Research Article


DOI :10.26650/IstanbulJPharm.2019.18001   IUP :10.26650/IstanbulJPharm.2019.18001    Full Text (PDF)

Evaluation of biological activity of Diplotaenia cachrydifolia Boiss. that medicinal plant

Serpil UğraşSultan ÜlgerPınar Göç Rasgele

The aim of this study is to evaluate the antimicrobial, antioxidant, and antigenotoxic activity of extracts obtained from Diplotaenia cachrydifolia Boiss, which is traditionally used for food and medical treatment by the local people of Hakkâri Province (Turkey). As a result of this study, the extracts of D. cachrydifolia exhibited a broad antimicrobial spectrum and high antimicrobial activity. It was also observed that the extracts had a high antioxidant activity. The DPPH IC50 values of the extracts were 2.5234 µg/mL, 6.0075 µg/mL, and 29.1974 µg/mL for ethanol, acetone, and hexane, respectively. The highest phenol content was found to be 55.36±0.035 µg/mL for ethanol. Furthermore, the ethanol extract was found to have a protective effect against mitomycin C-induced genotoxicity. D. cachrydifolia has a high biological activity; therefore, it is anticipated that future pharmacological studies will shed more light on this plant. 


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References

  • Agaoglu S, Dostbil N, Alemdar S (2005). The Antibacterial Efficiency Of Some Herbs Used in Herby Cheese. YYÜ Vet Fak Derg 2: 39-41. google scholar
  • Amkiss S, Dallouh A, Idaomar M, Amkiss B (2013). Genotoxicity and anti-genotoxicity of fennel plant (Foeniculum vulgare Mill) fruit extracts using the somatic mutation and recombination test (SMART). Afr J Food Sci 7: 193-197. google scholar
  • Anokwuru CP, Anyasor GN, Ajibaye O, Fakoya O, Okebugwu P (2011). Effect of extraction solvents on phenolic, flavonoid and antioxidant activities of three Nigerian medicinal plants. Nature and Science 9: 53-61. google scholar
  • Arullappan S, Zakaria Z, Basri DF (2009). Preliminary Screening of Antibacterial Activity Using Crude Extracts of Hibiscus Rosa sinensis. Trop Life Sci Res 20: 109-118. google scholar
  • Atoui K, Mansouri A, Boskou G, Kefalas P (2005). Tea and Herbal infusions: Their antioksidant activity and phenolic profile. Food Chem 89: 27-36. google scholar
  • Azarnivand H, Alikhah Asl M, Arzani H, Amin Gh, Jafari M, Mousavi SS (2009). The variations of oil content and composition of Diplotaenia cachrydifolia Boiss. in green and dry states as a forage anti-quality factor. Iranian Journal of Medicinal and Aromatic Plants 25: 85-91. google scholar
  • Baravalia Y, Kaneria M, Vaghaslya Y, Parekh J, Chanda S (2009). Antioxidant and antibacterial activity of Diospyros ebenum roxb. leaf extracts. Turk J Biol 33: 159-164. google scholar
  • Berber I, Avsar C, Cin N, Bozkurt N, Elmas E (2013). Determination of Antibacterial and Antifungal Activities of Methanolic Extracts of Some Plants Growing in Sinop. Karaelmas Sci Eng J 3: 10-16. google scholar
  • Bhouri W, Derbel S, Skandrani I, Boubaker J, Bouhlel IB, Sghaier M, Kilani SM, Mariotte A, Dijoux-Franca MG, Ghedira K, Chekir-Ghedira L (2010) Study of genotoxic, antigenotoxic and antioxidant activities of the digallic acid isolated from Pistacia lentiscus fruits. Toxicol In Vitro 24: 509-515. google scholar
  • Brand Williams W, Cuvelier ME, Berset C (1995) Use of a free radical method to evaluate antioxidant activity. Lebensm Wiss Technol 28: 25-30. google scholar
  • Cavlak S, Yagmur C (2016). Determination of Total Phenolic Content and Antioxidant Activities Some Of Tea Bags. CU J Sci Engineering 34: 11-19. google scholar
  • Chaabane F, Boubaker J, Loussaif A, Neffati A, Kilani-Jaziri S, Ghedira K, Chekir-Ghedira L (2012). Antioxidant, genotoxic and antigenotoxic activities of Daphne gnidium leaf extracts. BMC Complement Altern Med 12: 153. google scholar
  • Christova-Bagdassarian VL, Bagdassarian KS, Atanassova MS, Ahmad MA (2014). Comparative Analysis of Total Phenolic and Total Flavonoid Contents, Rutin, Tannins and Antioxidant Capacity in Apiaceae and Lamiaceae families. Indian Horticulture Journal 4: 131-140. google scholar
  • Christova-Bagdassarian VL, Bagdassarian KS, Atanassova MS (2013). Phenolic profile, antioxidant and antimicrobial activities from the Apiaceae family (dry seeds). MJPMS 2: 26-31. google scholar
  • Chung KT, Thomasson WR, Wu-Yuan CD (1990). Growth inhibition of selected food-borne bacteria, particularly Listeria monocytogenes, by plant extracts. J Appl Bacteriol 69: 498-503. google scholar
