Original Research


DOI :10.26650/IstanbulJPharm.2019.0012   IUP :10.26650/IstanbulJPharm.2019.0012    Full Text (PDF)

Effects of Duraseal® and Fibrin Glue on healing of normal and ischemic colon anastomosis

Halil KaraKenan Ulualp

Background and Aims: Anastomotic leaks represent a major complication of colorectal surgery. This study, involving a rat model of normal and ischemic colon anastomosis, aims to compare the effects of Duraseal® with those of Fibrin Glue (FG).

Methods: Fifty adult male Wistar Albino rats were divided into six groups; normal colon anastomosis, ischemic colon anastomosis, FG on normal colon anastomosis, Duraseal® on normal colon anastomosis, FG on ischemic colon anastomosis, Duraseal® on ischemic colon anastomosis. After scarification, bursting pressure were measured and samples were collected for histopathological examination and hydroxyproline assays.

Results: While the mean bursting pressure was statistically higher in groups treated with Duraseal® when compared to controls (p<0.05), no significant differences between Duraseal® and FG were detected (p>0.05). The mean hydroxyproline level was significantly lower in the Duraseal® groups than in the FG groups (p<0.05). However, significant differences between Duraseal® and control groups were found only in ischemic colon anastomosis (p<0.05). Histopathological examinations did not show any differences in wound healing.

Conclusion: Considering the advantages associated with the use of Duraseal®, we may assume that it may play role in gastrointestinal surgery with respect to prevention of anastomotic leaks. However, data is limited, and further studies are warranted to better define its place in surgery.


