Research Article


DOI :10.26650/IstanbulJPharm.2024.1269717   IUP :10.26650/IstanbulJPharm.2024.1269717    Full Text (PDF)

Flurbiprofen-encapsulated microsphere laden into heat-triggered situ gel for ocular delivery

Heybet Kerem PolatSedat Ünal

Background and Aims: This investigation aimed to enhance flurbiprofen’s (FB) pre-corneal residence period and ocular availability in the postoperative management of ocular inflammation.

Methods: The microsphere (MS) material was poly (lactic-co-glycolic acid) PLGA, and FB-laden microspheres were prepared using a single emulsification/solvent evaporation process, loaded onto thermosensitive in situ gels, and then characterised.

Results: The size of the microparticles was measured as 19.3±2.1 μm. Entrapment efficiency, zeta potential, and in vitro release; it was observed that the microspheres were released for six days. The optimum gelling capacity was obtained using 15% Poloxamer 407, 8% Poloxamer 188, and 1% HEC (viscosity 80-125 cp). Poloxamer 407 concentration was reduced, resulting in increased gelation temperature and duration. It was determined that the gelling temperature of the selected formulation was 35±0.1 °C, the pH was 6.9±0.02, and the viscosity at the gelling temperature was 11042±247 cP. The addition of hydroxyethyl cellulose increased the mucoadhesive strength. - in vitro release of FB from FB-PLGA MS followed the Korsmeyer-Peppas model , –, and the in situ gel preparation was found to be compatible with the Peppas-Sahlin model. In addition, MTT analysis of the ARPE-19 cell line revealed that the in situ gel formulation was biocompatible.

Conclusion: Flurbiprofen release was sustained, ocular availability was improved, and residence time was increased when flurbiprofen-loaded microspheres were incorporated into in situ gel bases.


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APA

Polat, H.K., & Ünal, S. (2024). Flurbiprofen-encapsulated microsphere laden into heat-triggered situ gel for ocular delivery. İstanbul Journal of Pharmacy, 54(2), 108-121. https://doi.org/10.26650/IstanbulJPharm.2024.1269717


AMA

Polat H K, Ünal S. Flurbiprofen-encapsulated microsphere laden into heat-triggered situ gel for ocular delivery. İstanbul Journal of Pharmacy. 2024;54(2):108-121. https://doi.org/10.26650/IstanbulJPharm.2024.1269717


ABNT

Polat, H.K.; Ünal, S. Flurbiprofen-encapsulated microsphere laden into heat-triggered situ gel for ocular delivery. İstanbul Journal of Pharmacy, [Publisher Location], v. 54, n. 2, p. 108-121, 2024.


Chicago: Author-Date Style

Polat, Heybet Kerem, and Sedat Ünal. 2024. “Flurbiprofen-encapsulated microsphere laden into heat-triggered situ gel for ocular delivery.” İstanbul Journal of Pharmacy 54, no. 2: 108-121. https://doi.org/10.26650/IstanbulJPharm.2024.1269717


Chicago: Humanities Style

Polat, Heybet Kerem, and Sedat Ünal. Flurbiprofen-encapsulated microsphere laden into heat-triggered situ gel for ocular delivery.” İstanbul Journal of Pharmacy 54, no. 2 (Nov. 2024): 108-121. https://doi.org/10.26650/IstanbulJPharm.2024.1269717


Harvard: Australian Style

Polat, HK & Ünal, S 2024, 'Flurbiprofen-encapsulated microsphere laden into heat-triggered situ gel for ocular delivery', İstanbul Journal of Pharmacy, vol. 54, no. 2, pp. 108-121, viewed 15 Nov. 2024, https://doi.org/10.26650/IstanbulJPharm.2024.1269717


Harvard: Author-Date Style

Polat, H.K. and Ünal, S. (2024) ‘Flurbiprofen-encapsulated microsphere laden into heat-triggered situ gel for ocular delivery’, İstanbul Journal of Pharmacy, 54(2), pp. 108-121. https://doi.org/10.26650/IstanbulJPharm.2024.1269717 (15 Nov. 2024).


MLA

Polat, Heybet Kerem, and Sedat Ünal. Flurbiprofen-encapsulated microsphere laden into heat-triggered situ gel for ocular delivery.” İstanbul Journal of Pharmacy, vol. 54, no. 2, 2024, pp. 108-121. [Database Container], https://doi.org/10.26650/IstanbulJPharm.2024.1269717


Vancouver

Polat HK, Ünal S. Flurbiprofen-encapsulated microsphere laden into heat-triggered situ gel for ocular delivery. İstanbul Journal of Pharmacy [Internet]. 15 Nov. 2024 [cited 15 Nov. 2024];54(2):108-121. Available from: https://doi.org/10.26650/IstanbulJPharm.2024.1269717 doi: 10.26650/IstanbulJPharm.2024.1269717


ISNAD

Polat, HeybetKerem - Ünal, Sedat. Flurbiprofen-encapsulated microsphere laden into heat-triggered situ gel for ocular delivery”. İstanbul Journal of Pharmacy 54/2 (Nov. 2024): 108-121. https://doi.org/10.26650/IstanbulJPharm.2024.1269717



TIMELINE


Submitted23.03.2023
Accepted27.07.2024
Published Online26.08.2024

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