İstanbul Journal of Pharmacy

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DOI :10.26650/IstanbulJPharm.2021.892746   IUP :10.26650/IstanbulJPharm.2021.892746    Full Text (PDF)

Bongardia chrysogonum (L.) Spach as a potential medicinal plant against cancer and Alzheimer’s disease management

Sevgi Gezici, Nazım Şekeroğlu

Background and Aims: Bongardia chrysogonum (L.) Spach (Berberidaceae), an ancient medicinal plant in Eastern Mediterranean countries, is traditionally used for the treatment of epilepsy, hemorrhoids, urinary system infections and gastrointestinal disorders. This study was designed to evaluate potential neuroprotective and anticancer effects of different parts from B. chrysogonum. Material and Methods: Leaf, stem, and tuber parts of the plant were extracted and subjected to determine cholinesterase enzyme inhibitory potentials and anticancer activities. Enzyme inhibition assays were carried out to screen neuroprotective potentials, while the MTT assay was performed for evaluating anticancer activities of the extracts towards human lung carcinoma (A549), breast adenocarcinoma (MCF-7), brain glioma (C6), and non-tumorous human umbilical vein endothelial cell (HUVEC) lines. Results: Among the tested extracts, the highest enzyme inhibitory activity was exhibited by tuber-water extract (83.81±0.33% and 62.14±0.60% inhibition on AChE and BChE at 400 µg/mL p<0.01, respectively), whilst the lowest enzyme inhibition was exerted by the tuber-chloroform extract. Moreover, the tuber part of the plant was found to have the most cytotoxic activity against all the cancer cells, and the best anticancer activity was determined in tuber ethanol extract against MCF-7 cells (IC50= 28.36±0.04, p<0.01). Conclusion: To the best of our knowledge, this research is the first study that assessed the in vitro neuroprotective effect of the aerial parts and tuber extracts of the plant through inhibition of cholinesterase enzymes alongside an anticancer capacity towards human cancer cells. The results revealed that this plant is a good candidate for performing further clinical studies in cancer and neurodegenerative diseases.

Keywords: Bongardia chrysogonum (L.) Spach, cancer, enzyme inhibition, medicinal plant, neuroprotection

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Citations

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APA

Gezici, S., & Şekeroğlu, N. (2021). Bongardia chrysogonum (L.) Spach as a potential medicinal plant against cancer and Alzheimer’s disease management. İstanbul Journal of Pharmacy, 51(3), 319-325. https://doi.org/10.26650/IstanbulJPharm.2021.892746


AMA

Gezici S, Şekeroğlu N. Bongardia chrysogonum (L.) Spach as a potential medicinal plant against cancer and Alzheimer’s disease management. İstanbul Journal of Pharmacy. 2021;51(3):319-325. https://doi.org/10.26650/IstanbulJPharm.2021.892746


ABNT

Gezici, S.; Şekeroğlu, N. Bongardia chrysogonum (L.) Spach as a potential medicinal plant against cancer and Alzheimer’s disease management. İstanbul Journal of Pharmacy, [Publisher Location], v. 51, n. 3, p. 319-325, 2021.


Chicago: Author-Date Style

Gezici, Sevgi, and Nazım Şekeroğlu. 2021. “Bongardia chrysogonum (L.) Spach as a potential medicinal plant against cancer and Alzheimer’s disease management.” İstanbul Journal of Pharmacy 51, no. 3: 319-325. https://doi.org/10.26650/IstanbulJPharm.2021.892746


Chicago: Humanities Style

Gezici, Sevgi, and Nazım Şekeroğlu. “Bongardia chrysogonum (L.) Spach as a potential medicinal plant against cancer and Alzheimer’s disease management.” İstanbul Journal of Pharmacy 51, no. 3 (Jul. 2024): 319-325. https://doi.org/10.26650/IstanbulJPharm.2021.892746


Harvard: Australian Style

Gezici, S & Şekeroğlu, N 2021, 'Bongardia chrysogonum (L.) Spach as a potential medicinal plant against cancer and Alzheimer’s disease management', İstanbul Journal of Pharmacy, vol. 51, no. 3, pp. 319-325, viewed 2 Jul. 2024, https://doi.org/10.26650/IstanbulJPharm.2021.892746


Harvard: Author-Date Style

Gezici, S. and Şekeroğlu, N. (2021) ‘Bongardia chrysogonum (L.) Spach as a potential medicinal plant against cancer and Alzheimer’s disease management’, İstanbul Journal of Pharmacy, 51(3), pp. 319-325. https://doi.org/10.26650/IstanbulJPharm.2021.892746 (2 Jul. 2024).


MLA

Gezici, Sevgi, and Nazım Şekeroğlu. “Bongardia chrysogonum (L.) Spach as a potential medicinal plant against cancer and Alzheimer’s disease management.” İstanbul Journal of Pharmacy, vol. 51, no. 3, 2021, pp. 319-325. [Database Container], https://doi.org/10.26650/IstanbulJPharm.2021.892746


Vancouver

Gezici S, Şekeroğlu N. Bongardia chrysogonum (L.) Spach as a potential medicinal plant against cancer and Alzheimer’s disease management. İstanbul Journal of Pharmacy [Internet]. 2 Jul. 2024 [cited 2 Jul. 2024];51(3):319-325. Available from: https://doi.org/10.26650/IstanbulJPharm.2021.892746 doi: 10.26650/IstanbulJPharm.2021.892746


ISNAD

Gezici, Sevgi - Şekeroğlu, Nazım. “Bongardia chrysogonum (L.) Spach as a potential medicinal plant against cancer and Alzheimer’s disease management”. İstanbul Journal of Pharmacy 51/3 (Jul. 2024): 319-325. https://doi.org/10.26650/IstanbulJPharm.2021.892746



TIMELINE


Submitted07.03.2021
Accepted06.10.2021
Published Online30.12.2021

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