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DOI :10.26650/IstanbulJPharm.2024.1330470   IUP :10.26650/IstanbulJPharm.2024.1330470    Full Text (PDF)

Drug-drug interactions with venetoclax in acute myeloid leukemia

Şaziye Esra Tubay, Serhat Çelik, Ali Ünal

Background and Aims: Venetoclax is an important treatment option, especially in patients who are unfit for acute myeloid leukemia treatment. However, because venetoclax is metabolized by CYP3A4, it can lead to many drug-drug interactions (DDIs). DDIs may make a drug less effective, cause unexpected side effects, or increase the action of a particular drug. This study aims to examine venetoclax-related DDIs in this vulnerable patient population and to illuminate possible interventions for both patients and clinicians.

Methods: This observational study was performed between November 2018-December 2022 in the Department of Hematology, Erciyes University Faculty of Medicine. The study involves 60 patients and uses Lexi-interact® to determine potential DDIs (pDDIs) in all patients and uses Lexi-interact® to take into account category D and category X interactions.

Results: Forty-seven (78.4%) patients experienced drug interactions. The most common drug interactions were with azole antifungals, most commonly with posaconazole in category D (31.6%). Clarithromycin and diltiazem were found in more than 20% of patients. Carbamazepine, phenytoin and cladribine were found as contraindicated (category X) drugs.

Conclusion: The study shows that at least 78.4% of the patients treated with venetoclax were at risk of DDIs. Dose reduction of venetoclax is necessary when used with azole antifungals. Due to the extremely high occurrence of DDIs, pharmacists have a significant role in drug interaction management in the multidisciplinary team.

Keywords: Acute myeloid leukemia, Interaction, Posaconazole, Venetoclax

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APA

Tubay, Ş.E., Çelik, S., & Ünal, A. (2024). Drug-drug interactions with venetoclax in acute myeloid leukemia. İstanbul Journal of Pharmacy, 54(3), 345-349. https://doi.org/10.26650/IstanbulJPharm.2024.1330470


AMA

Tubay Ş E, Çelik S, Ünal A. Drug-drug interactions with venetoclax in acute myeloid leukemia. İstanbul Journal of Pharmacy. 2024;54(3):345-349. https://doi.org/10.26650/IstanbulJPharm.2024.1330470


ABNT

Tubay, Ş.E.; Çelik, S.; Ünal, A. Drug-drug interactions with venetoclax in acute myeloid leukemia. İstanbul Journal of Pharmacy, [Publisher Location], v. 54, n. 3, p. 345-349, 2024.


Chicago: Author-Date Style

Tubay, Şaziye Esra, and Serhat Çelik and Ali Ünal. 2024. “Drug-drug interactions with venetoclax in acute myeloid leukemia.” İstanbul Journal of Pharmacy 54, no. 3: 345-349. https://doi.org/10.26650/IstanbulJPharm.2024.1330470


Chicago: Humanities Style

Tubay, Şaziye Esra, and Serhat Çelik and Ali Ünal. “Drug-drug interactions with venetoclax in acute myeloid leukemia.” İstanbul Journal of Pharmacy 54, no. 3 (Mar. 2025): 345-349. https://doi.org/10.26650/IstanbulJPharm.2024.1330470


Harvard: Australian Style

Tubay, ŞE & Çelik, S & Ünal, A 2024, 'Drug-drug interactions with venetoclax in acute myeloid leukemia', İstanbul Journal of Pharmacy, vol. 54, no. 3, pp. 345-349, viewed 14 Mar. 2025, https://doi.org/10.26650/IstanbulJPharm.2024.1330470


Harvard: Author-Date Style

Tubay, Ş.E. and Çelik, S. and Ünal, A. (2024) ‘Drug-drug interactions with venetoclax in acute myeloid leukemia’, İstanbul Journal of Pharmacy, 54(3), pp. 345-349. https://doi.org/10.26650/IstanbulJPharm.2024.1330470 (14 Mar. 2025).


MLA

Tubay, Şaziye Esra, and Serhat Çelik and Ali Ünal. “Drug-drug interactions with venetoclax in acute myeloid leukemia.” İstanbul Journal of Pharmacy, vol. 54, no. 3, 2024, pp. 345-349. [Database Container], https://doi.org/10.26650/IstanbulJPharm.2024.1330470


Vancouver

Tubay ŞE, Çelik S, Ünal A. Drug-drug interactions with venetoclax in acute myeloid leukemia. İstanbul Journal of Pharmacy [Internet]. 14 Mar. 2025 [cited 14 Mar. 2025];54(3):345-349. Available from: https://doi.org/10.26650/IstanbulJPharm.2024.1330470 doi: 10.26650/IstanbulJPharm.2024.1330470


ISNAD

Tubay, ŞaziyeEsra - Çelik, Serhat - Ünal, Ali. “Drug-drug interactions with venetoclax in acute myeloid leukemia”. İstanbul Journal of Pharmacy 54/3 (Mar. 2025): 345-349. https://doi.org/10.26650/IstanbulJPharm.2024.1330470



TIMELINE


Submitted24.07.2023
Accepted08.12.2023
Published Online30.12.2024

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