İstanbul Journal of Pharmacy

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DOI :10.26650/IstanbulJPharm.2024.1207607   IUP :10.26650/IstanbulJPharm.2024.1207607    Full Text (PDF)

Comparison of drug–drug interaction checking databases for interactions involving BCR-ABL tyrosine kinase inhibitors

Ayşe Günay, Eren Demirpolat, Mükerrem Betül Yerer Aycan, Ali Ünal

Background and Aims: BCR-ABL tyrosine kinase inhibitors (TKIs) are used for the treatment of chronic myeloid leukemia and are commonly involved in clinically significant drug–drug interactions (DDIs). In this study, we aimed to evaluate the consensus of DDI checking databases for interactions involving BCR-ABL TKIs.

Methods: We checked DDIs of 100 drugs with six BCR-ABL TKIs—dasatinib, imatinib, nilotinib, ponatinib, bosutinib, and asciminib—in two subscription-based databases (UpToDate and Micromedex) and two open-access databases (Drugs.com and Medscape). Databases were compared in terms of severity ratings, literature support ratings, and general interaction mechanism definitions using Fleiss’ and Cohen’s kappa statistics.

Results: A total of 410 interactions were found. Nilotinib was the most interacted TKI, with 88 interactions. Drugs.com detected the highest number of interactions (n = 355). The overall agreement levels of databases for the severity ratings and general mechanisms were calculated as 0.13 (p = 0) and 0.28 (p = 0), respectively. The Micromedex- UpToDate pair showed the highest agreement level in terms of severity ratings and general mechanism definitions, with kappa values of 0.23 and 0.45, respectively.

Conclusion: The differences among databases for DDIs involving BCR-ABL TKIs were statistically significant. Therefore, healthcare practitioners should check DDIs in multiple databases. 

Keywords: Drug-drug interactions, chronic myeloid leukemia, tyrosine kinase inhibitors, TKIs, CML

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APA

Günay, A., Demirpolat, E., Yerer Aycan, M., & Ünal, A. (2024). Comparison of drug–drug interaction checking databases for interactions involving BCR-ABL tyrosine kinase inhibitors. İstanbul Journal of Pharmacy, 54(1), 32-39. https://doi.org/10.26650/IstanbulJPharm.2024.1207607


AMA

Günay A, Demirpolat E, Yerer Aycan M, Ünal A. Comparison of drug–drug interaction checking databases for interactions involving BCR-ABL tyrosine kinase inhibitors. İstanbul Journal of Pharmacy. 2024;54(1):32-39. https://doi.org/10.26650/IstanbulJPharm.2024.1207607


ABNT

Günay, A.; Demirpolat, E.; Yerer Aycan, M.; Ünal, A. Comparison of drug–drug interaction checking databases for interactions involving BCR-ABL tyrosine kinase inhibitors. İstanbul Journal of Pharmacy, [Publisher Location], v. 54, n. 1, p. 32-39, 2024.


Chicago: Author-Date Style

Günay, Ayşe, and Eren Demirpolat and Mükerrem Betül Yerer Aycan and Ali Ünal. 2024. “Comparison of drug–drug interaction checking databases for interactions involving BCR-ABL tyrosine kinase inhibitors.” İstanbul Journal of Pharmacy 54, no. 1: 32-39. https://doi.org/10.26650/IstanbulJPharm.2024.1207607


Chicago: Humanities Style

Günay, Ayşe, and Eren Demirpolat and Mükerrem Betül Yerer Aycan and Ali Ünal. “Comparison of drug–drug interaction checking databases for interactions involving BCR-ABL tyrosine kinase inhibitors.” İstanbul Journal of Pharmacy 54, no. 1 (Nov. 2024): 32-39. https://doi.org/10.26650/IstanbulJPharm.2024.1207607


Harvard: Australian Style

Günay, A & Demirpolat, E & Yerer Aycan, M & Ünal, A 2024, 'Comparison of drug–drug interaction checking databases for interactions involving BCR-ABL tyrosine kinase inhibitors', İstanbul Journal of Pharmacy, vol. 54, no. 1, pp. 32-39, viewed 15 Nov. 2024, https://doi.org/10.26650/IstanbulJPharm.2024.1207607


Harvard: Author-Date Style

Günay, A. and Demirpolat, E. and Yerer Aycan, M. and Ünal, A. (2024) ‘Comparison of drug–drug interaction checking databases for interactions involving BCR-ABL tyrosine kinase inhibitors’, İstanbul Journal of Pharmacy, 54(1), pp. 32-39. https://doi.org/10.26650/IstanbulJPharm.2024.1207607 (15 Nov. 2024).


MLA

Günay, Ayşe, and Eren Demirpolat and Mükerrem Betül Yerer Aycan and Ali Ünal. “Comparison of drug–drug interaction checking databases for interactions involving BCR-ABL tyrosine kinase inhibitors.” İstanbul Journal of Pharmacy, vol. 54, no. 1, 2024, pp. 32-39. [Database Container], https://doi.org/10.26650/IstanbulJPharm.2024.1207607


Vancouver

Günay A, Demirpolat E, Yerer Aycan M, Ünal A. Comparison of drug–drug interaction checking databases for interactions involving BCR-ABL tyrosine kinase inhibitors. İstanbul Journal of Pharmacy [Internet]. 15 Nov. 2024 [cited 15 Nov. 2024];54(1):32-39. Available from: https://doi.org/10.26650/IstanbulJPharm.2024.1207607 doi: 10.26650/IstanbulJPharm.2024.1207607


ISNAD

Günay, Ayşe - Demirpolat, Eren - Yerer Aycan, Mükerrem Betül - Ünal, Ali. “Comparison of drug–drug interaction checking databases for interactions involving BCR-ABL tyrosine kinase inhibitors”. İstanbul Journal of Pharmacy 54/1 (Nov. 2024): 32-39. https://doi.org/10.26650/IstanbulJPharm.2024.1207607



TIMELINE


Submitted21.11.2022
Accepted28.11.2023
Published Online30.04.2024

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