Review


DOI :10.5152/IstanbulJPharm.2018.424278   IUP :10.5152/IstanbulJPharm.2018.424278    Full Text (PDF)

Overview on nanotechnology based cosmeceuticals to prevent skin aging

Gizem OtlatıcıGizem YeğenSevgi GüngörBuket Aksu

Skin aging is an inevitable process and the highest contributing factor to this process is the effect of ultraviolet rays. However, nutrients, dry skin, smoking, hormones and gravity are also other important factors. Skin aging is classified as intrinsic (chronological) and extrinsic (photo-aging). Generally, in aged skin, effects such as thinning, loss of elasticity, spotting, wrinkles and sagging are observed. There are various approaches to preventing skin aging. The most widely used age combating substances in cosmeceuticals are kinetin, retinoids, sun filters, herbal ingredients (such as resveratrol, turmeric, and green tea), and antioxidants (such as alpha-tocopherol, ascorbic acid, coenzyme Q10 and lipoic acid). In recent years, these molecules have been formulated as nanosized carriers such as vesicular systems, polymeric and lipid nanoparticles, nanoemulsions, dendrimers, and fullerenes. Novel carrier systems have a lot of advantages when compared to conventional formulations. In this review, an overview of cosmetic, product-oriented solutions for skin aging is given and different approaches to combat aging are summarized.


