Journal of Advanced Research in Health Sciences

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Research Article


DOI :10.26650/JARHS2025-1582236   IUP :10.26650/JARHS2025-1582236    Full Text (PDF)

A SINGLE CENTRE EXPERIENCE OF LOW C3/C4 LEVELS AND OTHER LABORATORY ASPECTS IN TURKISH CHILDREN WITH IMMUNOGLOBULIN A VASCULITIS

Şeyda Doğantan, Sema Nur Taşkın

Objective: Immunoglobulin A vasculitis (IgAV) is the most prevalent systemic vasculitis in childhood. This intricate immune-mediated vasculitis affects the small blood vessels in several organ systems. Complements 3 and 4 (C3 and C4) are constituents of the complement system; serum C3/ C4 measurements play a

Material and Methods: A total of 124 children—60 IgAV patients and 64 healthy controls—were assessed in this study. The C3 and C4 levels were quantified using a turbidimetric immunoassays method with manufacturer details. The extractable nuclear antigen antibody (ENA) panels were evaluated using the ELISA method. The results were evaluated statistically.

Results: The white blood cell count, neutrophil count, and neutrophil/ lymphocyte ratio were higher in the patient group compared to the control group (p=0.015, p=0.013 and p=0.039, respectively). CRP, ESR, and random urine protein/creatinine ratio (RUPCR) increased in patients than controls (p<0.001, p=0.002 and p<0.001 respectively). There was no difference in the lupus anticoagulant activity and low C3/C4 levels between the groups (p˃0.05).

Conclusion: IgAV, an IgA-mediated systemic small vessel vasculitis, affects many organs. As a result, it is crucial to evaluate the laboratory results in the follow-up of the patient and the possible complications.

Keywords: Immunoglobulin A vasculitis, C3, C4, immunoassay
DOI :10.26650/JARHS2025-1582236   IUP :10.26650/JARHS2025-1582236    Full Text (PDF)

İMMÜNOGLOBULİN A VASKÜLİTLİ TÜRK ÇOCUKLARINDA DÜŞÜK C3/ C4 DÜZEYLERİ VE DİĞER LABORATUVAR ÖZELLİKLERİYLE İLGİLİ TEK MERKEZ DENEYİMİ

Şeyda Doğantan, Sema Nur Taşkın

Amaç: Eskiden Henoch-Schönlein purpurası olarak adlandırılan immünog lobulin A vasküliti (IgAV), çocukluk çağında en sık görülen sistemik vaskülit türüdür. Kompleman 3 ve 4 (C3 ve C4) kompleman sisteminin bileşenleri dir ve bazı bağışıklık hastalıklarıyla ilişkili oldukları bulunmuştur. Bu neden le bu çalışmada IgAV’li çocuklarda düşük C3/C4 düzeylerinin yanı sıra diğer laboratuvar bulgularını değerlendirmeyi amaçladık.

Gereç ve Yöntemler: Bu çalışmada 60 IgAV hastası ve 64 sağlıklı kontrol olmak üzere toplam 124 çocuk değerlendirildi. C3 ve C4 düzeyleri, üretici ayrıntılarıyla birlikte türbidimetrik immünoanaliz yöntemi kullanılarak ölçüldü. Ekstrakte edilebilir nükleer antijen antikor (ENA) panelleri, enzime bağlı immünosorbent analizleri (ELISA) kullanılarak değerlendirildi. Sonuçlar istatistiksel olarak değerlendirildi.

Bulgular: Hasta grubunda lökosit sayısı, nötrofil sayısı ve nötrofil/lenfosit oranı kontrol grubuna göre daha yüksek bulundu (sırasıyla p=0,015, p=0,013 ve p=0,039). Ayrıca hastalarda kontrollere göre CRP, ESR ve rastgele idrar protein/kreatinin oranı (RUPCR) artmış bulundu (sırasıyla p<0,001, p=0,002 ve p<0,001). Düşük C3/C4 seviyeleri ve lupus antikoagülan aktivitesi açısından gruplar arasında anlamlı fark bulunamadı (p˃0,05).

Sonuç: IgA aracılı sistemik küçük damar vasküliti olan IgAV, öncelikle böbrekleri, eklemleri, gastrointestinal sistemi ve cildi etkilemektedir. Sonuç olarak, potansiyel hasta durumlarını izlerken laboratuvar sonuçlarının değerlendirilmesi çok önemlidir.