PDF View

References

  • Aghayeva, A., Benlice, C., Bilgin, I. A., Atukeren, P., Dogusoy, G., Demir, F., Baca, B. (2017). The effects of hyperthermic intraperitoneal chemoperfusion on colonic anastomosis: an experimental study in a rat model. Tumori Journal, 103(3), 307–313. google scholar
  • Daglioglu, Y. K., Duzgun, O., Sarici, I. S., & Ulutas, K. T. (2018). Comparison of platelet rich plasma versus fibrin glue on colonic anastomoses in rats. Acta Cirurgica Brasileira, 33(4), 333–340. google scholar
  • Demiryas, S., Hatipoğlu, E., Orhan, A., Demiryas, S., Süzer, Ö., Bülbül Doğusoy, G., İpek, T. (2019). Effects of Calcium Dobesilate on Colonic Anastomosis Healing: An Experimental Study. Turkish Journal of Colorectal Disease, 29, 146–152. google scholar
  • Ersoy, O. F., Ozkan, N., Ozsoy, Z., Kayaoglu, H. A., Yenidogan, E., Celik, A., Lortlar, N. (2016). Effects of melatonin on cytokine release and healing of colonic anastomoses in an experimental sepsis model. Ulusal Travma ve Acil Cerrahi Dergisi, 22(4), 315–321. google scholar
  • Fullum, T. M., Aluka, K. J., & Turner, P. L. (2009). Decreasing anastomotic and staple line leaks after laparoscopic Roux-en-Y gastric bypass. Surgical Endoscopy, 23(6), 1403–1408. google scholar
  • Jeon, S. H., Lee, S. H., Tsang, Y. S., Jung, T. G., Moon, K. H., Choi, G., & Dilip, K. D. (2017). Watertight Sealing Without Lumbar Drainage for Incidental Ventral Dural Defect in Transthoracic Spine Surgery: A Retrospective Review of 53 Cases. Clinical Spine Surgery, 30(6), E702–E706. google scholar
  • Karagoz Avci, S., Yuceyar, S., Aytac, E., Bayraktar, O., Erenler, I., Ustun, H., Erturk, S. (2011). Comparison of classical surgery and sutureless repair with DuraSeal or fibrin glue for duodenal perforation in rats. Ulusal Travma ve Acil Cerrahi Dergisi, 17(1), 9–13. google scholar
  • Lee, H. S., Shun, C. T., Chiou, L. L., Chen, C. H., Huang, G. T., & Sheu, J. C. (2005). Hydroxyproline content of needle biopsies as an objective measure of liver fibrosis: Emphasis on sampling variability. Journal of Gastroenteroolgy and Hepatology, 20(7), 1109–1114. google scholar
  • McArdle, C. S., McMillan, D. C., & Hole, D. J. (2005). Impact of anastomotic leakage on long-term survival of patients undergoing curative resection for colorectal cancer. British Journal of Surgery, 92(9), 1150–1154. google scholar
  • Nishimura, K., Kimura, T., & Morita, A. (2012). Watertight dural closure constructed with DuraSeal TM for bypass surgery. Neurologia Medico-Chirurgica (Tokyo), 52(7), 521–524. google scholar
  • Osbun, J. W., Ellenbogen, R. G., Chesnut, R. M., Chin, L. S., Connolly, P. J., Cosgrove, G. R., Wilberger, J. E. (2012). A multicenter, singleblind, prospective randomized trial to evaluate the safety of a polyethylene glycol hydrogel (Duraseal Dural Sealant System) as a dural sealant in cranial surgery. World Neurosurgery, 78(5), 498–504. google scholar
  • Pereira, E. A. C., Grandidge, C. A., Nowak, V. A., & Cudlip, S. A. (2017). Cerebrospinal fluid leaks after transsphenoidal surgery - Effect of a polyethylene glycol hydrogel dural sealant. Journal of Clinical Neuroscience, 44, 6–10. google scholar
  • Piso, P., Nedelcut, S. D., Rau, B., Konigsrainer, A., Glockzin, G., Strohlein, M. A., Pelz, J. (2019). Morbidity and Mortality Following Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: Data from the DGAV StuDoQ Registry with 2149 Consecutive Patients. Annals of Surgical Oncology, 26(1), 148–154. google scholar
  • Portilla-de Buen, E., Orozco-Mosqueda, A., Leal-Cortes, C., Vazquez-Camacho, G., Fuentes-Orozco, C., Alvarez-Villasenor, A. S., Gonzalez-Ojeda, A. (2014). Fibrinogen and thrombin concentrations are critical for fibrin glue adherence in rat high-risk colon anastomoses. Clinics (Sao Paulo), 69(4), 259–264. google scholar
  • Preul, M. C., Bichard, W. D., & Spetzler, R. F. (2003). Toward optimal tissue sealants for neurosurgery: use of a novel hydrogel sealant in a canine durotomy repair model. Neurosurgery, 53(5), 1189- 1198. google scholar
  • Raptis, D., Pramateftakis, M. G., & Kanellos, I. (2018). Our 20-year experience with experimental colonic anastomotic healing. Journal of Medicine and Life, 11(1), 5–14. google scholar
  • Senol, M., Altintas, M. M., Cevik, A., Altuntas, Y. E., Barisik, N. O., Bildik, N., & Oncel, M. (2013). The effect of fibrin glue on the intensity of colonic anastomosis in the presence and absence of peritonitis: an experimental randomized controlled trial on rats. ISRN Surgery, 2013, 521413. google scholar
  • Strong, M. J., West, G. A., Woo, H., Couture, D. E., Wilson, J. A., Munoz, L. F., Asher, A. L. (2017). A Pivotal Randomized Clinical Trial Evaluating the Safety and Effectiveness of a Novel Hydrogel Dural Sealant as an Adjunct to Dural Repair. Operative Neurosurgery (Hagerstown), 13(2), 204–212. google scholar
  • Torres-Melero, J., Motos-Mico, J. J., Lorenzo-Linan, M., Morales- Gonzalez, A., & Rosado-Cobian, R. (2016). Use of absorbable fibrin sealant patch to strengthen the gastrointestinal anastomosis performed on patients with peritoneal carcinomatosis treated with intention to cure by debulking surgery and intraoperative hyperthermic intraperitoneal chemotherapy. Cirrugia Cirujanos, 84(2), 102–108. google scholar
  • Vakalopoulos, K. A., Wu, Z., Kroese, L. F., Jeekel, J., Kleinrensink, G. J., Dodou, D., Lange, J. F. (2017a). Sutureless closure of colonic defects with tissue adhesives: an in vivo study in the rat. American Journal of Surgery, 213(1), 151–158. google scholar
  • Vakalopoulos, K. A., Wu, Z., Kroese, L. F., van der Horst, P. H., Lam, K. H., Dodou, D., Lange, J. F. (2017b). Clinical, mechanical, and immunohistopathological effects of tissue adhesives on the colon: An in-vivo study. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 105(4), 846–854. google scholar
  • Wu, Z., Boersema, G. S., Kroese, L. F., Taha, D., Vennix, S., Bastiaansen- Jenniskens, Y. M., Lange, J. F. (2015). Reducing colorectal anastomotic leakage with tissue adhesive in experimental inflammatory bowel disease. Inflammatory Bowel Diseases, 21(5), 1038–1046. google scholar
  • Zoegall, S. G. (2008). New clinical perspectives from nurses on aprotinin and fibrin sealants. Journal Vascular Nursing, 26(4), 100. google scholar

