Journal of Advanced Research in Health Sciences

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DOI :10.26650/JARHS2020-732729   IUP :10.26650/JARHS2020-732729    Full Text (PDF)

Cumulative Antibiogram Results of Bacteria Isolated from Blood Cultures in a University Hospital

Lütfiye Öksüz, Zerrin Aktaş

Objective: This study investigated the cumulative antimicrobial data of bacteria isolated from blood cultures and aimed to contributing to clinicians' empirical treatment selection. Material and Methods: The study included blood cultures studied between January 2018 and May 2019. Only bacteria species that have 30 or more isolates were evaluated. Only the first isolate for each patient was included in the study. The cumulative antibiotic susceptibility limit for empirical treatment was >90%. Results: The most appropriate antibiotics for empirical treatment in methicillin-resistant Staphylococcus aureus isolates were vancomycin, teicoplanin and linezolid. Co-trimoxazole and tetracycline options in addition to vancomycin, teicoplanin and linezolid were suitable for therapy in methicillin-sensitive S. aureus isolates. Ampicillin and high level-gentamicin alongside vancomycin, teicoplanin and linezolid were found to be appropriate for empirical treatment in Enterococcus faecalis isolates, while linezolid was the only option in Enterococcus faecium isolates. Although cephalosporins, aminoglycosides and piperacillin tazobactam as well as carbapenems were suitable for empiric therapy in the ESBL-negative group, only carbapenems were found suitable for empirical treatment in Escherichia coli isolates producing extended-spectrum betalactamase. There was no empirical treatment option for ESBL positive Klebsiella pneumoniae. Carbapenem resistance of these bacteria was found to reach 50%. Third and 4th generation cephalosporins, carbapenems, aminoglycosides and ciprofloxacin were appropriate for empirical treatment in ESBL negative K. pneumoniae isolates. Conclusion: Due to the high resistance rates in our study, regular surveillance monitoring should be performed. Studies are needed to test the efficacy of antibiotic combinations for multi-resistant organisms, including carbapenem-resistant bacteria.

Keywords: Blood culture, cumulative antibiogram, antimicrobial resistance
DOI :10.26650/JARHS2020-732729   IUP :10.26650/JARHS2020-732729    Full Text (PDF)

Bir Üniversite Hastanesinde Kan Kültürlerinden İzole Edilen Bakterilerin Kümülatif Antibiyogram Sonuçları

Lütfiye Öksüz, Zerrin Aktaş

Amaç: Bu çalışmada, kan kültürlerinden izole edilen bakterilerin kümülatif antimikrobiyal verileri araştırılmış ve klinisyenlerin ampirik tedavi seçimine katkıda bulunulması amaçlanmıştır. Gereç ve Yöntem: Çalışmaya Ocak 2018-Mayıs2019 arasında çalışılan kan kültürleri dahil edilmiştir. Sadece izolat sayısı >30 olan bakteriler değerlendirilmiştir. Her hasta için ilk izolat çalışmaya dahil edilmiştir. Ampirik tedavi için kümülatif antibiyotik duyarlılık sınırı >%90 olarak kabul edilmiştir. Bulgular: Metisiline dirençli Staphylococcus aureus izolatlarında ampirik tedavi için en uygun antibiyotiklerin vankomisin, teikoplanin ve linezolid olduğu; metisiline duyarlı S. aureus izolatlarında bu antibiyotiklere ek olarak kotrimoksazol ve tetrasiklin seçeneklerinin olduğu bulunmuştur. Enterococcus faecalis izolatlarında vankomisin, teikoplanin ve linezolide ek olarak ampisilin ve yüksek düzey gentamisinin ampirik tedaviye uygun olduğu bulunurken, Enterococcus faecium izolatlarında tek ampirik tedavi seçeneğinin linezolid olduğu belirlenmiştir. Genişlemiş spektrumlu beta laktamaz oluşturmayan grupta karbapenemlere ek olarak 3. ve 4. kuşak sefalosporinler, aminoglikozidler ve piperasilin+tazobaktam ampirik tedavi için uygun olmasına rağmen, GSBL oluşturan Escherichia coli izolatlarında sadece karbapenem grubu antibiyotikler ampirik tedavi için uygun bulunmuştur. GSBL pozitif Klebsiella pneumoniae için ampirik tedavi seçeneği olmadığı ve bu grupta karbapenem direncinin % 50’ye ulaştığı bulunmuştur. GSBL negatif izolatlarda 3. ve 4. kuşak sefalosporinler, karbapenemler, aminoglikozidler ve siprofloksasinin ampirik tedavi için uygun olduğu bulunmuştur. Sonuç: Çalışmamızda elde edilen yüksek direnç oranları nedeniyle, düzenli sürveyans takibinin yapılması gerekmektedir. Karbapenemleri de kapsayan çoğul dirençli mikroorganizmalar için antibiyotik kombinasyonlarının etkinliğini test eden çalışmalara ihtiyaç vardır. 

