Original Research


DOI :10.26650/IstanbulJPharm.2020.0003   IUP :10.26650/IstanbulJPharm.2020.0003    Full Text (PDF)

Spectrophotometric determinations of most commonly used statins in pharmaceutical preparations with 2,3-dichloro-5,6-dicyanobenzoquinone

Gamze Ergin KızılçaySıdıka Ertürk Toker

Background and Aims: In this study, simple, accurate and precise spectrophotometric methods were developed for the determination of five 3-hydroxy-3-methylglutaryl-coenzyme-A (HMG-CoA) reductase inhibitors in pure and pharmaceutical dosage forms.

Methods: In the developed methods, atorvastatin fluvastatin, pitavastatin, rosuvastatin and simvastatin were used in this class of drugs called statins. The methods were based on the charge-transfer reaction of n-electron donor drugs with π-acceptor 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ). All variables such as temperature, time, reaction medium, amount of reagent were examined for optimal formation of complexes to be given by the drugs with DDQ and optimal conditions were determined.

Results: The linearity ranges for atorvastatin, fluvastatin, pitavastatin, rosuvastatin and simvastatin were found to be 0.5-50, 1-6, 2.5-50, 5-25 and 5-50 µg/mL, respectively.

Conclusion: The proposed methods were successfully applied to both the pure and the pharmaceutical dosage forms.


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APA

Kızılçay, G.E., & Ertürk Toker, S. (2020). Spectrophotometric determinations of most commonly used statins in pharmaceutical preparations with 2,3-dichloro-5,6-dicyanobenzoquinone. İstanbul Journal of Pharmacy, 50(2), 95-102. https://doi.org/10.26650/IstanbulJPharm.2020.0003


AMA

Kızılçay G E, Ertürk Toker S. Spectrophotometric determinations of most commonly used statins in pharmaceutical preparations with 2,3-dichloro-5,6-dicyanobenzoquinone. İstanbul Journal of Pharmacy. 2020;50(2):95-102. https://doi.org/10.26650/IstanbulJPharm.2020.0003


ABNT

Kızılçay, G.E.; Ertürk Toker, S. Spectrophotometric determinations of most commonly used statins in pharmaceutical preparations with 2,3-dichloro-5,6-dicyanobenzoquinone. İstanbul Journal of Pharmacy, [Publisher Location], v. 50, n. 2, p. 95-102, 2020.


Chicago: Author-Date Style

Kızılçay, Gamze Ergin, and Sıdıka Ertürk Toker. 2020. “Spectrophotometric determinations of most commonly used statins in pharmaceutical preparations with 2,3-dichloro-5,6-dicyanobenzoquinone.” İstanbul Journal of Pharmacy 50, no. 2: 95-102. https://doi.org/10.26650/IstanbulJPharm.2020.0003


Chicago: Humanities Style

Kızılçay, Gamze Ergin, and Sıdıka Ertürk Toker. Spectrophotometric determinations of most commonly used statins in pharmaceutical preparations with 2,3-dichloro-5,6-dicyanobenzoquinone.” İstanbul Journal of Pharmacy 50, no. 2 (May. 2024): 95-102. https://doi.org/10.26650/IstanbulJPharm.2020.0003


Harvard: Australian Style

Kızılçay, GE & Ertürk Toker, S 2020, 'Spectrophotometric determinations of most commonly used statins in pharmaceutical preparations with 2,3-dichloro-5,6-dicyanobenzoquinone', İstanbul Journal of Pharmacy, vol. 50, no. 2, pp. 95-102, viewed 20 May. 2024, https://doi.org/10.26650/IstanbulJPharm.2020.0003


Harvard: Author-Date Style

Kızılçay, G.E. and Ertürk Toker, S. (2020) ‘Spectrophotometric determinations of most commonly used statins in pharmaceutical preparations with 2,3-dichloro-5,6-dicyanobenzoquinone’, İstanbul Journal of Pharmacy, 50(2), pp. 95-102. https://doi.org/10.26650/IstanbulJPharm.2020.0003 (20 May. 2024).


MLA

Kızılçay, Gamze Ergin, and Sıdıka Ertürk Toker. Spectrophotometric determinations of most commonly used statins in pharmaceutical preparations with 2,3-dichloro-5,6-dicyanobenzoquinone.” İstanbul Journal of Pharmacy, vol. 50, no. 2, 2020, pp. 95-102. [Database Container], https://doi.org/10.26650/IstanbulJPharm.2020.0003


Vancouver

Kızılçay GE, Ertürk Toker S. Spectrophotometric determinations of most commonly used statins in pharmaceutical preparations with 2,3-dichloro-5,6-dicyanobenzoquinone. İstanbul Journal of Pharmacy [Internet]. 20 May. 2024 [cited 20 May. 2024];50(2):95-102. Available from: https://doi.org/10.26650/IstanbulJPharm.2020.0003 doi: 10.26650/IstanbulJPharm.2020.0003


ISNAD

Kızılçay, GamzeErgin - Ertürk Toker, Sıdıka. Spectrophotometric determinations of most commonly used statins in pharmaceutical preparations with 2,3-dichloro-5,6-dicyanobenzoquinone”. İstanbul Journal of Pharmacy 50/2 (May. 2024): 95-102. https://doi.org/10.26650/IstanbulJPharm.2020.0003



TIMELINE


Submitted13.02.2020
Accepted03.06.2020
Published Online27.08.2020

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