Research Article

DOI :10.26650/experimed.1587358 IUP :10.26650/experimed.1587358 Full Text (PDF)

The Evaluation of Serum Total Tau, NFL, Neurogranin, YKL-40, and FABP-3 as Screening Biomarkers for Alzheimer’s Disease

Gözde Ceylan, Nazan Karagöz Sakallı, Hacer Eroğlu İçli, Canan Küçükgergin, Semra Doğru Abbasoğlu, Pervin Vural

Objective: Alzheimer’s disease (AD) is a neurodegenerative disorder that causes dementia and accounts for 50-75% of all cases. Since cerebrospinal fluid sampling (CSF) is an invasive procedure, there is a need for non- or less invasive alternatives to identify new biomarkers that reflect the underlying AD pathology.

Materials and Methods: Blood samples were obtained from 86 AD patients (33 mild, 29 moderate, and 24 severe AD) and 30 controls. Serum total tau, neurofilament light polypeptide (NFL), neurogranin, chitinase-3-like protein 1 (YKL-40), and fatty acid-binding protein 3 (FABP-3) were measured using enzymelinked immunosorbent assay (ELISA).

Results: Serum total tau and NFL levels were higher in AD patients compared to controls, whereas neurogranin, YKL-40, and FABP-3 levels remained unchanged. In the receiver operating characteristic (ROC) curve analysis, the sensitivity and specificity for total tau alone (cut-off point: 71.5 pg/mL) were 79.1% and 76.7% (Area under the curve (AUC): 0.865; p<0.001), while the sensitivity and specificity for NFL alone (cut-off point: 1.835 pg/mL) were 66.3% and 66.7% (AUC: 0.693; p=0.002). When total tau and NFL were concomitantly evaluated, the AUC was 0.848 (p<0.001).

Conclusion: Alongside the established core AD biomarkers, serum total tau and NFL are promising biomarkers for AD, reflecting additional pathological changes during the disease.

Keywords: Alzheimer’s disease, Serum, Biomarker, Tau, NFL, YKL-40, FABP-3

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APA

Ceylan, G., Karagöz Sakallı, N., Eroğlu İçli, H., Küçükgergin, C., Doğru Abbasoğlu, S., & Vural, P. (2020). The Evaluation of Serum Total Tau, NFL, Neurogranin, YKL-40, and FABP-3 as Screening Biomarkers for Alzheimer’s Disease. Experimed, 0(0), -. https://doi.org/10.26650/experimed.1587358

AMA

Ceylan G, Karagöz Sakallı N, Eroğlu İçli H, Küçükgergin C, Doğru Abbasoğlu S, Vural P. The Evaluation of Serum Total Tau, NFL, Neurogranin, YKL-40, and FABP-3 as Screening Biomarkers for Alzheimer’s Disease. Experimed. 2020;0(0):-. https://doi.org/10.26650/experimed.1587358

ABNT

Ceylan, G.; Karagöz Sakallı, N.; Eroğlu İçli, H.; Küçükgergin, C.; Doğru Abbasoğlu, S.; Vural, P. The Evaluation of Serum Total Tau, NFL, Neurogranin, YKL-40, and FABP-3 as Screening Biomarkers for Alzheimer’s Disease. Experimed, [Publisher Location], v. 0, n. 0, p. -, 2020.

Chicago: Author-Date Style

Ceylan, Gözde, and Nazan Karagöz Sakallı and Hacer Eroğlu İçli and Canan Küçükgergin and Semra Doğru Abbasoğlu and Pervin Vural. 2020. “The Evaluation of Serum Total Tau, NFL, Neurogranin, YKL-40, and FABP-3 as Screening Biomarkers for Alzheimer’s Disease.” Experimed 0, no. 0: -. https://doi.org/10.26650/experimed.1587358

Chicago: Humanities Style

Ceylan, Gözde, and Nazan Karagöz Sakallı and Hacer Eroğlu İçli and Canan Küçükgergin and Semra Doğru Abbasoğlu and Pervin Vural. “The Evaluation of Serum Total Tau, NFL, Neurogranin, YKL-40, and FABP-3 as Screening Biomarkers for Alzheimer’s Disease.” Experimed 0, no. 0 (Apr. 2025): -. https://doi.org/10.26650/experimed.1587358

Harvard: Australian Style

Ceylan, G & Karagöz Sakallı, N & Eroğlu İçli, H & Küçükgergin, C & Doğru Abbasoğlu, S & Vural, P 2020, 'The Evaluation of Serum Total Tau, NFL, Neurogranin, YKL-40, and FABP-3 as Screening Biomarkers for Alzheimer’s Disease', Experimed, vol. 0, no. 0, pp. -, viewed 3 Apr. 2025, https://doi.org/10.26650/experimed.1587358

Harvard: Author-Date Style

Ceylan, G. and Karagöz Sakallı, N. and Eroğlu İçli, H. and Küçükgergin, C. and Doğru Abbasoğlu, S. and Vural, P. (2020) ‘The Evaluation of Serum Total Tau, NFL, Neurogranin, YKL-40, and FABP-3 as Screening Biomarkers for Alzheimer’s Disease’, Experimed, 0(0), pp. -. https://doi.org/10.26650/experimed.1587358 (3 Apr. 2025).

MLA

Ceylan, Gözde, and Nazan Karagöz Sakallı and Hacer Eroğlu İçli and Canan Küçükgergin and Semra Doğru Abbasoğlu and Pervin Vural. “The Evaluation of Serum Total Tau, NFL, Neurogranin, YKL-40, and FABP-3 as Screening Biomarkers for Alzheimer’s Disease.” Experimed, vol. 0, no. 0, 2020, pp. -. [Database Container], https://doi.org/10.26650/experimed.1587358

Vancouver

Ceylan G, Karagöz Sakallı N, Eroğlu İçli H, Küçükgergin C, Doğru Abbasoğlu S, Vural P. The Evaluation of Serum Total Tau, NFL, Neurogranin, YKL-40, and FABP-3 as Screening Biomarkers for Alzheimer’s Disease. Experimed [Internet]. 3 Apr. 2025 [cited 3 Apr. 2025];0(0):-. Available from: https://doi.org/10.26650/experimed.1587358 doi: 10.26650/experimed.1587358

ISNAD

Ceylan, Gözde - Karagöz Sakallı, Nazan - Eroğlu İçli, Hacer - Küçükgergin, Canan - Doğru Abbasoğlu, Semra - Vural, Pervin. “The Evaluation of Serum Total Tau, NFL, Neurogranin, YKL-40, and FABP-3 as Screening Biomarkers for Alzheimer’s Disease”. Experimed 0/0 (Apr. 2025): -. https://doi.org/10.26650/experimed.1587358

TIMELINE

Submitted	19.11.2024
Accepted	04.03.2025
Published Online	20.03.2025

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