Research Article


DOI :10.26650/IstanbulJPharm.2023.1167417   IUP :10.26650/IstanbulJPharm.2023.1167417    Full Text (PDF)

Ameliorative effect of cranberry on erectile function in diabetic rats

Didem Yılmaz OralAlev ÖnderSerap Gür

Background and Aims: Cranberry products are beneficial in erectile dysfunction (ED). Therefore, we assessed the impact of Cranberry fruit extract (Cranberry-E) on in vivo erectile response and in vitro relaxant responses in the corpus cavernosum (CC).

Methods: Rats (n=10) were divided into control and diabetic groups. In vivo erectile function was measured following intracavernosal injection of Cranberry-E. The relaxation responses to Cranberry-E were obtained after pre-contraction with phenylephrine (Phe, 10 𝜇M) and KCl (60 mM). Cranberry-E caused relaxant responses in the incubation with nitric oxide synthase (NOS) blocker (L-NAME, 100 𝜇M) and soluble guanylate cyclase (sGC) blocker (ODQ, 30 𝜇M), and relaxation responses of cavernosal tissue were calculated before and after the incubation with Cranberry-E.

Results: Erectile responseswere significantly reduced in diabetic animals as compared to controls (p<0.001), whichwas normalized after the intracavernous administration of Cranberry-E. There was no difference in the relaxation responses to Cranberry-E between the control and diabetic groups. Cranberry-E induced the relaxation of cavernosal tissue, which remained unaltered in the presence of L-NAME and ODQ. Relaxation responses to Cranberry decreased after KCl-induced precontraction (p<0.001). The relaxation of cavernosal tissue increased after Cranberry-E incubation.

Conclusion: Cranberry-E improved diabetes-induced ED and induced relaxation of cavernosal tissue via a nitric oxide-independent mechanism. Thus, cranberry consumption is likely to be effective as a potential strategy to prevent diabetes-induced ED.


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APA

Yılmaz Oral, D., Önder, A., & Gür, S. (2023). Ameliorative effect of cranberry on erectile function in diabetic rats. İstanbul Journal of Pharmacy, 53(3), 302-307. https://doi.org/10.26650/IstanbulJPharm.2023.1167417


AMA

Yılmaz Oral D, Önder A, Gür S. Ameliorative effect of cranberry on erectile function in diabetic rats. İstanbul Journal of Pharmacy. 2023;53(3):302-307. https://doi.org/10.26650/IstanbulJPharm.2023.1167417


ABNT

Yılmaz Oral, D.; Önder, A.; Gür, S. Ameliorative effect of cranberry on erectile function in diabetic rats. İstanbul Journal of Pharmacy, [Publisher Location], v. 53, n. 3, p. 302-307, 2023.


Chicago: Author-Date Style

Yılmaz Oral, Didem, and Alev Önder and Serap Gür. 2023. “Ameliorative effect of cranberry on erectile function in diabetic rats.” İstanbul Journal of Pharmacy 53, no. 3: 302-307. https://doi.org/10.26650/IstanbulJPharm.2023.1167417


Chicago: Humanities Style

Yılmaz Oral, Didem, and Alev Önder and Serap Gür. Ameliorative effect of cranberry on erectile function in diabetic rats.” İstanbul Journal of Pharmacy 53, no. 3 (Apr. 2024): 302-307. https://doi.org/10.26650/IstanbulJPharm.2023.1167417


Harvard: Australian Style

Yılmaz Oral, D & Önder, A & Gür, S 2023, 'Ameliorative effect of cranberry on erectile function in diabetic rats', İstanbul Journal of Pharmacy, vol. 53, no. 3, pp. 302-307, viewed 28 Apr. 2024, https://doi.org/10.26650/IstanbulJPharm.2023.1167417


Harvard: Author-Date Style

Yılmaz Oral, D. and Önder, A. and Gür, S. (2023) ‘Ameliorative effect of cranberry on erectile function in diabetic rats’, İstanbul Journal of Pharmacy, 53(3), pp. 302-307. https://doi.org/10.26650/IstanbulJPharm.2023.1167417 (28 Apr. 2024).


MLA

Yılmaz Oral, Didem, and Alev Önder and Serap Gür. Ameliorative effect of cranberry on erectile function in diabetic rats.” İstanbul Journal of Pharmacy, vol. 53, no. 3, 2023, pp. 302-307. [Database Container], https://doi.org/10.26650/IstanbulJPharm.2023.1167417


Vancouver

Yılmaz Oral D, Önder A, Gür S. Ameliorative effect of cranberry on erectile function in diabetic rats. İstanbul Journal of Pharmacy [Internet]. 28 Apr. 2024 [cited 28 Apr. 2024];53(3):302-307. Available from: https://doi.org/10.26650/IstanbulJPharm.2023.1167417 doi: 10.26650/IstanbulJPharm.2023.1167417


ISNAD

Yılmaz Oral, Didem - Önder, Alev - Gür, Serap. Ameliorative effect of cranberry on erectile function in diabetic rats”. İstanbul Journal of Pharmacy 53/3 (Apr. 2024): 302-307. https://doi.org/10.26650/IstanbulJPharm.2023.1167417



TIMELINE


Submitted31.08.2022
Accepted21.07.2023
Published Online28.12.2023

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