PDF View

References

  • Allemann IB, Baumann, L. (2009). Botanicals in skin care products. 48(9): 923-934. google scholar
  • Bakry R, Vallant RM, Najam-ul-Haq M, Rainer M, Szabo Z, Huck CW, Bonn GK. (2007). Medicinal applications of fullerenes. 2(4): 639. google scholar
  • Baroni A, Buommino E, De Gregorio V, Ruocco E, Ruocco V, Wolf R. (2012). Structure and function of the epidermis related to barrier properties. 30(3), 257-262. google scholar
  • Barry BW. Penetration enhancers. In: Shroot B, Schafer H, 1987 editors. Skin Pharmacokinetics. Karger, Basel. pp. 121-7 google scholar
  • Benson HA, Watkinson AC. (Eds.). (2012). Topical and transdermal drug delivery: Principles and practice. John Wiley & Sons. google scholar
  • Bouwstra JA, Honeywell-Nguyen PL. (2002). Skin structure and mode of action of vesicles. 54: S41-S55. google scholar
  • Chanchal D, Swarnlata S. (2008). Novel approaches in herbal cosmetics. J Cosmet Dermatol 7(2): 89-95. google scholar
  • Chasteen AL, Bashir NY, Gallucci C, Visekruna A. (2011). Age and antiaging technique influence reactions to age concealment. 66(6): 719-724. google scholar
  • Darlenski R, Fluhr JW. (2012). Influence of skin type, race, sex, and anatomic location on epidermal barrier function. 30(3): 269-273. google scholar
  • Ezzat SM, Salama MM, ElMeshad AN, Teaima MH, Rashad LA. (2016). HPLC–DAD–MS/MS profiling of standardized rosemary extract and enhancement of its anti-wrinkle activity by encapsulation in elastic nanovesicles. 39(7): 912-925. google scholar
  • Farage MA, Miller KW, Elsner P, Maibach HI. (2007). Structural characteristics of the aging skin: a review. 26(4): 343-357. google scholar
  • Friedrich RB, Kann B, Coradini K, Offerhaus HL, Beck RC, Windbergs M. (2015). Skin penetration behavior of lipid-core nanocapsules for simultaneous delivery of resveratrol and curcumin. 78: 204-213 google scholar
  • Goindi S, Guleria A, Aggarwal N. (2015). Development and Evaluation of Solid Lipid Nanoparticles of N-6-Furfuryl Adenine for Prevention of Photoaging. 11(10): 1734-1746. google scholar
  • Gökce EH, Korkmaz E, Dellera E, Sandri G, Bonferoni MC, Ozer O. (2012). Resveratrol-loaded solid lipid nanoparticles versus nanostructured lipid carriers: evaluation of antioxidant potential for dermal applications. 7(1), 1841-1850. google scholar
  • Gondikas AP, Kammer FVD, Reed RB, Wagner S, Ranville JF, Hofmann T. (2014). Release of TiO2 nanoparticles from sunscreens into surface waters: a one-year survey at the old Danube recreational Lake. 48(10): 5415-5422. google scholar
  • Graf J. (2005). Anti-aging skin care ingredient technologies. In: Cosmetic Dermatology Springer, Berlin Heidelberg. pp. 17-28. google scholar
  • Guimarães KL, Ré MI. (2011). Lipid nanoparticles as carriers for cosmetic ingredients: The first (SLN) and the second generation (NLC). In: Nanocosmetics and nanomedicines, Springer, Berlin Heidelberg. pp. 101-122. google scholar
  • Gupta M, Agrawal U, Vyas SP. (2012). Nanocarrier-based topical drug delivery for the treatment of skin diseases. 9(7): 783-804. google scholar
  • Gupta NK, Dixit VK. (2011). Development and evaluation of vesicular system for curcumin delivery. 303(2): 89-101. google scholar
  • Guterres SS, Alves MP, Pohlmann AR. (2007). Polymeric nanoparticles, nanospheres and nanocapsules, for cutaneous applications. 2: 147-157. google scholar
  • Güngör S, Erdal MS, Aksu B. (2013). New formulation strategies in topical antifungal therapy. 3(01): 56-65. google scholar
  • Güngör S. (2014). Topikal Uygulanan Nanotaşıyıcılar, In: Zırh-Gürsoy A (ed.) Nanofarmasötikler ve Uygulamaları. Aktif Matbaa ve Reklam Hiz. San. Tic. A.Ş. İstanbul, pp. 333-345. google scholar
  • Jaspart S, Piel G, Delattre L, Evrard B. (2005). Solid lipid microparticles: formulation, preparation, characterisation, drug release and applications. 2(1): 75-87. google scholar
  • Kahraman E, Özhan G, Özsoy Y, Güngör S. (2016). Polymeric micellar nanocarriers of benzoyl peroxide as potential follicular targeting approach for acne treatment. 146: 692-699. google scholar
  • Kandekar SG, Del Río-Sancho S, Lapteva M, Kalia YN. (2018). Selective delivery of adapalene to the human hair follicle under finite dose conditions using polymeric micelle nanocarriers. 10(3): 1099-1110. google scholar
  • Kaur CD, Saraf S. (2011). Topical vesicular formulations of Curcuma longa extract on recuperating the ultraviolet radiation–damaged skin. 10(4): 260-265. google scholar
  • Kaur IP, Agrawal R. (2007). Nanotechnology: a new paradigm in cosmeceuticals. 1(2): 171-182 google scholar
  • Kaur IP, Kapila M, Agrawal R. (2007). Role of novel delivery systems in developing topical antioxidants as therapeutics to combat photoageing. 6(4): 271-288. google scholar
  • Kwon SS, Kim SY, Kong BJ, Kim KJ, Noh GY, Im NR, Park SN. (2015). Cell penetrating peptide conjugated liposomes as transdermal delivery system of Polygonumaviculare L. extract. 483(1): 26-37. google scholar
  • Lazarus, M. C., & Baumann, L. S. (2001). The use of cosmeceutical moisturizers. 14(3): 200-207. google scholar
  • Li D, Wu Z, Martini N, Wen J. (2011). Advanced carrier systems in cosmetics and cosmeceuticals: a review. 62(6): 549. google scholar
