İstanbul Journal of Pharmacy

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DOI :10.26650/IstanbulJPharm.2022.1011516   IUP :10.26650/IstanbulJPharm.2022.1011516    Full Text (PDF)

Relationship of thiol/disulphide homeostasis with oxidative stress parameters in non-diabetic, prediabetic and type 2 diabetic Turkish women

Ayşe Ceylan Hamamcıoğlu, Çınar Severcan, Taner Bayraktaroğlu

Background and Aims: Deterioration of thiol/disulphide homeostasis (TDH) is found in several diseases, including diabetes. This study aimed to examine the association between TDH and oxidative stress parameters in nondiabetics, prediabetics and newly diagnosed type 2 diabetics. Methods: A total of 26 non-diabetic, 24 prediabetic and 19 type 2 diabetic women were involved in our study. They all applied to Zonguldak Bulent Ecevit University, Health Practice and Research Center, Endocrinology and Metabolism Diseases, Diabetes Polyclinic to be tested for type 2 diabetes mellitus. The demographic and laboratory data were collected from the patient files. Oxidative stress parameters and dynamic TDH were investigated using ELISA kits. Results: Total oxidant status (TOS), total thiol and disulphide levels were significantly higher in type 2 diabetics than the non-diabetics (24.24±14.93 versus 14.14±12.19, 646.47±75.51 versus 470.88±180.85, and 179.32±51.24 versus 91.85±40.29, respectively). In type 2 diabetics, a positive correlation between TOS and native thiol, total thiol and disulphide levels was found (P=0.000). In prediabetics, a significant positive correlation was found between total antioxidant capacity and total thiol levels (P<0.05), and also between arylesterase and native and total thiol levels (P<0.05). Conclusion: The elevation of oxidative stress and the deterioration of TDH might cause the formation of symptoms related to high blood glucose levels in type 2 diabetics.

Keywords: Sulfhydryl compounds, Diabetes mellitus, type 2, Prediabetic state, Oxidative stress

