İstanbul Journal of Pharmacy

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DOI :10.26650/IstanbulJPharm.2022.1001613   IUP :10.26650/IstanbulJPharm.2022.1001613    Full Text (PDF)

Antioxidant and prooxidant properties of selected herbs and Citrus bergamia Risso et Poiteau (bergamot) used for the management of hyperlipidemia

Zehra İlke Akyıldız, Fadime Aydın Köse, Nehir Ünver Somer

Background and Aims: In recent years, there has been an increased interest in the search for herbs to aid the management of hyperlipidemia. There is currently very little data on the simultaneous evaluation of the antioxidant and prooxidant properties of antihyperlipidemic herbs. This study was designed to evaluate the antioxidant and prooxidant properties of four antihyperlipidemic herbal drugs and also of bergamot. Methods: Antioxidant property was determined by ferric ions (Fe3+) reducing capacity (IRC), DPPH radical scavenging activity (DPPH IC50) and trolox equivalent antioxidant capacity (TEAC); deoxyribose degradation test was used for prooxidant property. Results: The highest total phenolic content (TPC) was in the myrtle leaf (ML)(135.35±3.46 mg GAE/g, p<0.05) whereas the highest total flavonoid content (TFC) was in green tea (GT) (48.76±0.69 mg QE/g, p<0.05) both of which were maintained from a pharmacy. Among the bergamot samples, the highest TPC and TFC values were in filtered fruit juice (BFFJ) as 197.35±6.29 mg GAE/100 mL; and 94.14±1.39 mg QE/100 mL; p<0.05, respectively. GT showed the highest antioxidant capacity in IRC and TEAC assays (2.29±0.12 mM TE/g; and 2.32±0.07 mmol TE/mg, p<0.05). The lowest DPPH IC50 was identified in ML from a pharmacy (6.95±0.08 µg/mL; p<0.01). BFFJ had the highest IRC (2.94±0.031 mM TE/10µL), TEAC (5.14±0.084 mmol TE/10 µL) and the lowest DPPH IC50 value (10.561±0.17 µL). GT from a pharmacy and 1mg/mL concentration BFLFJ (filtered and lyophilized) were associated with the lowest hydroxyl radical scavenger activity (0.171±0.013 µM MDA equivalent, p<0.05 and 0.144±0.015 µM MDA equivalent, p<0.05). Conclusion: BFLFJ and GT got the highest attention due to high TPC, TFC, antioxidant and low prooxidant properties. Our results highlight the necessity of clarifying the value of bergamot and GT in this field with further studies.

Keywords: Antioxidant, Bergamot, Citrus bergamia, Medicinal plants, Oxidative stress, Prooxidant

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APA

İlke Akyıldız, Z., Aydın Köse, F., & Ünver Somer, N. (2022). Antioxidant and prooxidant properties of selected herbs and Citrus bergamia Risso et Poiteau (bergamot) used for the management of hyperlipidemia. İstanbul Journal of Pharmacy, 52(2), 156-163. https://doi.org/10.26650/IstanbulJPharm.2022.1001613


AMA

İlke Akyıldız Z, Aydın Köse F, Ünver Somer N. Antioxidant and prooxidant properties of selected herbs and Citrus bergamia Risso et Poiteau (bergamot) used for the management of hyperlipidemia. İstanbul Journal of Pharmacy. 2022;52(2):156-163. https://doi.org/10.26650/IstanbulJPharm.2022.1001613


ABNT

İlke Akyıldız, Z.; Aydın Köse, F.; Ünver Somer, N. Antioxidant and prooxidant properties of selected herbs and Citrus bergamia Risso et Poiteau (bergamot) used for the management of hyperlipidemia. İstanbul Journal of Pharmacy, [Publisher Location], v. 52, n. 2, p. 156-163, 2022.


Chicago: Author-Date Style

İlke Akyıldız, Zehra, and Fadime Aydın Köse and Nehir Ünver Somer. 2022. “Antioxidant and prooxidant properties of selected herbs and Citrus bergamia Risso et Poiteau (bergamot) used for the management of hyperlipidemia.” İstanbul Journal of Pharmacy 52, no. 2: 156-163. https://doi.org/10.26650/IstanbulJPharm.2022.1001613


Chicago: Humanities Style

İlke Akyıldız, Zehra, and Fadime Aydın Köse and Nehir Ünver Somer. “Antioxidant and prooxidant properties of selected herbs and Citrus bergamia Risso et Poiteau (bergamot) used for the management of hyperlipidemia.” İstanbul Journal of Pharmacy 52, no. 2 (May. 2024): 156-163. https://doi.org/10.26650/IstanbulJPharm.2022.1001613


Harvard: Australian Style

İlke Akyıldız, Z & Aydın Köse, F & Ünver Somer, N 2022, 'Antioxidant and prooxidant properties of selected herbs and Citrus bergamia Risso et Poiteau (bergamot) used for the management of hyperlipidemia', İstanbul Journal of Pharmacy, vol. 52, no. 2, pp. 156-163, viewed 18 May. 2024, https://doi.org/10.26650/IstanbulJPharm.2022.1001613


Harvard: Author-Date Style

İlke Akyıldız, Z. and Aydın Köse, F. and Ünver Somer, N. (2022) ‘Antioxidant and prooxidant properties of selected herbs and Citrus bergamia Risso et Poiteau (bergamot) used for the management of hyperlipidemia’, İstanbul Journal of Pharmacy, 52(2), pp. 156-163. https://doi.org/10.26650/IstanbulJPharm.2022.1001613 (18 May. 2024).


MLA

İlke Akyıldız, Zehra, and Fadime Aydın Köse and Nehir Ünver Somer. “Antioxidant and prooxidant properties of selected herbs and Citrus bergamia Risso et Poiteau (bergamot) used for the management of hyperlipidemia.” İstanbul Journal of Pharmacy, vol. 52, no. 2, 2022, pp. 156-163. [Database Container], https://doi.org/10.26650/IstanbulJPharm.2022.1001613


Vancouver

İlke Akyıldız Z, Aydın Köse F, Ünver Somer N. Antioxidant and prooxidant properties of selected herbs and Citrus bergamia Risso et Poiteau (bergamot) used for the management of hyperlipidemia. İstanbul Journal of Pharmacy [Internet]. 18 May. 2024 [cited 18 May. 2024];52(2):156-163. Available from: https://doi.org/10.26650/IstanbulJPharm.2022.1001613 doi: 10.26650/IstanbulJPharm.2022.1001613


ISNAD

İlke Akyıldız, Zehra - Aydın Köse, Fadime - Ünver Somer, Nehir. “Antioxidant and prooxidant properties of selected herbs and Citrus bergamia Risso et Poiteau (bergamot) used for the management of hyperlipidemia”. İstanbul Journal of Pharmacy 52/2 (May. 2024): 156-163. https://doi.org/10.26650/IstanbulJPharm.2022.1001613



TIMELINE


Submitted11.10.2021
Accepted19.05.2022
Published Online29.08.2022

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