İstanbul Journal of Pharmacy

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DOI :10.26650/IstanbulJPharm.2022.1027027   IUP :10.26650/IstanbulJPharm.2022.1027027    Full Text (PDF)

Obesogens: Definition, mechanisms of action, potential industrial chemicals and pharmaceuticals

Bita Entezari, Deniz Bozdağ, Hande Gürer Orhan

The incidence of obesity and related diseases has increased dramatically in the last decade. Some endocrine disruptors have been shown to interact with metabolic processes via various cellular mechanisms, and disrupt homeostasis in adipose tissue, resulting in weight gain and obesity. These chemicals are called “obesogens”. Today, with the increased use of industrial chemicals, individuals are exposed to a mixture of chemicals at very low doses. Most of these industrial chemicals have been investigated for their possible endocrine-disrupting and obesogenic effects. Besides these chemicals, pharmaceuticals can also have similar adverse effects; however, limited studies have been performed to investigate such effects of drugs. Furthermore, there are few studies investigating the relationship between prenatal exposure to pharmaceuticals and childhood obesity. Therefore, to clarify the endocrine-disrupting and obesogenic effects of the pharmaceuticals, which are prescribed during pregnancy, mechanistic studies should be performed, and necessary precautions should be taken. In this paper, we reviewed the mechanisms of obesogens, briefly overview several well-known obesogenic industrial chemicals, and focused more on potential obesogenic pharmaceuticals.

Keywords: Endocrine disruptors, Obesogens, Adipogenesis, Lipogenesis, Pharmaceuticals

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APA

Entezari, B., Bozdağ, D., & Gürer Orhan, H. (2022). Obesogens: Definition, mechanisms of action, potential industrial chemicals and pharmaceuticals. İstanbul Journal of Pharmacy, 52(2), 215-225. https://doi.org/10.26650/IstanbulJPharm.2022.1027027


AMA

Entezari B, Bozdağ D, Gürer Orhan H. Obesogens: Definition, mechanisms of action, potential industrial chemicals and pharmaceuticals. İstanbul Journal of Pharmacy. 2022;52(2):215-225. https://doi.org/10.26650/IstanbulJPharm.2022.1027027


ABNT

Entezari, B.; Bozdağ, D.; Gürer Orhan, H. Obesogens: Definition, mechanisms of action, potential industrial chemicals and pharmaceuticals. İstanbul Journal of Pharmacy, [Publisher Location], v. 52, n. 2, p. 215-225, 2022.


Chicago: Author-Date Style

Entezari, Bita, and Deniz Bozdağ and Hande Gürer Orhan. 2022. “Obesogens: Definition, mechanisms of action, potential industrial chemicals and pharmaceuticals.” İstanbul Journal of Pharmacy 52, no. 2: 215-225. https://doi.org/10.26650/IstanbulJPharm.2022.1027027


Chicago: Humanities Style

Entezari, Bita, and Deniz Bozdağ and Hande Gürer Orhan. “Obesogens: Definition, mechanisms of action, potential industrial chemicals and pharmaceuticals.” İstanbul Journal of Pharmacy 52, no. 2 (May. 2024): 215-225. https://doi.org/10.26650/IstanbulJPharm.2022.1027027


Harvard: Australian Style

Entezari, B & Bozdağ, D & Gürer Orhan, H 2022, 'Obesogens: Definition, mechanisms of action, potential industrial chemicals and pharmaceuticals', İstanbul Journal of Pharmacy, vol. 52, no. 2, pp. 215-225, viewed 18 May. 2024, https://doi.org/10.26650/IstanbulJPharm.2022.1027027


Harvard: Author-Date Style

Entezari, B. and Bozdağ, D. and Gürer Orhan, H. (2022) ‘Obesogens: Definition, mechanisms of action, potential industrial chemicals and pharmaceuticals’, İstanbul Journal of Pharmacy, 52(2), pp. 215-225. https://doi.org/10.26650/IstanbulJPharm.2022.1027027 (18 May. 2024).


MLA

Entezari, Bita, and Deniz Bozdağ and Hande Gürer Orhan. “Obesogens: Definition, mechanisms of action, potential industrial chemicals and pharmaceuticals.” İstanbul Journal of Pharmacy, vol. 52, no. 2, 2022, pp. 215-225. [Database Container], https://doi.org/10.26650/IstanbulJPharm.2022.1027027


Vancouver

Entezari B, Bozdağ D, Gürer Orhan H. Obesogens: Definition, mechanisms of action, potential industrial chemicals and pharmaceuticals. İstanbul Journal of Pharmacy [Internet]. 18 May. 2024 [cited 18 May. 2024];52(2):215-225. Available from: https://doi.org/10.26650/IstanbulJPharm.2022.1027027 doi: 10.26650/IstanbulJPharm.2022.1027027


ISNAD

Entezari, Bita - Bozdağ, Deniz - Gürer Orhan, Hande. “Obesogens: Definition, mechanisms of action, potential industrial chemicals and pharmaceuticals”. İstanbul Journal of Pharmacy 52/2 (May. 2024): 215-225. https://doi.org/10.26650/IstanbulJPharm.2022.1027027



TIMELINE


Submitted23.11.2021
Accepted15.04.2022
Published Online29.08.2022

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