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References

  • Agan, V., Celik, H., Eren, M. A., Agan, F. Z., Erel, O., Neselioglu, S. ... Gonel, A. (2019). An investigation of oxidative stress and thiol/ disulphide homeostasis in graves’ disease. Medicina (Kaunas), 55, 275-287. http://dx.doi.org/10.3390/medicina55060275. google scholar
  • Aktun, L. H., Aykanat, Y., Erel, O., Neselioglu, S., & Olmuscelik, O. (2018). A study over thiol disulphide homeostasis in cord blood in women with gestational diabetes. Jounal of Family and Reproduc-tive Health, 12, 217-222. google scholar
  • Aldemir, M., Karaguzel, E., Okulu, E., Gudeloglu, A., Ener, K., Ozayar, A., & Erel, O. (2015). Evaluation of oxidative stress status and anti-oxidant capacity in patients with renal cell carcinoma. Central Eu-ropean Journal of Urology, 68, 415-420. http://dx.doi.org/10.5173/ ceju.2015.656. google scholar
  • Ates, I., Kaplan, M., Inan, B., Alisik, M., Erel, O., Yilmaz, N., & Guler, S. (2015). How does thiol/disulphide homeostasis change in pre-diabetic patients? Diabetes Research and Clinical Practice, 110(2), 166-171. https://doi.Org/10.1016/j.diabres.2015.09.011. google scholar
  • Ates, I., Kaplan, M., Yuksel, M., Mese, D., Alisik, M., Erel, O. . Guler, S. (2016). Determination of thiol/disulphide homeostasis in type 1 diabetes mellitus and the factors associated with thiol oxida-tion. Endocrine, 51, 47-51. http://dx.doi.org/10.1007/ s12020-015-0784-6. google scholar
  • Aydogan, S., Akduman, H., Dilli, D., Koyuncu, E., Citli, R., Erel, O ... Zenciroglu A. (2021). The role of thiol-disulphide homeostasis in neonatal sepsis. The Journal of Maternal-Fetal & Neonatal Medicine, 34, 1522-1528. http://dx.doi.org/10.1080/14767058.2019.1638904. Bandeira, S., Guedes, G., da Fonseca, L. J., Pires, A. S., Gelain, D. P., Moreira, J. C. . Goulart, M. O. (2012). Characterization of blood oxidative stress in type 2 diabetes mellitus patients: increase in lipid peroxidation and SOD activity. Oxidative Medicine and Cellu-lar Longevity 2012, 819310. https://doi.org/10.1155/2012/819310. Dziegielewska-Gesiak, S., Wysocka, E., Michalak, S., Nowakowska-Zajdel, E., Kokot, T., & Muc-Wierzgon M. (2014). Role of lipid per-oxidation products, plasma total antioxidant status, and Cu-, Zn-superoxide dismutase activity as biomarkers of oxidative stress in elderly prediabetics. Oxidative Medicine and Cellular Longevity, 2014, 987303. https://doi.org/10.1155/2014/987303. google scholar
  • Eckerson, H.W., Wyte, C.M., & La Du, B.N. (1983). The human serum paraoxonase/arylesterase polymorphism. The American Journal of Human Genetics, 35, 1126-1138. google scholar
  • Eljaoudi, R., Elomri, N., Laamarti, M., Cherrah, Y., Amezyane, T., Ghafir D, & Ibrahimi, A. (2017). Antioxidants status in type 2 dia-betic patients in Morocco. Turkish Journal of Medical Sciences, 47, 782-788. http://dx.doi.org/10.3906/sag-1512-110. google scholar
  • Emre, S., Akoglu, G., Metin, A., Demirseren, D.D., Isikoglu, S., Oz-tekin, A. & Erel, O. (2016). The oxidant and antioxidant status in pityriasis rosea. Indian Journal of Dermatology, 61, 118-138. http:// dx.doi.org/10.4103/0019-5154.174073. google scholar
  • Erel, O. (2004). A novel automated direct measurement method for total antioxidant capacity using a new generation, more sta-ble ABTS radical cation. Clinical Biochemistry, 37, 277-285. http:// dx.doi.org/10.1016/j.clinbiochem.2003.11.015. google scholar
  • Erel, O. (2005). A new automated colorimetric method for mea-suring total oxidant status. Clinical Biochemistry, 38, 1103-1111. http://dx.doi.org/10.1016/j.clinbiochem.2005.08.008. google scholar
  • Erel, O., & Neselioglu, S. (2014). A novel and automated assay for thiol/disulphide homeostasis. Clinical Biochemistry, 47, 326-332. http://dx.doi.org/10.1016/j.clinbio chem.2014.09.026. google scholar
  • Erel, O., & Erdogan, S. (2020). Thiol-disulphide homeostasis: an integrated approach with biochemical and clinical aspects. Turk-ish Journal of Medical Sciences, 50(SI-2), 1728-1738. http://dx.doi. org/10.3906/sag-2003-64. google scholar
  • Ergin, M., Aydin, C., Yurt, E.F., Cakir, B., Erel, O. (2020). The variation of disulphides in the progression of type 2 diabetes mellitus. Ex-perimental and Clinical Endocrinology & Diabetes, 128 (2), 77-81. http://dx.doi.org/10.1055/s-0044-100376. google scholar
  • Garber, A.J., Abrahamson, M.J., Barzilay, J.I., Blonde, L., Bloomgar-den, Z.T., Bush, M.A. . Umpierrez,G.E. (2019). Consensus State-ment by The American Association of Clinical Endocrinologists and American College of Endocrinology on the Comprehen-sive Type 2 Diabetes Management Algorithm - 2019 Execu-tive Summary. Endocrinology Practice, 25, 69-100. http://dx.doi. org/10.4158/CS-2018-0535. google scholar
  • Gulpamuk, B., Tekin, K., Sonmez, K., Inanc, M., Neselioglu, S. .Yilmazbas, P. (2018). The significance of thiol/disulphide homeo-stasis and ischemia- modified albumin levels to assess the oxida-tive stress in patients with different stages of diabetes mellitus. Scandinavian Journal of Clinical Laboratory Investigation, 78, 136142. http://dx.doi.org/10.1080/003655132017.1422540. google scholar
