Comparative examination of phenolic content, flavonoid content, and  antioxidant efficacy of Chenopodium album L. and Chenopodium pumilio R.  Br.

Kolar Firdose R.; Kambhar Sidanand V.; Kamble Vaishali S.; Daphedar Azharuddin B.

doi:https://dx.doi.org/10.26650/IstanbulJPharm.2024.1313743

Research Article

DOI :10.26650/IstanbulJPharm.2024.1313743 IUP :10.26650/IstanbulJPharm.2024.1313743 Full Text (PDF)

Comparative examination of phenolic content, flavonoid content, and antioxidant efficacy of Chenopodium album L. and Chenopodium pumilio R. Br.

Firdose R. Kolar, Sidanand V. Kambhar, Vaishali S. Kamble, Azharuddin B. Daphedar

Background and Aims: Traditional indigenous system of medicine employed many Chenopodium species to treat a wide range of ailments. Therefore, the current study aims to evaluate the phenolic content, flavonoid content, and antioxidant capacity of the species Chenopodium album and Chenopodium pumilio.

Methods: Phenolics and flavonoid content were quantified using spectrophotometric techniques. The antioxidant activity of Chenopodium extracts was evaluated by assaying ferric reducing antioxidant power, 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity, phosphomolybdenum reducing power, ferrous ion chelating activity, hydrogen peroxide radical scav enging activity, hydroxyl radical scavenging activity, deoxyribose degradation activity, and β-carotene bleaching activity.

Results: In C. album and C. pumilio, total phenolic concentration was 17.5–23.8 and 13.3–25.3 mg tannic acid equivalent/g, respectively, and flavonoid content was 0.21–0.85 mg and 0.10–0.89 mg quercetin equivalent/g, respectively. Thus, C. pumilio had a higher content of phenolics and flavonoids than C. album. However, comparison of extracts in different solvents showed that ethanolic and aqueous extracts exhibited higher phenolics and flavonoid content than other solvent systems. The antioxidant capability of the species, determined by antioxidant assays, varied with the species evaluated and the solvents used for extraction. Remarkably, the correlation coefficient of different antioxidant assays with the phenolics and flavonoid content in both species showed discrepancy.

Conclusion: Ethanolic and aqueous extracts of the Chenopodium species studied had higher phenolics, flavonoids, and free radical scavenging activity than methanolic and acetonic extracts. The ethanolic and aqueous extracts of the studied species provide a potential source of antioxidants for drug formulation.

Keywords: Chenopodium; phenolics; flavonoids; free radicals; reducing power; correlation

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Kolar, F., Kambhar, S., Kamble, V., & Daphedar, A. (2024). Comparative examination of phenolic content, flavonoid content, and antioxidant efficacy of Chenopodium album L. and Chenopodium pumilio R. Br.. İstanbul Journal of Pharmacy, 54(2), 165-174. https://doi.org/10.26650/IstanbulJPharm.2024.1313743

AMA

Kolar F, Kambhar S, Kamble V, Daphedar A. Comparative examination of phenolic content, flavonoid content, and antioxidant efficacy of Chenopodium album L. and Chenopodium pumilio R. Br.. İstanbul Journal of Pharmacy. 2024;54(2):165-174. https://doi.org/10.26650/IstanbulJPharm.2024.1313743

ABNT

Kolar, F.; Kambhar, S.; Kamble, V.; Daphedar, A. Comparative examination of phenolic content, flavonoid content, and antioxidant efficacy of Chenopodium album L. and Chenopodium pumilio R. Br.. İstanbul Journal of Pharmacy, [Publisher Location], v. 54, n. 2, p. 165-174, 2024.

Chicago: Author-Date Style

Kolar, Firdose R., and Sidanand V. Kambhar and Vaishali S. Kamble and Azharuddin B. Daphedar. 2024. “Comparative examination of phenolic content, flavonoid content, and antioxidant efficacy of Chenopodium album L. and Chenopodium pumilio R. Br..” İstanbul Journal of Pharmacy 54, no. 2: 165-174. https://doi.org/10.26650/IstanbulJPharm.2024.1313743

Chicago: Humanities Style

Kolar, Firdose R., and Sidanand V. Kambhar and Vaishali S. Kamble and Azharuddin B. Daphedar. “Comparative examination of phenolic content, flavonoid content, and antioxidant efficacy of Chenopodium album L. and Chenopodium pumilio R. Br..” İstanbul Journal of Pharmacy 54, no. 2 (Nov. 2024): 165-174. https://doi.org/10.26650/IstanbulJPharm.2024.1313743

Harvard: Australian Style

Kolar, F & Kambhar, S & Kamble, V & Daphedar, A 2024, 'Comparative examination of phenolic content, flavonoid content, and antioxidant efficacy of Chenopodium album L. and Chenopodium pumilio R. Br.', İstanbul Journal of Pharmacy, vol. 54, no. 2, pp. 165-174, viewed 15 Nov. 2024, https://doi.org/10.26650/IstanbulJPharm.2024.1313743

Harvard: Author-Date Style

Kolar, F. and Kambhar, S. and Kamble, V. and Daphedar, A. (2024) ‘Comparative examination of phenolic content, flavonoid content, and antioxidant efficacy of Chenopodium album L. and Chenopodium pumilio R. Br.’, İstanbul Journal of Pharmacy, 54(2), pp. 165-174. https://doi.org/10.26650/IstanbulJPharm.2024.1313743 (15 Nov. 2024).

MLA

Kolar, Firdose R., and Sidanand V. Kambhar and Vaishali S. Kamble and Azharuddin B. Daphedar. “Comparative examination of phenolic content, flavonoid content, and antioxidant efficacy of Chenopodium album L. and Chenopodium pumilio R. Br..” İstanbul Journal of Pharmacy, vol. 54, no. 2, 2024, pp. 165-174. [Database Container], https://doi.org/10.26650/IstanbulJPharm.2024.1313743

Vancouver

Kolar F, Kambhar S, Kamble V, Daphedar A. Comparative examination of phenolic content, flavonoid content, and antioxidant efficacy of Chenopodium album L. and Chenopodium pumilio R. Br.. İstanbul Journal of Pharmacy [Internet]. 15 Nov. 2024 [cited 15 Nov. 2024];54(2):165-174. Available from: https://doi.org/10.26650/IstanbulJPharm.2024.1313743 doi: 10.26650/IstanbulJPharm.2024.1313743

ISNAD

Kolar, Firdose R. - Kambhar, Sidanand V. - Kamble, Vaishali S. - Daphedar, Azharuddin B.. “Comparative examination of phenolic content, flavonoid content, and antioxidant efficacy of Chenopodium album L. and Chenopodium pumilio R. Br.”. İstanbul Journal of Pharmacy 54/2 (Nov. 2024): 165-174. https://doi.org/10.26650/IstanbulJPharm.2024.1313743

Volume 54, Issue 22024, P. 165-174

TIMELINE

Submitted	27.06.2023
Accepted	21.03.2024
Published Online	26.08.2024

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