  • Coruh N, Sagdıcoglu Celep AG, Ozgokce F (2007). Antioxidant properties of Prangos ferulacea (L.) Lindl., Chaerophyllum macropodum Boiss. and Heracleum persicum Desf. from Apiaceae family used as food in Eastern Anatolia and their inhibitory effects on glutathione-S-transferase. Food Chem 100: 1237-1242. google scholar
  • Darlington CA, La Cour LE (1979). The Handling of Chromosomes. 6th ed. Allen and Unwin, London, p.201. google scholar
  • Demir E, Kaya B, Marcos R, Kocaoğlu Cenkci S, Çetin H (2013). Investigation of the genotoxic and antigenotoxic properties of essential oils obtained from two Origanum species by Drosophila wing SMART assay. Turk J Biol 37: 129-138. google scholar
  • Döger MM (2010). Antioxidant activity of Trachystemon orientalis (L.) G. Don. Institute of Science, Department of Chemistry, PhD. Thesis, İstanbul University. google scholar
  • Eftekhar F, Yousefzadi M, Azizian D, Sonboli A, Salehi P (2005). Essential oil composition and antimicrobial activity of Diplotaenia damavandica. Z Naturforsch C 60: 821-825. google scholar
  • Ertürk O, Şahin H, Kolaylı S, Çol Ayvaz M (2014). Antioxidant and antimicrobial activity of East Black Sea Region honeys. Turk J Biochem 39: 99-106. google scholar
  • Harkiss KJ, Salehy Surmaghy MH (1988). Diplotaenia cachrydifolia, a new source of jatamansin and jatamansinol. Fitoterapia 59: 55-56. google scholar
  • Kada T, Morita K, Inoue T (1978). Antimutagenic action of vegetable factor (s) on the mutagenic principle of tryptophan pyrolysate. Mutat Res 53: 351-353. google scholar
  • Karamova NS, Fatykhova DG, Abdrakhimova YR, Il’inskaya ON (2011). An Investigation of Antigenotoxic Properties of Plant Extracts of Chelidonium majus L., Plantago major L. and Tussilago farfara L. Russ J Genet 1: 371-378. google scholar
  • Kaval I, Behçet L, Cakilcioglu U (2014). Ethnobotanical study on medicinal plants in Geçitli and its surrounding (Hakkari-Turkey). J Ethnopharmacol 155: 171-184. google scholar
  • Khajeh M, Moghaddam MG, Shakeri M (2012). Application of artificial neural network in predicting the extraction yield of essential oils of Diplotaenia cachrydifolia by supercritical fluid extraction. J Supercritical Fluids 69: 91-96. google scholar
  • Kilani-Jaziri S, Bhouri W, Skandrani I, Limem I, Chekir-Ghedira L, Ghedira K (2011). Phytochemical, antimicrobial, antioxidant and antigenotoxic potentials of Cyperus rotundus extracts. S Afr J Bot 77: 767-776. google scholar
  • Kumari A, Sharma S, Vig AP (2013). Evaluation of anticytogenetic effects of Brassica oleraceae L. Var. Italica in Allium cepa. Int J Pharm Pharm Sci 5: 120-124. google scholar
  • Lima DC dS, Vale C Rd, Ve´ras JH, Bernardes A, Pe´rez CN, Chen-Chen L (2017). Absence of genotoxic effects of the chalcone (E)-1-(2-hydroxyphenyl)-3-(4-methylphenyl)-prop-2-en-1-one) and its potential chemoprevention against DNA damage using in vitro and in vivo assays. Plos One 12: 1-15. google scholar
  • Mükemre M, Behçet L, Çakılcıoğlu U (2015). Ethnobotanical study on medicinal plants in villages of Çatak (Van-Turkey). J Ethnopharmacol 166: 361-374. google scholar
  • Nogochi C, Nikki E (2000). Phenolic antioxidants: A rationale for design and evaluation of novel antioxidant drugs for atherosclerosis. Free Radic Biol Med 28: 1538-1546. google scholar
  • Rasool Hassan BA (2012). Medicinal Plants (Importance and Uses). Pharm Anal Acta 3: 139. google scholar
  • Rates SMK (2001). Plants as source of drugs. Toxicon 39: 603-613. google scholar
  • Sen A, Batra A (2012). Evaluation of antimicrobial activity of different solvent extracts of medicinal plant: Melia Azedarach L. Int J Curr Pharm Res 4: 67–73. google scholar
  • Silva DSBS, Barboza B, Garcia ACFS, Oliveira B de Estevam CS, Neto VA, et al. (2013). Investigation of protective effects of Erythrina velutina extract against MMS induced damages in the root meristem cells of Allium cepa. Rev Bras Farmacogn 23: 273-278. google scholar
  • Sokmen BB, Ugras S, Sarikaya HY, Ugras HI, Yanardag R (2013). Antibacterial, antiurease and antioxidant activities of some Arylidene barbiturates. Appl Biochem Biotechnol 171: 2030-2039. google scholar
  • Uce I, Tunçtürk M (2014). Wild Plants which Naturally Grown and Widely Used in Hakkari. Res J Biol Sci 7: 21-25. google scholar
  • Young IS, Woodside JV (2001). Antioxidants in health and disease. J Clin Pathol 54: 176-186. google scholar