  • Hamamcioglu, A.C. (2017). The role of oxidative stress and antioxi-dants in diabetes mellitus. Turkish Journal of Diabetes and Obesity, 1, 7-13. http://dx.doi.org/10.25048/tjdo.2017.2. google scholar
  • Harma, M., Harma, M., & Erel, O. (2003). Increased oxidative stress in patients with hydatidiform mole. Swiss Medical Weekly, 133, 563-566. google scholar
  • Karatas, M., Ozis, T. N., Buyuksekerci, M., Gunduzoz, M., Ozakıncı, O. G., . Erel, O. (2019). Thiol-disulphide homeostasis and ischemia-modified albumin levels as indicators of oxidative stress in weld-ers’ lung disease. Human & Experimental Toxicology, 38, 1227-1234. http://dx.doi.org/10.1177/0960327119871093. google scholar
  • Khetan, A. K., & Rajagopalan, S. (2018). Prediabetes. Canadian Journal of Cardiology, 34, 615-623. http://dx.doi.org/10.1016/j. cjca.2017.12.030 google scholar
  • Kilinc, F., Sener, S., Akbas, A., Metin, A., Kirbas, S., Neselioglu S., & Erel, O. (2016). Oxidative stress parameters in localized sclero-derma patients. Archives of Dermatological Research, 308, 625-629. http://dx.doi.org/10.1007/s00403-016-1682-3. google scholar
  • Kosecik, M., Erel, O., Sevinc, E., & Selek, S. (2005). Increased oxida-tive stress in children exposed to passive smoking. International Journal of Cardiology, 100, 61-64. http://dx.doi.org/10.1016/j. ijcard.2004.05.069. google scholar
  • Lovic, D., Piperidou, A., Zografou, I., Grassos, H., Pittaras, A., & Manolis, A. (2020). The growing epidemic of diabetes mellitus. Current Vascular Pharmacology, 18, 104-109. http://dx.doi.org/10 .2174/1570161117666190405165911. google scholar
  • Nair, A., & Nair, B. J. (2017). Comparative analysis of the oxidative stress and antioxidant status in type II diabetics and nondiabetics: A biochemical study. Journal of Oral and Maxillofacial Pathology, 21, 394-401. http://dx.doi.org/10.4103/jomfp. JOMFP_56_16. google scholar
  • Noack, B., Aslanhan, Z., Boue, J., Petig, C.,Teige, M., Schaper, F. ... Hannig, C. (2013). Potential association of paraoxonase-1, type 2 diabetes mellitus, and periodontitis. Journal of Periodontology, 84(5), 614-623. https://doi.org/10.1902/jop.2012.120062. google scholar
  • Rosenblat, M., Sapir, O., & Aviram, M. (2008). The paraoxonases: their role in disease development and xenobiotic metabolism. In B. Mack-ness, M. Mackness, M. Aviram & G. Paragh (Eds.), Glucose inactivates Paraoxonase 1 (PON1) and displaces it from high density lipoprotein (HDL) to a free PON1 form (pp.35-51). New York, USA: Springer. google scholar
  • Sies, H. (1997). Oxidative stress: oxidants and antioxidants. Experi-mental Physiology, 82, 291-295. http://dx.doi.org/10.1113/exp-physiol.1997.sp004024. google scholar
  • Sonmez, M. G., Kozanhan, B., Deniz, C. D., Iyisoy, M. S., Kilinc, M. T., Ecer, G. . Erel, O. (2019). Dynamic thiol/disulphide homeostasis as a novel indicator of oxidative stress in patients with urolithia-sis. Investigative and Clinical Urology, 60, 258-266. http://dx.doi. org/10.4111/icu.2019.60.4.258. google scholar
  • Sozer, V., Himmetoglu, S., Korkmaz, G. G., Kaya, S., Aydin, S., Yumuk, V. . Uzun, H. (2014). Paraoxonase, oxidized low density lipopro-tein, monocyte chemoattractant protein-1 and adhesion mol-ecules are associated with macrovascular complications in pa-tients with type 2 diabetes mellitus. Minerva Medica, 105, 237-244. Tas, S., Sarandol, E., & Dirican, M. (2014). Vitamin B6 supple-mentation improves oxidative stress and enhances serum paraoxonase/arylesterase activities in streptozotocin-induced diabetic rats. Scientific World Journal,2014, 351598. https://doi. org/10.1155/2014/351598. google scholar
  • Topal, I., Mertoglu, C., Surucu Kara, I., Gok, G., & Erel, O. (2019). Thi-ol-disulphide homeostasis, serum ferroxidase activity, and serum ischemia modified albumin levels in childhood iron deficiency anemia. Fetal and Pediatric Pathology, 38, 484-489. http://dx.doi.or g/10.1080/15513815.2019.1627626. google scholar
  • Unal, E., Eris, C., Kaya, B., Uzun, H., Cavdar, F., .,Titiz, I. (2012). Paraoxonase and arylesterase activities, lipid profile, and oxida-tive damage in experimental ischemic colitis model. Gastro-enterology Research and Practice, 2012, 2012-2017. https://doi. org/10.1155/2012/979506. google scholar
  • Wu, G., Fang, Y-Z., Yang, S., Lupton, J.R., & Turner, N.D. (2004). Gluta-thione Metabolism and Its Implications for Health. The Journal of Nutrition, 134(3), 489-492. https://doi.org/10.1093 /jn/134.3.489. google scholar
  • Yumru, M., Savas, H. A., Kalenderoglu, A., Bulut, M., Celik, H., & Erel, O (2009). Oxidative imbalance in bipolar disorder subtypes: a comparative study. Progress in Neuropsychopharmacology & Biological Psychiatry, 33, 1070-1074. http://dx.doi.org/10.1016/j. pnpbp.2009.06.005. google scholar
  • Zarei, M., Fakher, S., Tabei, S. M., Javanbakht, M. H., Derakhshanian, H., ...Djalali, M. (2016). Effects of vitamin A, C and E, or omega-3 fatty acid supplementation on the level of paraoxonase and arylesterase activity in streptozotocin-induced diabetic rats: an investigation of activities in plasma, and heart and liver ho-mogenates. Singapore Medical Journal, 57, 153-156. https://doi. org/10.11622/smedj.2015102. google scholar

