Research Article


DOI :10.26650/JARHS2024-1347787   IUP :10.26650/JARHS2024-1347787    Full Text (PDF)

PROBIOTICS’ EFFECT ON NUTRITIONAL STATUS, APPETITE HORMONES, AND INFLAMMATION IN PRE-OBESE WOMEN

İzzet ÜlkerHilal YıldıranMüjde Yaşım Aktürk

Objective: Obesity is one of the most common health problems in the world. The following methods are currently used to treat obesity: medical nutrition therapy, behavioral therapy, medical treatment, and surgical therapy. Discussions are still ongoing regarding whether changing the plasma levels of the hormones that regulate satiety and appetite can be used as a new add-on therapy to pre-existing obesity treatments to decrease food consumption. One possibility for changing the levels of the hormones that control hunger and satiety involves the use of probiotics. This study has been planned and conducted to examine the effects of probiotics on appetite, inflammation, and nutritional status in overweight individuals.

Materials and Methods: The study includes 35 overweight females aged 19-30 years old to who a questionnaire form had been applied prior to the study. Probiotics were given to these individuals for 8 weeks. Food consumption records and anthropometric measurements were taken and a body composition analysis conducted three times during the study. Inflammatory markers such as CRP, TNF-α, and IL-6 and the hormone analyses (i.e., leptin, adiponectin, cholecystokinin, ghrelin, GLP-1, and PYY) were evaluated at the beginning and end of the study using the ELISA method.

Results: The women were asked about their physical activity status, and their appetite hormones and inflammatory markers were analyzed both at the beginning and end of the study. When taken together, the study found the individuals’ anthropometric measurements, inflammatory markers, and hunger hormone levels to have decreased significantly and their satiety hormone levels to have increased significantly after the use of probiotics (p<0.05). However, no significant changes occurred regarding their energy, macronutrients, fiber intake, or physical activity levels (p>0.05). 

Conclusion: The study clearly shows an appropriate probiotic strain to be able to significantly affect anthropometric measurements, inflammatory markers, and appetite hormones in overweight individuals without any other intervention.

DOI :10.26650/JARHS2024-1347787   IUP :10.26650/JARHS2024-1347787    Full Text (PDF)

PROBİYOTİKLERİN PRE-OBEZ KADINLARDA BESLENME DURUMU, AÇLIKTOKLUK HORMONLARI VE İNFLAMASYON DURUMU ÜZERİNE ETKİSİ

İzzet ÜlkerHilal YıldıranMüjde Yaşım Aktürk

Amaç: Obezite dünyadaki en yaygın sağlık sorunlarından birisidir. Obezite tedavisinde güncel yöntemler; tıbbi beslenme tedavisi, davranış terapisi, tıbbi tedavi ve cerrahi tedavidir. Mevcut obezite tedavilerine yeni bir ek tedavi olarak açlık tokluk hormonlarının plazma düzeylerinin değiştirilmesinin besin tüketimini azaltıp azaltmayacağı halen tartışılmaktadır. Açlığı ve tokluğu kontrol eden hormonların düzeylerini değiştirme yöntemlerinden birisi probiyotik kullanımıdır. Bu çalışma hafif şişman bireylerde probiyotiklerin iştah, inflamasyon ve beslenme durumu üzerindeki etkilerini incelemek amacıyla planlanmış ve yürütülmüştür.

Gereç ve Yöntem: Bu çalışmaya yaşları 19-30 arasında değişen 35 hafif şişman kadın dahil edilmiştir ve çalışma öncesinde anket formu uygulanmıştır. Probiyotikler katılımcılara 8 hafta boyunca verilmiştir. Çalışma sırasında 3 kez besin tüketim kayıtları, antropometrik ölçümler ve vücut kompozisyonu analizi yapılmıştır. CRP, TNF-α ve IL-6 gibi inflamatuar belirteçler ve hormon analizleri (Leptin, Adiponektin, Kolesistokinin, Ghrelin, GLP-1, PYY) ELISA yöntemiyle çalışmanın başlangıcında ve sonunda değerlendirilmiştir.

Bulgular: Çalışmanın başında ve sonunda fiziksel aktivite durumu sorgulanmış olup, açlık tokluk hormonları ve inflamatuar belirteçler değerlendirilmiştir. Çalışmanın sonunda başlangıç durumuna göre antropometrik ölçümlerde, inflamatuar belirteçlerde ve açlık hormon düzeylerinin önemli ölçüde azaldığını ancak probiyotik kullanımı sonrasında tokluk hormonu düzeylerinin istatistiksel olarak anlamlı arttığını tespit edilmiştir (p<0,05). Ancak enerji, makrobesin, lif alımı ve fiziksel aktivite düzeyinde istatistiksel olarak fark olmadığı tespit edilmiştir (p>0,05).