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APA

Uğraş, S., Ülger, S., & Göç Rasgele, P. (0001). Evaluation of biological activity of Diplotaenia cachrydifolia Boiss. that medicinal plant. İstanbul Journal of Pharmacy, 49(2), 45-52. https://doi.org/10.26650/IstanbulJPharm.2019.18001


AMA

Uğraş S, Ülger S, Göç Rasgele P. Evaluation of biological activity of Diplotaenia cachrydifolia Boiss. that medicinal plant. İstanbul Journal of Pharmacy. 0001;49(2):45-52. https://doi.org/10.26650/IstanbulJPharm.2019.18001


ABNT

Uğraş, S.; Ülger, S.; Göç Rasgele, P. Evaluation of biological activity of Diplotaenia cachrydifolia Boiss. that medicinal plant. İstanbul Journal of Pharmacy, [Publisher Location], v. 49, n. 2, p. 45-52, 0001.


Chicago: Author-Date Style

Uğraş, Serpil, and Sultan Ülger and Pınar Göç Rasgele. 0001. “Evaluation of biological activity of Diplotaenia cachrydifolia Boiss. that medicinal plant.” İstanbul Journal of Pharmacy 49, no. 2: 45-52. https://doi.org/10.26650/IstanbulJPharm.2019.18001


Chicago: Humanities Style

Uğraş, Serpil, and Sultan Ülger and Pınar Göç Rasgele. Evaluation of biological activity of Diplotaenia cachrydifolia Boiss. that medicinal plant.” İstanbul Journal of Pharmacy 49, no. 2 (Sep. 2024): 45-52. https://doi.org/10.26650/IstanbulJPharm.2019.18001


Harvard: Australian Style

Uğraş, S & Ülger, S & Göç Rasgele, P 0001, 'Evaluation of biological activity of Diplotaenia cachrydifolia Boiss. that medicinal plant', İstanbul Journal of Pharmacy, vol. 49, no. 2, pp. 45-52, viewed 27 Sep. 2024, https://doi.org/10.26650/IstanbulJPharm.2019.18001


Harvard: Author-Date Style

Uğraş, S. and Ülger, S. and Göç Rasgele, P. (0001) ‘Evaluation of biological activity of Diplotaenia cachrydifolia Boiss. that medicinal plant’, İstanbul Journal of Pharmacy, 49(2), pp. 45-52. https://doi.org/10.26650/IstanbulJPharm.2019.18001 (27 Sep. 2024).


MLA

Uğraş, Serpil, and Sultan Ülger and Pınar Göç Rasgele. Evaluation of biological activity of Diplotaenia cachrydifolia Boiss. that medicinal plant.” İstanbul Journal of Pharmacy, vol. 49, no. 2, 0001, pp. 45-52. [Database Container], https://doi.org/10.26650/IstanbulJPharm.2019.18001


Vancouver

Uğraş S, Ülger S, Göç Rasgele P. Evaluation of biological activity of Diplotaenia cachrydifolia Boiss. that medicinal plant. İstanbul Journal of Pharmacy [Internet]. 27 Sep. 2024 [cited 27 Sep. 2024];49(2):45-52. Available from: https://doi.org/10.26650/IstanbulJPharm.2019.18001 doi: 10.26650/IstanbulJPharm.2019.18001


ISNAD

Uğraş, Serpil - Ülger, Sultan - Göç Rasgele, Pınar. Evaluation of biological activity of Diplotaenia cachrydifolia Boiss. that medicinal plant”. İstanbul Journal of Pharmacy 49/2 (Sep. 2024): 45-52. https://doi.org/10.26650/IstanbulJPharm.2019.18001



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Accepted31.05.2019

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