Citations

Copy and paste a formatted citation or use one of the options to export in your chosen format


EXPORT



APA

Kara, H., & Ulualp, K. (2020). Effects of Duraseal® and Fibrin Glue on healing of normal and ischemic colon anastomosis. İstanbul Journal of Pharmacy, 50(2), 83-88. https://doi.org/10.26650/IstanbulJPharm.2019.0012


AMA

Kara H, Ulualp K. Effects of Duraseal® and Fibrin Glue on healing of normal and ischemic colon anastomosis. İstanbul Journal of Pharmacy. 2020;50(2):83-88. https://doi.org/10.26650/IstanbulJPharm.2019.0012


ABNT

Kara, H.; Ulualp, K. Effects of Duraseal® and Fibrin Glue on healing of normal and ischemic colon anastomosis. İstanbul Journal of Pharmacy, [Publisher Location], v. 50, n. 2, p. 83-88, 2020.


Chicago: Author-Date Style

Kara, Halil, and Kenan Ulualp. 2020. “Effects of Duraseal® and Fibrin Glue on healing of normal and ischemic colon anastomosis.” İstanbul Journal of Pharmacy 50, no. 2: 83-88. https://doi.org/10.26650/IstanbulJPharm.2019.0012


Chicago: Humanities Style

Kara, Halil, and Kenan Ulualp. Effects of Duraseal® and Fibrin Glue on healing of normal and ischemic colon anastomosis.” İstanbul Journal of Pharmacy 50, no. 2 (May. 2024): 83-88. https://doi.org/10.26650/IstanbulJPharm.2019.0012


Harvard: Australian Style

Kara, H & Ulualp, K 2020, 'Effects of Duraseal® and Fibrin Glue on healing of normal and ischemic colon anastomosis', İstanbul Journal of Pharmacy, vol. 50, no. 2, pp. 83-88, viewed 20 May. 2024, https://doi.org/10.26650/IstanbulJPharm.2019.0012


Harvard: Author-Date Style

Kara, H. and Ulualp, K. (2020) ‘Effects of Duraseal® and Fibrin Glue on healing of normal and ischemic colon anastomosis’, İstanbul Journal of Pharmacy, 50(2), pp. 83-88. https://doi.org/10.26650/IstanbulJPharm.2019.0012 (20 May. 2024).


MLA

Kara, Halil, and Kenan Ulualp. Effects of Duraseal® and Fibrin Glue on healing of normal and ischemic colon anastomosis.” İstanbul Journal of Pharmacy, vol. 50, no. 2, 2020, pp. 83-88. [Database Container], https://doi.org/10.26650/IstanbulJPharm.2019.0012


Vancouver

Kara H, Ulualp K. Effects of Duraseal® and Fibrin Glue on healing of normal and ischemic colon anastomosis. İstanbul Journal of Pharmacy [Internet]. 20 May. 2024 [cited 20 May. 2024];50(2):83-88. Available from: https://doi.org/10.26650/IstanbulJPharm.2019.0012 doi: 10.26650/IstanbulJPharm.2019.0012


ISNAD

Kara, Halil - Ulualp, Kenan. Effects of Duraseal® and Fibrin Glue on healing of normal and ischemic colon anastomosis”. İstanbul Journal of Pharmacy 50/2 (May. 2024): 83-88. https://doi.org/10.26650/IstanbulJPharm.2019.0012



TIMELINE


Submitted14.02.2020
Accepted29.04.2020
Published Online27.08.2020

LICENCE


Attribution-NonCommercial (CC BY-NC)

This license lets others remix, tweak, and build upon your work non-commercially, and although their new works must also acknowledge you and be non-commercial, they don’t have to license their derivative works on the same terms.


SHARE




Istanbul University Press aims to contribute to the dissemination of ever growing scientific knowledge through publication of high quality scientific journals and books in accordance with the international publishing standards and ethics. Istanbul University Press follows an open access, non-commercial, scholarly publishing.