İstanbul Journal of Pharmacy

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Research Article


DOI :10.26650/IstanbulJPharm.2019.19036   IUP :10.26650/IstanbulJPharm.2019.19036    Full Text (PDF)

Development of paclitaxel and flurbiprofen coloaded PLGA nanoparticles: understanding critical formulation and process parameters using Plackett– Burman design

Yılmaz Çapan, Seçil Çaban Toktaş, Adem Şahin, Hayrettin Tonbul, Fırat Yerlikaya, Yeşim Aktaş

Nano drug co-delivery system is a popular strategy for combined application of two or more anticancer and/or synergistic drugs. Synergistic effects of nonsteroidal anti-inflammatory drugs and anti-cancer drugs in cancer treatment are shown in the literature. This study aimed to screen and understand the critical formulation and process parameters in the preparation of flurbiprofen and paclitaxel co-loaded nanoparticles to develop an anti-cancer nano co-delivery system. With this aim, critical parameters were determined using the Plackett–Burman experimental design (DoE). Flurbiprofen and paclitaxel drug loading amounts were considered as critical quality attributes to control the effective drug loading ratio. Furthermore, average particle size and zeta potential were also defined as critical quality attributes in order to optimize passive drug targeting and colloidal stability. Surfactant type was determined as the most significant factor for the average particle size and zeta potential. For flurbiprofen and paclitaxel drug loading into the nanoparticles, amounts of both flurbiprofen and paclitaxel were determined as critical factors. Consequently, paclitaxel and flurbiprofen were efficiently loaded into nanoparticles, and the impact of the formulation variables was successfully screened by a DoE. By controlling the determined parameters, the therapeutic efficacy of co-loaded drug nanoparticles could be maximized in further studies.

Keywords: Nanoparticles, paclitaxel, flurbiprofen, PLGA, design of experiments, Plackett–Burman

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Citations

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APA

Çapan, Y., Çaban Toktaş, S., Şahin, A., Tonbul, H., Yerlikaya, F., & Aktaş, Y. (2019). Development of paclitaxel and flurbiprofen coloaded PLGA nanoparticles: understanding critical formulation and process parameters using Plackett– Burman design. İstanbul Journal of Pharmacy, 49(3), 161-166. https://doi.org/10.26650/IstanbulJPharm.2019.19036


AMA

Çapan Y, Çaban Toktaş S, Şahin A, Tonbul H, Yerlikaya F, Aktaş Y. Development of paclitaxel and flurbiprofen coloaded PLGA nanoparticles: understanding critical formulation and process parameters using Plackett– Burman design. İstanbul Journal of Pharmacy. 2019;49(3):161-166. https://doi.org/10.26650/IstanbulJPharm.2019.19036


ABNT

Çapan, Y.; Çaban Toktaş, S.; Şahin, A.; Tonbul, H.; Yerlikaya, F.; Aktaş, Y. Development of paclitaxel and flurbiprofen coloaded PLGA nanoparticles: understanding critical formulation and process parameters using Plackett– Burman design. İstanbul Journal of Pharmacy, [Publisher Location], v. 49, n. 3, p. 161-166, 2019.


Chicago: Author-Date Style

Çapan, Yılmaz, and Seçil Çaban Toktaş and Adem Şahin and Hayrettin Tonbul and Fırat Yerlikaya and Yeşim Aktaş. 2019. “Development of paclitaxel and flurbiprofen coloaded PLGA nanoparticles: understanding critical formulation and process parameters using Plackett– Burman design.” İstanbul Journal of Pharmacy 49, no. 3: 161-166. https://doi.org/10.26650/IstanbulJPharm.2019.19036


Chicago: Humanities Style

Çapan, Yılmaz, and Seçil Çaban Toktaş and Adem Şahin and Hayrettin Tonbul and Fırat Yerlikaya and Yeşim Aktaş. “Development of paclitaxel and flurbiprofen coloaded PLGA nanoparticles: understanding critical formulation and process parameters using Plackett– Burman design.” İstanbul Journal of Pharmacy 49, no. 3 (May. 2024): 161-166. https://doi.org/10.26650/IstanbulJPharm.2019.19036


Harvard: Australian Style

Çapan, Y & Çaban Toktaş, S & Şahin, A & Tonbul, H & Yerlikaya, F & Aktaş, Y 2019, 'Development of paclitaxel and flurbiprofen coloaded PLGA nanoparticles: understanding critical formulation and process parameters using Plackett– Burman design', İstanbul Journal of Pharmacy, vol. 49, no. 3, pp. 161-166, viewed 9 May. 2024, https://doi.org/10.26650/IstanbulJPharm.2019.19036


Harvard: Author-Date Style

Çapan, Y. and Çaban Toktaş, S. and Şahin, A. and Tonbul, H. and Yerlikaya, F. and Aktaş, Y. (2019) ‘Development of paclitaxel and flurbiprofen coloaded PLGA nanoparticles: understanding critical formulation and process parameters using Plackett– Burman design’, İstanbul Journal of Pharmacy, 49(3), pp. 161-166. https://doi.org/10.26650/IstanbulJPharm.2019.19036 (9 May. 2024).


MLA

Çapan, Yılmaz, and Seçil Çaban Toktaş and Adem Şahin and Hayrettin Tonbul and Fırat Yerlikaya and Yeşim Aktaş. “Development of paclitaxel and flurbiprofen coloaded PLGA nanoparticles: understanding critical formulation and process parameters using Plackett– Burman design.” İstanbul Journal of Pharmacy, vol. 49, no. 3, 2019, pp. 161-166. [Database Container], https://doi.org/10.26650/IstanbulJPharm.2019.19036


Vancouver

Çapan Y, Çaban Toktaş S, Şahin A, Tonbul H, Yerlikaya F, Aktaş Y. Development of paclitaxel and flurbiprofen coloaded PLGA nanoparticles: understanding critical formulation and process parameters using Plackett– Burman design. İstanbul Journal of Pharmacy [Internet]. 9 May. 2024 [cited 9 May. 2024];49(3):161-166. Available from: https://doi.org/10.26650/IstanbulJPharm.2019.19036 doi: 10.26650/IstanbulJPharm.2019.19036


ISNAD

Çapan, Yılmaz - Çaban Toktaş, Seçil - Şahin, Adem - Tonbul, Hayrettin - Yerlikaya, Fırat - Aktaş, Yeşim. “Development of paclitaxel and flurbiprofen coloaded PLGA nanoparticles: understanding critical formulation and process parameters using Plackett– Burman design”. İstanbul Journal of Pharmacy 49/3 (May. 2024): 161-166. https://doi.org/10.26650/IstanbulJPharm.2019.19036



TIMELINE


Accepted10.09.2019

LICENCE


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