  • Manosroi A, Chutoprapat R, Abe M, Manosroi W, Manosroi J. (2012). Anti-aging efficacy of topical formulations containing niosomes entrapped with rice bran bioactive compounds. 50(2): 208-224. google scholar
  • McCullough JL, Kelly KM. (2006). Prevention and treatment of skin aging. 1067(1): 323-331. google scholar
  • Morganti, P. (2010). Use and potential of nanotechnology in cosmetic dermatology. Clin Cosmet Investig Dermatol 3: 5-13. google scholar
  • Müller RH. (1991). Colloidal carriers for controlled drug delivery and targeting: Modification, characterization and in vivo distribution. Taylor & Francis. google scholar
  • Müller RH, Petersen RD, Hommoss A, Pardeike J. (2007). Nanostructured lipid carriers (NLC) in cosmetic dermal products. 59(6): 522-530 google scholar
  • Müller RH, Radtke M, Wissing SA. (2002). Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. 54: S131-S155. google scholar
  • Nacht S, Katz M. The microsponge: A novel topical programmable delivery system. (1990).In: Osborne DW, Amman AH, editors. Topical Drug Delivery Formulations. Marcel Dekker Basel, New York. p. 299-325 google scholar
  • Pando D, Caddeo C, Manconi M, Fadda AM, Pazos C. (2013). Nanodesign of olein vesicles for the topical delivery of the antioxidant resveratrol. 65(8): 1158-1167. google scholar
  • Piccioni A, Fargnoli MC, Schoinas S, Suppa M, Frascione P, Ginebri A, Peris K. (2011). Efficacy and tolerability of 5-aminolevulinic acid 0.5% liposomal spray and intense pulsed light in wrinkle reduction of photodamaged skin. 22(5): 247-253. google scholar
  • Pradhan SK. (2011). Microsponges as the versatile tool for drug delivery system. 1(2), 243-58. google scholar
  • Proksch E, Brandner JM, Jensen JM. (2008). The skin: an indispensable barrier. 17(12): 1063-1072. google scholar
  • Rahimpour Y, Hamishehkar H. (2012). Liposomes in cosmeceutics. 9(4): 443-455. google scholar
  • Ramos-e-Silva M, Jacques CDMC. (2012). Epidermal barrier function and systemic diseases. 30(3): 277-279. google scholar
  • Schwarz JC, Baisaeng N, Hoppel M, Löw M, Keck CM, Valenta C. (2013). Ultra-small NLC for improved dermal delivery of coenyzme Q10. 447(1): 213-217. google scholar
  • Shakeel F, Shafiq S, Haq N, Alanazi FK, Alsarra IA. (2012). Nanoemulsions as potential vehicles for transdermal and dermal delivery of hydrophobic compounds: an overview. 9(8): 953-974. google scholar
  • Sharma B, Sharma A. (2012). Future prospect of nanotechnology in development of anti-ageing formulations. 4: 57-66. google scholar
  • Sherif S, Bendas ER, Badawy S. (2014). The clinical efficacy of cosmeceutical application of liquid crystalline nanostructured dispersions of alpha lipoic acid as anti-wrinkle. 86(2): 251-259. google scholar
  • Sinico C, Fadda AM. (2009). Vesicular carriers for dermal drug delivery. 6(8): 813-825. google scholar
  • Sorg O, Kuenzli S, Kaya G, Saurat JH. (2005). Proposed mechanisms of action for retinoid derivatives in the treatment of skin aging. 4(4): 237-244. google scholar
  • Tao L. (2000). Skin delivery from lipid vesicles. 115(4): 43-50. google scholar
  • Tarımcı N, Badıllı U S. (2014). Nanotaşıyıcıların Kozmetik Uygulamaları, In: Zırh-Gürsoy A (ed.) Nanofarmasötikler ve Uygulamaları. Aktif Matbaa ve Reklam Hiz. San. Tic. A.Ş. İstanbul, pp. 347-359. google scholar
  • Tırnaksız F. (2005). Antioksidanların cilt bakım ürünlerinde kullanımı. Teb Meslek içi Eğitim Dergisi. Kasım, pp. 26-37. google scholar
  • Touitou E, Dayan N, Bergelson L, Godin B, Eliaz M. (2000). Ethosomes—novel vesicular carriers for enhanced delivery: characterization and skin penetration properties. 65(3): 403-418. google scholar
  • Türsen Ü. (2006). Deri Yaşlanmasının Topikal Ajanlarla Önlenmesi. 4: 267-283. google scholar
  • Ünlü E. (2010). Erdem C. Deri yaşlanmasında korunma ve tedavi yöntemleri. 1(1), 23-31. google scholar
  • Wickett RR, Visscher MO. (2006). Structure and function of the epidermal barrier. 34(10): S98-S110. google scholar
  • Yadav NK, Nanda S, Sharma G, Katare OP. (2016). Systematically optimized coenzyme q10-loaded novel proniosomal formulation for treatment of photo-induced aging in mice: characterization, biocompatibility studies, biochemical estimations and anti-aging evaluation. 24(3): 257-271. google scholar
  • Yang D, Pornpattananangkul D, Nakatsuji T, Chan M, Carson D, Huang CM, Zhang L. (2009). The antimicrobial activity of liposomal lauric acids against Propionibacterium acnes. 30(30): 6035-6040. google scholar
  • Yapar EA, Tanrıverdi ST. (2016). Yaşlanma Karşıtı Kozmetik Yaklaşımlar ve Ürün Bileşenleri. ıkesir Sağlık Bilimleri Dergisi 5(2): 99-109. google scholar
  • Yazan Y. (2004). Kozmetik Bilimi. Nobel Tıp Kitabevleri/İstanbul. google scholar
  • Yazan Y. (2016). Dermakozmetik/Kozmesötik Madde ve Ürünler. Nobel Tıp Kitabevleri/İstanbul. google scholar
  • Yue Y, Zhou H, Liu G, Li Y, Yan Z, Duan M. (2010). The advantages of a novel CoQ10 delivery system in skin photo-protection. 392(1): 57-63. google scholar
  • Zussman J, Ahdout J, Kim J. (2010). Vitamins and photoaging: Do scientific data support their use? 63(3): 507-525. google scholar

