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Research Article


DOI :10.26650/IstanbulJPharm.2019.19002   IUP :10.26650/IstanbulJPharm.2019.19002    Full Text (PDF)

A new approach for the synthesis of N,N’- bis(phenoxyacetyl)hydrazines

Çağla Begüm Apaydın, Zafer Cesur

This report is about an unexpected formation of N,N’-bis(substituted phenoxyacetyl) hydrazine derivatives. The reaction between N’-(4-ethylcyclohexylidene)phenoxyacetohydrazide with sulfanyl acids to obtain 4-thiazolidinones s, gave an unexpected product, N,N’-bis(phenoxyacetyl)hydrazine, with high purity instead of the expected cyclocondensation product. When repeating the reaction with p-toluenesulfonic acid under the same conditions, the reaction resulted in the same compound. This indicates that two molecules of N’-(4-ethylcyclohexylidene)phenoxyacetohydrazide were involved in the reaction. The reaction can be applied as a different and new procedure for the synthesis of several N,N’-bis(substituted phenoxyacetyl) hydrazine derivatives.

Keywords: Diacylhydrazines, sulfanyl acid, reaction mechanism

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APA

Apaydın, Ç., & Cesur, Z. (0001). A new approach for the synthesis of N,N’- bis(phenoxyacetyl)hydrazines. İstanbul Journal of Pharmacy, 49(2), 61-63. https://doi.org/10.26650/IstanbulJPharm.2019.19002


AMA

Apaydın Ç, Cesur Z. A new approach for the synthesis of N,N’- bis(phenoxyacetyl)hydrazines. İstanbul Journal of Pharmacy. 0001;49(2):61-63. https://doi.org/10.26650/IstanbulJPharm.2019.19002


ABNT

Apaydın, Ç.; Cesur, Z. A new approach for the synthesis of N,N’- bis(phenoxyacetyl)hydrazines. İstanbul Journal of Pharmacy, [Publisher Location], v. 49, n. 2, p. 61-63, 0001.


Chicago: Author-Date Style

Apaydın, Çağla Begüm, and Zafer Cesur. 0001. “A new approach for the synthesis of N,N’- bis(phenoxyacetyl)hydrazines.” İstanbul Journal of Pharmacy 49, no. 2: 61-63. https://doi.org/10.26650/IstanbulJPharm.2019.19002


Chicago: Humanities Style

Apaydın, Çağla Begüm, and Zafer Cesur. “A new approach for the synthesis of N,N’- bis(phenoxyacetyl)hydrazines.” İstanbul Journal of Pharmacy 49, no. 2 (Sep. 2024): 61-63. https://doi.org/10.26650/IstanbulJPharm.2019.19002


Harvard: Australian Style

Apaydın, Ç & Cesur, Z 0001, 'A new approach for the synthesis of N,N’- bis(phenoxyacetyl)hydrazines', İstanbul Journal of Pharmacy, vol. 49, no. 2, pp. 61-63, viewed 27 Sep. 2024, https://doi.org/10.26650/IstanbulJPharm.2019.19002


Harvard: Author-Date Style

Apaydın, Ç. and Cesur, Z. (0001) ‘A new approach for the synthesis of N,N’- bis(phenoxyacetyl)hydrazines’, İstanbul Journal of Pharmacy, 49(2), pp. 61-63. https://doi.org/10.26650/IstanbulJPharm.2019.19002 (27 Sep. 2024).


MLA

Apaydın, Çağla Begüm, and Zafer Cesur. “A new approach for the synthesis of N,N’- bis(phenoxyacetyl)hydrazines.” İstanbul Journal of Pharmacy, vol. 49, no. 2, 0001, pp. 61-63. [Database Container], https://doi.org/10.26650/IstanbulJPharm.2019.19002


Vancouver

Apaydın Ç, Cesur Z. A new approach for the synthesis of N,N’- bis(phenoxyacetyl)hydrazines. İstanbul Journal of Pharmacy [Internet]. 27 Sep. 2024 [cited 27 Sep. 2024];49(2):61-63. Available from: https://doi.org/10.26650/IstanbulJPharm.2019.19002 doi: 10.26650/IstanbulJPharm.2019.19002


ISNAD

Apaydın, Çağla Begüm - Cesur, Zafer. “A new approach for the synthesis of N,N’- bis(phenoxyacetyl)hydrazines”. İstanbul Journal of Pharmacy 49/2 (Sep. 2024): 61-63. https://doi.org/10.26650/IstanbulJPharm.2019.19002



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Accepted02.04.2019

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