Keywords: Kan kültürü, kümülatif antibiyogram, antimikrobiyal direnç

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APA

Öksüz, L., & Aktaş, Z. (2020). Cumulative Antibiogram Results of Bacteria Isolated from Blood Cultures in a University Hospital. Journal of Advanced Research in Health Sciences, 3(2), 35-44. https://doi.org/10.26650/JARHS2020-732729


AMA

Öksüz L, Aktaş Z. Cumulative Antibiogram Results of Bacteria Isolated from Blood Cultures in a University Hospital. Journal of Advanced Research in Health Sciences. 2020;3(2):35-44. https://doi.org/10.26650/JARHS2020-732729


ABNT

Öksüz, L.; Aktaş, Z. Cumulative Antibiogram Results of Bacteria Isolated from Blood Cultures in a University Hospital. Journal of Advanced Research in Health Sciences, [Publisher Location], v. 3, n. 2, p. 35-44, 2020.


Chicago: Author-Date Style

Öksüz, Lütfiye, and Zerrin Aktaş. 2020. “Cumulative Antibiogram Results of Bacteria Isolated from Blood Cultures in a University Hospital.” Journal of Advanced Research in Health Sciences 3, no. 2: 35-44. https://doi.org/10.26650/JARHS2020-732729


Chicago: Humanities Style

Öksüz, Lütfiye, and Zerrin Aktaş. “Cumulative Antibiogram Results of Bacteria Isolated from Blood Cultures in a University Hospital.” Journal of Advanced Research in Health Sciences 3, no. 2 (May. 2024): 35-44. https://doi.org/10.26650/JARHS2020-732729


Harvard: Australian Style

Öksüz, L & Aktaş, Z 2020, 'Cumulative Antibiogram Results of Bacteria Isolated from Blood Cultures in a University Hospital', Journal of Advanced Research in Health Sciences, vol. 3, no. 2, pp. 35-44, viewed 9 May. 2024, https://doi.org/10.26650/JARHS2020-732729


Harvard: Author-Date Style

Öksüz, L. and Aktaş, Z. (2020) ‘Cumulative Antibiogram Results of Bacteria Isolated from Blood Cultures in a University Hospital’, Journal of Advanced Research in Health Sciences, 3(2), pp. 35-44. https://doi.org/10.26650/JARHS2020-732729 (9 May. 2024).


MLA

Öksüz, Lütfiye, and Zerrin Aktaş. “Cumulative Antibiogram Results of Bacteria Isolated from Blood Cultures in a University Hospital.” Journal of Advanced Research in Health Sciences, vol. 3, no. 2, 2020, pp. 35-44. [Database Container], https://doi.org/10.26650/JARHS2020-732729


Vancouver

Öksüz L, Aktaş Z. Cumulative Antibiogram Results of Bacteria Isolated from Blood Cultures in a University Hospital. Journal of Advanced Research in Health Sciences [Internet]. 9 May. 2024 [cited 9 May. 2024];3(2):35-44. Available from: https://doi.org/10.26650/JARHS2020-732729 doi: 10.26650/JARHS2020-732729


ISNAD

Öksüz, Lütfiye - Aktaş, Zerrin. “Cumulative Antibiogram Results of Bacteria Isolated from Blood Cultures in a University Hospital”. Journal of Advanced Research in Health Sciences 3/2 (May. 2024): 35-44. https://doi.org/10.26650/JARHS2020-732729



TIMELINE


Submitted05.05.2020
Accepted16.06.2020
Published Online10.07.2020

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