İstanbul Journal of Pharmacy

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DOI :10.26650/IstanbulJPharm.2023.1266118   IUP :10.26650/IstanbulJPharm.2023.1266118    Full Text (PDF)

Synthesis, characterization and in vitro cytotoxic activity of platinum(II) oxalato complexes involving 2-substitutedimidazole or 2-substitutedbenzimidazole derivatives as carrier ligands

Emine Merve Ertuğrul, Azime Berna Özçelik, Nebahat Aytuna Çerçi, Leyla Açık, Semra Utku

Background and Aims: Cisplatin is currently one of the most widely used anticancer drugs in the world. However, its clinical usefulness has frequently been limited by severe side effects, such as nephrotoxicity, ototoxicity and neurotoxicity. Therefore, platinum(II) oxalato complexes with substitute imidazole or benzimidazole carrier ligands were synthesized and their cytotoxic effects were investigated against non-small cell lung cancer (H1299) and human colon adenocarcinoma (CaCo-2), and mouse fibroblast cells lines (L929).

Methods: Four platinum(II) complexes, [Pt(L1-L4)2(oxalate)] were synthesized and characterized by FT-IR, 1H NMR and elemental analyses. The MTT method was used to determine the potential antiproliferative effect of synthesized platinum(II) complexes and positive controls.

Results: In this study, the cytotoxic activity of platinum(II) complexes against tested cell lines was assessed, with moderate IC50 values. According to IC50 values, Complex 5 with 2-ethylbenzimidazole ligand was found to be the most active complex against H1299 and CaCo-2 cell lines. In general, the compounds are also promising drug candidates for H1299 cell lines with very low activity against the CaCo-2 cell lines.

Conclusion: Further modification and development of Complex 4 and 5 derivatives and in vitro cytotoxic activity studies against different cancer cell lines may lead to the emergence of new anticancer agents in the near future.

Keywords: Cytotoxic activity, 2-ethylbenzimidazole, 2-methylbenzimidazole, 2-phenylimidazole, platinum(II) complexes

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APA

Ertuğrul, E.M., Özçelik, A.B., Çerçi, N.A., Açık, L., & Utku, S. (2023). Synthesis, characterization and in vitro cytotoxic activity of platinum(II) oxalato complexes involving 2-substitutedimidazole or 2-substitutedbenzimidazole derivatives as carrier ligands. İstanbul Journal of Pharmacy, 53(3), 308-313. https://doi.org/10.26650/IstanbulJPharm.2023.1266118


AMA

Ertuğrul E M, Özçelik A B, Çerçi N A, Açık L, Utku S. Synthesis, characterization and in vitro cytotoxic activity of platinum(II) oxalato complexes involving 2-substitutedimidazole or 2-substitutedbenzimidazole derivatives as carrier ligands. İstanbul Journal of Pharmacy. 2023;53(3):308-313. https://doi.org/10.26650/IstanbulJPharm.2023.1266118


ABNT

Ertuğrul, E.M.; Özçelik, A.B.; Çerçi, N.A.; Açık, L.; Utku, S. Synthesis, characterization and in vitro cytotoxic activity of platinum(II) oxalato complexes involving 2-substitutedimidazole or 2-substitutedbenzimidazole derivatives as carrier ligands. İstanbul Journal of Pharmacy, [Publisher Location], v. 53, n. 3, p. 308-313, 2023.


Chicago: Author-Date Style

Ertuğrul, Emine Merve, and Azime Berna Özçelik and Nebahat Aytuna Çerçi and Leyla Açık and Semra Utku. 2023. “Synthesis, characterization and in vitro cytotoxic activity of platinum(II) oxalato complexes involving 2-substitutedimidazole or 2-substitutedbenzimidazole derivatives as carrier ligands.” İstanbul Journal of Pharmacy 53, no. 3: 308-313. https://doi.org/10.26650/IstanbulJPharm.2023.1266118


Chicago: Humanities Style

Ertuğrul, Emine Merve, and Azime Berna Özçelik and Nebahat Aytuna Çerçi and Leyla Açık and Semra Utku. “Synthesis, characterization and in vitro cytotoxic activity of platinum(II) oxalato complexes involving 2-substitutedimidazole or 2-substitutedbenzimidazole derivatives as carrier ligands.” İstanbul Journal of Pharmacy 53, no. 3 (Apr. 2024): 308-313. https://doi.org/10.26650/IstanbulJPharm.2023.1266118


Harvard: Australian Style

Ertuğrul, EM & Özçelik, AB & Çerçi, NA & Açık, L & Utku, S 2023, 'Synthesis, characterization and in vitro cytotoxic activity of platinum(II) oxalato complexes involving 2-substitutedimidazole or 2-substitutedbenzimidazole derivatives as carrier ligands', İstanbul Journal of Pharmacy, vol. 53, no. 3, pp. 308-313, viewed 28 Apr. 2024, https://doi.org/10.26650/IstanbulJPharm.2023.1266118


Harvard: Author-Date Style

Ertuğrul, E.M. and Özçelik, A.B. and Çerçi, N.A. and Açık, L. and Utku, S. (2023) ‘Synthesis, characterization and in vitro cytotoxic activity of platinum(II) oxalato complexes involving 2-substitutedimidazole or 2-substitutedbenzimidazole derivatives as carrier ligands’, İstanbul Journal of Pharmacy, 53(3), pp. 308-313. https://doi.org/10.26650/IstanbulJPharm.2023.1266118 (28 Apr. 2024).


MLA

Ertuğrul, Emine Merve, and Azime Berna Özçelik and Nebahat Aytuna Çerçi and Leyla Açık and Semra Utku. “Synthesis, characterization and in vitro cytotoxic activity of platinum(II) oxalato complexes involving 2-substitutedimidazole or 2-substitutedbenzimidazole derivatives as carrier ligands.” İstanbul Journal of Pharmacy, vol. 53, no. 3, 2023, pp. 308-313. [Database Container], https://doi.org/10.26650/IstanbulJPharm.2023.1266118


Vancouver

Ertuğrul EM, Özçelik AB, Çerçi NA, Açık L, Utku S. Synthesis, characterization and in vitro cytotoxic activity of platinum(II) oxalato complexes involving 2-substitutedimidazole or 2-substitutedbenzimidazole derivatives as carrier ligands. İstanbul Journal of Pharmacy [Internet]. 28 Apr. 2024 [cited 28 Apr. 2024];53(3):308-313. Available from: https://doi.org/10.26650/IstanbulJPharm.2023.1266118 doi: 10.26650/IstanbulJPharm.2023.1266118


ISNAD

Ertuğrul, EmineMerve - Özçelik, AzimeBerna - Çerçi, NebahatAytuna - Açık, Leyla - Utku, Semra. “Synthesis, characterization and in vitro cytotoxic activity of platinum(II) oxalato complexes involving 2-substitutedimidazole or 2-substitutedbenzimidazole derivatives as carrier ligands”. İstanbul Journal of Pharmacy 53/3 (Apr. 2024): 308-313. https://doi.org/10.26650/IstanbulJPharm.2023.1266118



TIMELINE


Submitted24.03.2023
Accepted12.07.2023
Published Online28.12.2023

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