DNA IR-induced double-strand breaks, cellular response via ATM, Type II interferon signaling, and TGF-β signaling were enriched in the prostate cancer transcriptome. Among the five most over-expressed genes, RPH3AL was the most prominent.

Conclusion: RPH3AL is a potential biomarker for prostate cancer based on transcriptomic profiling. Further investigation is required to validate the role and potential of this agent as a therapeutic target.


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APA

Seven, D., & , Ö. (2024). Determining Prostate Cancer-Related Pathways and the Role of the RPH3AL Gene. Experimed, 14(3), 215-220. https://doi.org/10.26650/experimed.1505817


AMA

Seven D, Ö. Determining Prostate Cancer-Related Pathways and the Role of the RPH3AL Gene. Experimed. 2024;14(3):215-220. https://doi.org/10.26650/experimed.1505817


ABNT

Seven, D.; , Ö. Determining Prostate Cancer-Related Pathways and the Role of the RPH3AL Gene. Experimed, [Publisher Location], v. 14, n. 3, p. 215-220, 2024.


Chicago: Author-Date Style

Seven, Didem, and Ömer Faruk Bayrak . 2024. “Determining Prostate Cancer-Related Pathways and the Role of the RPH3AL Gene.” Experimed 14, no. 3: 215-220. https://doi.org/10.26650/experimed.1505817


Chicago: Humanities Style

Seven, Didem, and Ömer Faruk Bayrak . Determining Prostate Cancer-Related Pathways and the Role of the RPH3AL Gene.” Experimed 14, no. 3 (Dec. 2024): 215-220. https://doi.org/10.26650/experimed.1505817


Harvard: Australian Style

Seven, D & , Ö 2024, 'Determining Prostate Cancer-Related Pathways and the Role of the RPH3AL Gene', Experimed, vol. 14, no. 3, pp. 215-220, viewed 21 Dec. 2024, https://doi.org/10.26650/experimed.1505817


Harvard: Author-Date Style

Seven, D. and , Ö. (2024) ‘Determining Prostate Cancer-Related Pathways and the Role of the RPH3AL Gene’, Experimed, 14(3), pp. 215-220. https://doi.org/10.26650/experimed.1505817 (21 Dec. 2024).


MLA

Seven, Didem, and Ömer Faruk Bayrak . Determining Prostate Cancer-Related Pathways and the Role of the RPH3AL Gene.” Experimed, vol. 14, no. 3, 2024, pp. 215-220. [Database Container], https://doi.org/10.26650/experimed.1505817


Vancouver

Seven D, Ö. Determining Prostate Cancer-Related Pathways and the Role of the RPH3AL Gene. Experimed [Internet]. 21 Dec. 2024 [cited 21 Dec. 2024];14(3):215-220. Available from: https://doi.org/10.26650/experimed.1505817 doi: 10.26650/experimed.1505817


ISNAD

Seven, Didem - , Ömer Faruk Bayrak. Determining Prostate Cancer-Related Pathways and the Role of the RPH3AL Gene”. Experimed 14/3 (Dec. 2024): 215-220. https://doi.org/10.26650/experimed.1505817



TIMELINE


Submitted27.06.2024
Accepted06.12.2024
Published Online11.12.2024

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