İstanbul Journal of Pharmacy

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DOI :10.26650/IstanbulJPharm.2019.0026   IUP :10.26650/IstanbulJPharm.2019.0026    Full Text (PDF)

In vitro characterization of mucoadhesive polysaccharide polymers tablets fabricated using FTIR press

Ashwini Kumar, Sudhanshu Kumar Bharti, Awanish Kumar

Background and Aim: Buccal/sublingual drug delivery is gradually becoming one of the most experimented routes for alternate drug delivery. The major advantage of both routes is their high vascularity that allows a substantial permeation of drugs into systemic circulation. Mucoadhesive biopolymers are the mainstay of a transmucosal drug delivery system.

Methods: We formulated blank tablets of explored mucoadhesive biopolymers (sodium alginate, carboxymethyl cellulose, hydroxyl propyl methyl) cellulose using a combination of two at a time. The novelty of this script lies in the formation of tablets using the FTIR hydraulic press, as opposed toa conventional tablet punching machine, at two different pressures. The tablets were subjected to basic characterizations of polymeric interaction, hardness, and swelling behaviour.

Results: An interaction analysis using XRD revealed a good interaction between the polymers. HC-300 and AC-300 were found to be the hardest among the tablets formulated. In terms of swelling behaviour, AC-200 and HA-300 displayed the best swelling as compared to other combinations.

Conclusion: In the absence of a conventional tablet punching machine, we fabricated swellable biopolymeric tablets using the regular KBr hydraulic press that comes as an accessory with the FTIR instrument. These tablets can possible be used for delivering drugs through buccal mucosa.

Keywords: Biopolymer, FTIR press, tablets, drug delivery, transmucosal

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References

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Citations

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APA

Kumar, A., Bharti, S.K., & Kumar, A. (2020). In vitro characterization of mucoadhesive polysaccharide polymers tablets fabricated using FTIR press. İstanbul Journal of Pharmacy, 50(2), 79-82. https://doi.org/10.26650/IstanbulJPharm.2019.0026


AMA

Kumar A, Bharti S K, Kumar A. In vitro characterization of mucoadhesive polysaccharide polymers tablets fabricated using FTIR press. İstanbul Journal of Pharmacy. 2020;50(2):79-82. https://doi.org/10.26650/IstanbulJPharm.2019.0026


ABNT

Kumar, A.; Bharti, S.K.; Kumar, A. In vitro characterization of mucoadhesive polysaccharide polymers tablets fabricated using FTIR press. İstanbul Journal of Pharmacy, [Publisher Location], v. 50, n. 2, p. 79-82, 2020.


Chicago: Author-Date Style

Kumar, Ashwini, and Sudhanshu Kumar Bharti and Awanish Kumar. 2020. “In vitro characterization of mucoadhesive polysaccharide polymers tablets fabricated using FTIR press.” İstanbul Journal of Pharmacy 50, no. 2: 79-82. https://doi.org/10.26650/IstanbulJPharm.2019.0026


Chicago: Humanities Style

Kumar, Ashwini, and Sudhanshu Kumar Bharti and Awanish Kumar. “In vitro characterization of mucoadhesive polysaccharide polymers tablets fabricated using FTIR press.” İstanbul Journal of Pharmacy 50, no. 2 (May. 2024): 79-82. https://doi.org/10.26650/IstanbulJPharm.2019.0026


Harvard: Australian Style

Kumar, A & Bharti, SK & Kumar, A 2020, 'In vitro characterization of mucoadhesive polysaccharide polymers tablets fabricated using FTIR press', İstanbul Journal of Pharmacy, vol. 50, no. 2, pp. 79-82, viewed 20 May. 2024, https://doi.org/10.26650/IstanbulJPharm.2019.0026


Harvard: Author-Date Style

Kumar, A. and Bharti, S.K. and Kumar, A. (2020) ‘In vitro characterization of mucoadhesive polysaccharide polymers tablets fabricated using FTIR press’, İstanbul Journal of Pharmacy, 50(2), pp. 79-82. https://doi.org/10.26650/IstanbulJPharm.2019.0026 (20 May. 2024).


MLA

Kumar, Ashwini, and Sudhanshu Kumar Bharti and Awanish Kumar. “In vitro characterization of mucoadhesive polysaccharide polymers tablets fabricated using FTIR press.” İstanbul Journal of Pharmacy, vol. 50, no. 2, 2020, pp. 79-82. [Database Container], https://doi.org/10.26650/IstanbulJPharm.2019.0026


Vancouver

Kumar A, Bharti SK, Kumar A. In vitro characterization of mucoadhesive polysaccharide polymers tablets fabricated using FTIR press. İstanbul Journal of Pharmacy [Internet]. 20 May. 2024 [cited 20 May. 2024];50(2):79-82. Available from: https://doi.org/10.26650/IstanbulJPharm.2019.0026 doi: 10.26650/IstanbulJPharm.2019.0026


ISNAD

Kumar, Ashwini - Bharti, SudhanshuKumar - Kumar, Awanish. “In vitro characterization of mucoadhesive polysaccharide polymers tablets fabricated using FTIR press”. İstanbul Journal of Pharmacy 50/2 (May. 2024): 79-82. https://doi.org/10.26650/IstanbulJPharm.2019.0026



TIMELINE


Submitted18.06.2019
Accepted31.03.2020
Published Online27.08.2020

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