Sonuç: Çalışmamız, uygun probiyotik suşunun kilolu bireylerde başka herhangi bir müdahaleye gerek kalmadan antropometrik ölçümleri, inflamatuar belirteçleri ve iştah hormonlarını önemli ölçüde etkileyebileceğini açıkça göstermektedir.


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APA

Ülker, İ., Yıldıran, H., & Yaşım Aktürk, M. (2024). PROBIOTICS’ EFFECT ON NUTRITIONAL STATUS, APPETITE HORMONES, AND INFLAMMATION IN PRE-OBESE WOMEN. Journal of Advanced Research in Health Sciences, 7(2), 73-80. https://doi.org/10.26650/JARHS2024-1347787


AMA

Ülker İ, Yıldıran H, Yaşım Aktürk M. PROBIOTICS’ EFFECT ON NUTRITIONAL STATUS, APPETITE HORMONES, AND INFLAMMATION IN PRE-OBESE WOMEN. Journal of Advanced Research in Health Sciences. 2024;7(2):73-80. https://doi.org/10.26650/JARHS2024-1347787


ABNT

Ülker, İ.; Yıldıran, H.; Yaşım Aktürk, M. PROBIOTICS’ EFFECT ON NUTRITIONAL STATUS, APPETITE HORMONES, AND INFLAMMATION IN PRE-OBESE WOMEN. Journal of Advanced Research in Health Sciences, [Publisher Location], v. 7, n. 2, p. 73-80, 2024.


Chicago: Author-Date Style

Ülker, İzzet, and Hilal Yıldıran and Müjde Yaşım Aktürk. 2024. “PROBIOTICS’ EFFECT ON NUTRITIONAL STATUS, APPETITE HORMONES, AND INFLAMMATION IN PRE-OBESE WOMEN.” Journal of Advanced Research in Health Sciences 7, no. 2: 73-80. https://doi.org/10.26650/JARHS2024-1347787


Chicago: Humanities Style

Ülker, İzzet, and Hilal Yıldıran and Müjde Yaşım Aktürk. PROBIOTICS’ EFFECT ON NUTRITIONAL STATUS, APPETITE HORMONES, AND INFLAMMATION IN PRE-OBESE WOMEN.” Journal of Advanced Research in Health Sciences 7, no. 2 (Oct. 2024): 73-80. https://doi.org/10.26650/JARHS2024-1347787


Harvard: Australian Style

Ülker, İ & Yıldıran, H & Yaşım Aktürk, M 2024, 'PROBIOTICS’ EFFECT ON NUTRITIONAL STATUS, APPETITE HORMONES, AND INFLAMMATION IN PRE-OBESE WOMEN', Journal of Advanced Research in Health Sciences, vol. 7, no. 2, pp. 73-80, viewed 18 Oct. 2024, https://doi.org/10.26650/JARHS2024-1347787


Harvard: Author-Date Style

Ülker, İ. and Yıldıran, H. and Yaşım Aktürk, M. (2024) ‘PROBIOTICS’ EFFECT ON NUTRITIONAL STATUS, APPETITE HORMONES, AND INFLAMMATION IN PRE-OBESE WOMEN’, Journal of Advanced Research in Health Sciences, 7(2), pp. 73-80. https://doi.org/10.26650/JARHS2024-1347787 (18 Oct. 2024).


MLA

Ülker, İzzet, and Hilal Yıldıran and Müjde Yaşım Aktürk. PROBIOTICS’ EFFECT ON NUTRITIONAL STATUS, APPETITE HORMONES, AND INFLAMMATION IN PRE-OBESE WOMEN.” Journal of Advanced Research in Health Sciences, vol. 7, no. 2, 2024, pp. 73-80. [Database Container], https://doi.org/10.26650/JARHS2024-1347787


Vancouver

Ülker İ, Yıldıran H, Yaşım Aktürk M. PROBIOTICS’ EFFECT ON NUTRITIONAL STATUS, APPETITE HORMONES, AND INFLAMMATION IN PRE-OBESE WOMEN. Journal of Advanced Research in Health Sciences [Internet]. 18 Oct. 2024 [cited 18 Oct. 2024];7(2):73-80. Available from: https://doi.org/10.26650/JARHS2024-1347787 doi: 10.26650/JARHS2024-1347787


ISNAD

Ülker, İzzet - Yıldıran, Hilal - Yaşım Aktürk, Müjde. PROBIOTICS’ EFFECT ON NUTRITIONAL STATUS, APPETITE HORMONES, AND INFLAMMATION IN PRE-OBESE WOMEN”. Journal of Advanced Research in Health Sciences 7/2 (Oct. 2024): 73-80. https://doi.org/10.26650/JARHS2024-1347787



TIMELINE


Submitted22.08.2023
Accepted09.11.2023
Published Online22.05.2024

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