Keywords: İmmünoglobulin A vasküliti, C3, C4, immünolojik test

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APA

Doğantan, Ş., & Taşkın, S.N. (2025). A SINGLE CENTRE EXPERIENCE OF LOW C3/C4 LEVELS AND OTHER LABORATORY ASPECTS IN TURKISH CHILDREN WITH IMMUNOGLOBULIN A VASCULITIS. Journal of Advanced Research in Health Sciences, 8(1), 47-52. https://doi.org/10.26650/JARHS2025-1582236


AMA

Doğantan Ş, Taşkın S N. A SINGLE CENTRE EXPERIENCE OF LOW C3/C4 LEVELS AND OTHER LABORATORY ASPECTS IN TURKISH CHILDREN WITH IMMUNOGLOBULIN A VASCULITIS. Journal of Advanced Research in Health Sciences. 2025;8(1):47-52. https://doi.org/10.26650/JARHS2025-1582236


ABNT

Doğantan, Ş.; Taşkın, S.N. A SINGLE CENTRE EXPERIENCE OF LOW C3/C4 LEVELS AND OTHER LABORATORY ASPECTS IN TURKISH CHILDREN WITH IMMUNOGLOBULIN A VASCULITIS. Journal of Advanced Research in Health Sciences, [Publisher Location], v. 8, n. 1, p. 47-52, 2025.


Chicago: Author-Date Style

Doğantan, Şeyda, and Sema Nur Taşkın. 2025. “A SINGLE CENTRE EXPERIENCE OF LOW C3/C4 LEVELS AND OTHER LABORATORY ASPECTS IN TURKISH CHILDREN WITH IMMUNOGLOBULIN A VASCULITIS.” Journal of Advanced Research in Health Sciences 8, no. 1: 47-52. https://doi.org/10.26650/JARHS2025-1582236


Chicago: Humanities Style

Doğantan, Şeyda, and Sema Nur Taşkın. “A SINGLE CENTRE EXPERIENCE OF LOW C3/C4 LEVELS AND OTHER LABORATORY ASPECTS IN TURKISH CHILDREN WITH IMMUNOGLOBULIN A VASCULITIS.” Journal of Advanced Research in Health Sciences 8, no. 1 (Mar. 2025): 47-52. https://doi.org/10.26650/JARHS2025-1582236


Harvard: Australian Style

Doğantan, Ş & Taşkın, SN 2025, 'A SINGLE CENTRE EXPERIENCE OF LOW C3/C4 LEVELS AND OTHER LABORATORY ASPECTS IN TURKISH CHILDREN WITH IMMUNOGLOBULIN A VASCULITIS', Journal of Advanced Research in Health Sciences, vol. 8, no. 1, pp. 47-52, viewed 12 Mar. 2025, https://doi.org/10.26650/JARHS2025-1582236


Harvard: Author-Date Style

Doğantan, Ş. and Taşkın, S.N. (2025) ‘A SINGLE CENTRE EXPERIENCE OF LOW C3/C4 LEVELS AND OTHER LABORATORY ASPECTS IN TURKISH CHILDREN WITH IMMUNOGLOBULIN A VASCULITIS’, Journal of Advanced Research in Health Sciences, 8(1), pp. 47-52. https://doi.org/10.26650/JARHS2025-1582236 (12 Mar. 2025).


MLA

Doğantan, Şeyda, and Sema Nur Taşkın. “A SINGLE CENTRE EXPERIENCE OF LOW C3/C4 LEVELS AND OTHER LABORATORY ASPECTS IN TURKISH CHILDREN WITH IMMUNOGLOBULIN A VASCULITIS.” Journal of Advanced Research in Health Sciences, vol. 8, no. 1, 2025, pp. 47-52. [Database Container], https://doi.org/10.26650/JARHS2025-1582236


Vancouver

Doğantan Ş, Taşkın SN. A SINGLE CENTRE EXPERIENCE OF LOW C3/C4 LEVELS AND OTHER LABORATORY ASPECTS IN TURKISH CHILDREN WITH IMMUNOGLOBULIN A VASCULITIS. Journal of Advanced Research in Health Sciences [Internet]. 12 Mar. 2025 [cited 12 Mar. 2025];8(1):47-52. Available from: https://doi.org/10.26650/JARHS2025-1582236 doi: 10.26650/JARHS2025-1582236


ISNAD

Doğantan, Şeyda - Taşkın, SemaNur. “A SINGLE CENTRE EXPERIENCE OF LOW C3/C4 LEVELS AND OTHER LABORATORY ASPECTS IN TURKISH CHILDREN WITH IMMUNOGLOBULIN A VASCULITIS”. Journal of Advanced Research in Health Sciences 8/1 (Mar. 2025): 47-52. https://doi.org/10.26650/JARHS2025-1582236



TIMELINE


Submitted09.11.2024
Accepted05.01.2025
Published Online29.01.2025

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