Original Research


DOI :10.26650/IstanbulJPharm.2020.0017   IUP :10.26650/IstanbulJPharm.2020.0017    Full Text (PDF)

The inhibitory effects of plant extracts, vitamins and amino acids on myeloperoxidase activity

Sevim TunalıFatma Yaşar BoztaşRefiye Yanardağ

Background and Aims: Myeloperoxidase (MPO, EC 1.11.2.2) is a vital antimicrobial enzyme, having a crucial role in host defense. Obstructing the activity of MPO is a possible pharmacological approach for the hindrance and management of a wide array of inflammatory illnesses. Consequently, blocking the activity of MPO is a potential pharmacological strategy for prevention and treatment of a broad range of inflammatory diseases.

Methods: In our study, inhibitory effects of 6 different sulfur containing plant extracts, 16 different vitamins and amino acids were studied for MPO inhibitory activities. The MPO enzyme activity was determined spectrophotometrically according to the method of Wei and Frankel.

Results: Among the aqueous plant extracts, black cabbage extract having IC50=0.92±0.07 mM showed the highest inhibition. Among the vitamins and amino acids studied, the highest MPO enzyme inhibition was exhibited by ascorbic acid with IC50=0.01±0.003 and cysteine with IC50=1.09±0.73 mM.

Conclusion: Based on the outcomes, it was observed that all the examined plant extracts, vitamins and amino acids inhibited MPO enzyme at certain ratios.


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APA

Tunalı, S., Yaşar Boztaş, F., & Yanardağ, R. (2020). The inhibitory effects of plant extracts, vitamins and amino acids on myeloperoxidase activity. İstanbul Journal of Pharmacy, 50(2), 125-130. https://doi.org/10.26650/IstanbulJPharm.2020.0017


AMA

Tunalı S, Yaşar Boztaş F, Yanardağ R. The inhibitory effects of plant extracts, vitamins and amino acids on myeloperoxidase activity. İstanbul Journal of Pharmacy. 2020;50(2):125-130. https://doi.org/10.26650/IstanbulJPharm.2020.0017


ABNT

Tunalı, S.; Yaşar Boztaş, F.; Yanardağ, R. The inhibitory effects of plant extracts, vitamins and amino acids on myeloperoxidase activity. İstanbul Journal of Pharmacy, [Publisher Location], v. 50, n. 2, p. 125-130, 2020.


Chicago: Author-Date Style

Tunalı, Sevim, and Fatma Yaşar Boztaş and Refiye Yanardağ. 2020. “The inhibitory effects of plant extracts, vitamins and amino acids on myeloperoxidase activity.” İstanbul Journal of Pharmacy 50, no. 2: 125-130. https://doi.org/10.26650/IstanbulJPharm.2020.0017


Chicago: Humanities Style

Tunalı, Sevim, and Fatma Yaşar Boztaş and Refiye Yanardağ. The inhibitory effects of plant extracts, vitamins and amino acids on myeloperoxidase activity.” İstanbul Journal of Pharmacy 50, no. 2 (May. 2024): 125-130. https://doi.org/10.26650/IstanbulJPharm.2020.0017


Harvard: Australian Style

Tunalı, S & Yaşar Boztaş, F & Yanardağ, R 2020, 'The inhibitory effects of plant extracts, vitamins and amino acids on myeloperoxidase activity', İstanbul Journal of Pharmacy, vol. 50, no. 2, pp. 125-130, viewed 20 May. 2024, https://doi.org/10.26650/IstanbulJPharm.2020.0017


Harvard: Author-Date Style

Tunalı, S. and Yaşar Boztaş, F. and Yanardağ, R. (2020) ‘The inhibitory effects of plant extracts, vitamins and amino acids on myeloperoxidase activity’, İstanbul Journal of Pharmacy, 50(2), pp. 125-130. https://doi.org/10.26650/IstanbulJPharm.2020.0017 (20 May. 2024).


MLA

Tunalı, Sevim, and Fatma Yaşar Boztaş and Refiye Yanardağ. The inhibitory effects of plant extracts, vitamins and amino acids on myeloperoxidase activity.” İstanbul Journal of Pharmacy, vol. 50, no. 2, 2020, pp. 125-130. [Database Container], https://doi.org/10.26650/IstanbulJPharm.2020.0017


Vancouver

Tunalı S, Yaşar Boztaş F, Yanardağ R. The inhibitory effects of plant extracts, vitamins and amino acids on myeloperoxidase activity. İstanbul Journal of Pharmacy [Internet]. 20 May. 2024 [cited 20 May. 2024];50(2):125-130. Available from: https://doi.org/10.26650/IstanbulJPharm.2020.0017 doi: 10.26650/IstanbulJPharm.2020.0017


ISNAD

Tunalı, Sevim - Yaşar Boztaş, Fatma - Yanardağ, Refiye. The inhibitory effects of plant extracts, vitamins and amino acids on myeloperoxidase activity”. İstanbul Journal of Pharmacy 50/2 (May. 2024): 125-130. https://doi.org/10.26650/IstanbulJPharm.2020.0017



TIMELINE


Submitted05.03.2020
Accepted03.06.2020
Published Online27.08.2020

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