Citations

Copy and paste a formatted citation or use one of the options to export in your chosen format


EXPORT



APA

Otlatıcı, G., Yeğen, G., Güngör, S., & Aksu, B. (2018). Overview on nanotechnology based cosmeceuticals to prevent skin aging. İstanbul Journal of Pharmacy, 48(2), 55-62. https://doi.org/10.5152/IstanbulJPharm.2018.424278


AMA

Otlatıcı G, Yeğen G, Güngör S, Aksu B. Overview on nanotechnology based cosmeceuticals to prevent skin aging. İstanbul Journal of Pharmacy. 2018;48(2):55-62. https://doi.org/10.5152/IstanbulJPharm.2018.424278


ABNT

Otlatıcı, G.; Yeğen, G.; Güngör, S.; Aksu, B. Overview on nanotechnology based cosmeceuticals to prevent skin aging. İstanbul Journal of Pharmacy, [Publisher Location], v. 48, n. 2, p. 55-62, 2018.


Chicago: Author-Date Style

Otlatıcı, Gizem, and Gizem Yeğen and Sevgi Güngör and Buket Aksu. 2018. “Overview on nanotechnology based cosmeceuticals to prevent skin aging.” İstanbul Journal of Pharmacy 48, no. 2: 55-62. https://doi.org/10.5152/IstanbulJPharm.2018.424278


Chicago: Humanities Style

Otlatıcı, Gizem, and Gizem Yeğen and Sevgi Güngör and Buket Aksu. Overview on nanotechnology based cosmeceuticals to prevent skin aging.” İstanbul Journal of Pharmacy 48, no. 2 (Jun. 2025): 55-62. https://doi.org/10.5152/IstanbulJPharm.2018.424278


Harvard: Australian Style

Otlatıcı, G & Yeğen, G & Güngör, S & Aksu, B 2018, 'Overview on nanotechnology based cosmeceuticals to prevent skin aging', İstanbul Journal of Pharmacy, vol. 48, no. 2, pp. 55-62, viewed 4 Jun. 2025, https://doi.org/10.5152/IstanbulJPharm.2018.424278


Harvard: Author-Date Style

Otlatıcı, G. and Yeğen, G. and Güngör, S. and Aksu, B. (2018) ‘Overview on nanotechnology based cosmeceuticals to prevent skin aging’, İstanbul Journal of Pharmacy, 48(2), pp. 55-62. https://doi.org/10.5152/IstanbulJPharm.2018.424278 (4 Jun. 2025).


MLA

Otlatıcı, Gizem, and Gizem Yeğen and Sevgi Güngör and Buket Aksu. Overview on nanotechnology based cosmeceuticals to prevent skin aging.” İstanbul Journal of Pharmacy, vol. 48, no. 2, 2018, pp. 55-62. [Database Container], https://doi.org/10.5152/IstanbulJPharm.2018.424278


Vancouver

Otlatıcı G, Yeğen G, Güngör S, Aksu B. Overview on nanotechnology based cosmeceuticals to prevent skin aging. İstanbul Journal of Pharmacy [Internet]. 4 Jun. 2025 [cited 4 Jun. 2025];48(2):55-62. Available from: https://doi.org/10.5152/IstanbulJPharm.2018.424278 doi: 10.5152/IstanbulJPharm.2018.424278


ISNAD

Otlatıcı, Gizem - Yeğen, Gizem - Güngör, Sevgi - Aksu, Buket. Overview on nanotechnology based cosmeceuticals to prevent skin aging”. İstanbul Journal of Pharmacy 48/2 (Jun. 2025): 55-62. https://doi.org/10.5152/IstanbulJPharm.2018.424278



TIMELINE


Accepted19.07.2018

LICENCE


Attribution-NonCommercial (CC BY-NC)

This license lets others remix, tweak, and build upon your work non-commercially, and although their new works must also acknowledge you and be non-commercial, they don’t have to license their derivative works on the same terms.


SHARE



Istanbul University Press aims to contribute to the dissemination of ever growing scientific knowledge through publication of high quality scientific journals and books in accordance with the international publishing standards and ethics. Istanbul University Press follows an open access, non-commercial, scholarly publishing.