İstanbul Journal of Pharmacy

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Research Article


DOI :10.26650/IstanbulJPharm.2025.1506618   IUP :10.26650/IstanbulJPharm.2025.1506618    Full Text (PDF)

Optimization of cleansing oil formulation containing polyglyceryl-6 caprylate and polyglyceryl-4 caprate using the response surface method

Ayşenur Kılıç, Burak Çelik

Background and Aims: Natural raw materials used in skin cleansing products have recently become popular. In this study, natural-origin raw materials were used to develop an oil-based cleanser formulation with high foaming ability and stable properties. The researchers attempted to obtain the optimum formulation by determining the optimised polyglyceryl-6 caprylate/polyglyceryl-4 caprate (PG-6/PG-4) ratio.

Methods: Cleansing formulations were prepared using caprylic/capric triglyceride (CCT), hemp seed oil, and PG-6/PG-4. The D-optimal response surface design was used to determine the optimum formulation component ratios. The foaming volumes and the transparency of the formulations were also evaluated. The pH and viscosity of the formulations were also measured. Stability tests of the formulations were carried out at 40oC and 75% relative humidity conditions for 2 months. The optimum component quantities were determined by the Design-Expert software.

Results: The ratios of the formulation components were found to be 4.3% for PG-6/PG-4, 5.6% for water, and 34.1% for CCT as optimised formulation. The foam volume was found to be 1.06 mL, and the transparency was observed to be 4 out of the maximum 5. The pH of the formulation was 6.61. It exhibited pseudoplastic flow properties, and as a result of stability studies, there were no significant changes in its pH, transparency, and foaming properties.

Conclusion: In this study, we obtained a cleansing product composed of natural compounds with acceptable properties and stability.

Keywords: Cosmetics, Experimental design, Hemp seed oil, Skincare, Surface-active agents

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APA

Kılıç, A., & Çelik, B. (2025). Optimization of cleansing oil formulation containing polyglyceryl-6 caprylate and polyglyceryl-4 caprate using the response surface method. İstanbul Journal of Pharmacy, 55(1), 85-92. https://doi.org/10.26650/IstanbulJPharm.2025.1506618


AMA

Kılıç A, Çelik B. Optimization of cleansing oil formulation containing polyglyceryl-6 caprylate and polyglyceryl-4 caprate using the response surface method. İstanbul Journal of Pharmacy. 2025;55(1):85-92. https://doi.org/10.26650/IstanbulJPharm.2025.1506618


ABNT

Kılıç, A.; Çelik, B. Optimization of cleansing oil formulation containing polyglyceryl-6 caprylate and polyglyceryl-4 caprate using the response surface method. İstanbul Journal of Pharmacy, [Publisher Location], v. 55, n. 1, p. 85-92, 2025.


Chicago: Author-Date Style

Kılıç, Ayşenur, and Burak Çelik. 2025. “Optimization of cleansing oil formulation containing polyglyceryl-6 caprylate and polyglyceryl-4 caprate using the response surface method.” İstanbul Journal of Pharmacy 55, no. 1: 85-92. https://doi.org/10.26650/IstanbulJPharm.2025.1506618


Chicago: Humanities Style

Kılıç, Ayşenur, and Burak Çelik. “Optimization of cleansing oil formulation containing polyglyceryl-6 caprylate and polyglyceryl-4 caprate using the response surface method.” İstanbul Journal of Pharmacy 55, no. 1 (Aug. 2025): 85-92. https://doi.org/10.26650/IstanbulJPharm.2025.1506618


Harvard: Australian Style

Kılıç, A & Çelik, B 2025, 'Optimization of cleansing oil formulation containing polyglyceryl-6 caprylate and polyglyceryl-4 caprate using the response surface method', İstanbul Journal of Pharmacy, vol. 55, no. 1, pp. 85-92, viewed 17 Aug. 2025, https://doi.org/10.26650/IstanbulJPharm.2025.1506618


Harvard: Author-Date Style

Kılıç, A. and Çelik, B. (2025) ‘Optimization of cleansing oil formulation containing polyglyceryl-6 caprylate and polyglyceryl-4 caprate using the response surface method’, İstanbul Journal of Pharmacy, 55(1), pp. 85-92. https://doi.org/10.26650/IstanbulJPharm.2025.1506618 (17 Aug. 2025).


MLA

Kılıç, Ayşenur, and Burak Çelik. “Optimization of cleansing oil formulation containing polyglyceryl-6 caprylate and polyglyceryl-4 caprate using the response surface method.” İstanbul Journal of Pharmacy, vol. 55, no. 1, 2025, pp. 85-92. [Database Container], https://doi.org/10.26650/IstanbulJPharm.2025.1506618


Vancouver

Kılıç A, Çelik B. Optimization of cleansing oil formulation containing polyglyceryl-6 caprylate and polyglyceryl-4 caprate using the response surface method. İstanbul Journal of Pharmacy [Internet]. 17 Aug. 2025 [cited 17 Aug. 2025];55(1):85-92. Available from: https://doi.org/10.26650/IstanbulJPharm.2025.1506618 doi: 10.26650/IstanbulJPharm.2025.1506618


ISNAD

Kılıç, Ayşenur - Çelik, Burak. “Optimization of cleansing oil formulation containing polyglyceryl-6 caprylate and polyglyceryl-4 caprate using the response surface method”. İstanbul Journal of Pharmacy 55/1 (Aug. 2025): 85-92. https://doi.org/10.26650/IstanbulJPharm.2025.1506618



TIMELINE


Submitted28.06.2024
Accepted16.09.2024
Published Online07.05.2025

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