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APA

Hamamcıoğlu, A.C., Severcan, Ç., & Bayraktaroğlu, T. (2022). Relationship of thiol/disulphide homeostasis with oxidative stress parameters in non-diabetic, prediabetic and type 2 diabetic Turkish women. İstanbul Journal of Pharmacy, 52(2), 121-128. https://doi.org/10.26650/IstanbulJPharm.2022.1011516


AMA

Hamamcıoğlu A C, Severcan Ç, Bayraktaroğlu T. Relationship of thiol/disulphide homeostasis with oxidative stress parameters in non-diabetic, prediabetic and type 2 diabetic Turkish women. İstanbul Journal of Pharmacy. 2022;52(2):121-128. https://doi.org/10.26650/IstanbulJPharm.2022.1011516


ABNT

Hamamcıoğlu, A.C.; Severcan, Ç.; Bayraktaroğlu, T. Relationship of thiol/disulphide homeostasis with oxidative stress parameters in non-diabetic, prediabetic and type 2 diabetic Turkish women. İstanbul Journal of Pharmacy, [Publisher Location], v. 52, n. 2, p. 121-128, 2022.


Chicago: Author-Date Style

Hamamcıoğlu, Ayşe Ceylan, and Çınar Severcan and Taner Bayraktaroğlu. 2022. “Relationship of thiol/disulphide homeostasis with oxidative stress parameters in non-diabetic, prediabetic and type 2 diabetic Turkish women.” İstanbul Journal of Pharmacy 52, no. 2: 121-128. https://doi.org/10.26650/IstanbulJPharm.2022.1011516


Chicago: Humanities Style

Hamamcıoğlu, Ayşe Ceylan, and Çınar Severcan and Taner Bayraktaroğlu. “Relationship of thiol/disulphide homeostasis with oxidative stress parameters in non-diabetic, prediabetic and type 2 diabetic Turkish women.” İstanbul Journal of Pharmacy 52, no. 2 (May. 2024): 121-128. https://doi.org/10.26650/IstanbulJPharm.2022.1011516


Harvard: Australian Style

Hamamcıoğlu, AC & Severcan, Ç & Bayraktaroğlu, T 2022, 'Relationship of thiol/disulphide homeostasis with oxidative stress parameters in non-diabetic, prediabetic and type 2 diabetic Turkish women', İstanbul Journal of Pharmacy, vol. 52, no. 2, pp. 121-128, viewed 18 May. 2024, https://doi.org/10.26650/IstanbulJPharm.2022.1011516


Harvard: Author-Date Style

Hamamcıoğlu, A.C. and Severcan, Ç. and Bayraktaroğlu, T. (2022) ‘Relationship of thiol/disulphide homeostasis with oxidative stress parameters in non-diabetic, prediabetic and type 2 diabetic Turkish women’, İstanbul Journal of Pharmacy, 52(2), pp. 121-128. https://doi.org/10.26650/IstanbulJPharm.2022.1011516 (18 May. 2024).


MLA

Hamamcıoğlu, Ayşe Ceylan, and Çınar Severcan and Taner Bayraktaroğlu. “Relationship of thiol/disulphide homeostasis with oxidative stress parameters in non-diabetic, prediabetic and type 2 diabetic Turkish women.” İstanbul Journal of Pharmacy, vol. 52, no. 2, 2022, pp. 121-128. [Database Container], https://doi.org/10.26650/IstanbulJPharm.2022.1011516


Vancouver

Hamamcıoğlu AC, Severcan Ç, Bayraktaroğlu T. Relationship of thiol/disulphide homeostasis with oxidative stress parameters in non-diabetic, prediabetic and type 2 diabetic Turkish women. İstanbul Journal of Pharmacy [Internet]. 18 May. 2024 [cited 18 May. 2024];52(2):121-128. Available from: https://doi.org/10.26650/IstanbulJPharm.2022.1011516 doi: 10.26650/IstanbulJPharm.2022.1011516


ISNAD

Hamamcıoğlu, AyşeCeylan - Severcan, Çınar - Bayraktaroğlu, Taner. “Relationship of thiol/disulphide homeostasis with oxidative stress parameters in non-diabetic, prediabetic and type 2 diabetic Turkish women”. İstanbul Journal of Pharmacy 52/2 (May. 2024): 121-128. https://doi.org/10.26650/IstanbulJPharm.2022.1011516



TIMELINE


Submitted18.10.2021
Accepted28.07.2022
Published Online29.08.2022

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