Journal of Advanced Research in Health Sciences

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Research Article


DOI :10.26650/JARHS2020-650905   IUP :10.26650/JARHS2020-650905    Full Text (PDF)

Two years experience of a multidisciplinary approach for pediatric thrombosis in a tertiary referral center

Rumeysa Tuna, Mustafa Bilici, Osman Kipoğlu, Orhan Coşkun, Zuhal Bayramoğlu, Süheyla Ocak, Deniz Tuğcu, Serap Karaman, Ayşegül Ünüvar, Serra Sencer, Nur Aydınlı, Zerrin Önal, Zeynep Nagehan Yürük Yıldırım, Kemal Nişli, Rukiye Eker Ömeroğlu, Aygün Dindar, Demet Demirkol, Elmas Zeynep İnce, Meliha Mine Çalışkan, Zeynep Karakaş

Pediatric thrombosis has unique characteristics due to its epidemiology, pathophysiology and treatment considerations. Children diagnosed with thrombosis should be evaluated by a multidisciplinary team at the level of diagnosis, treatment, and follow-up. Here we present our 2 years experience of pediatric thrombosis patients with a multidisciplinary thrombosis council management. We retrospectively reviewed case presentations and recommendations of monthly thrombosis council for 61 children (95 admissions) between November 2017 and August 2019. The male/female ratio was 1.54 and children and adolescents were the majority of evaluated 61 patients. Based on patients' clinical and radiological status, treatment and prophylaxis periods were determined. Cerebral arterial and sinovenous thrombosis were more common in our pediatric thrombosis council cases. Acquired risk factors for thrombosis were more common than congenital thrombophilia. Infection and elevated Factor VIII were commonest, respectively. Thirty-nine patients (64%) received primary or secondary prophylaxis with vitamin K antagonists, aspirin or LMVH for different periods. Further studies on treatment and prophylaxis management are needed for the improvement of evidence-based guidelines in pediatric thrombosis. Multidisciplinary councils may improve patient care for pediatric patients with complicated thrombosis. 

Keywords: Pediatric thrombosis, treatment, prophylaxis, multidisciplinary management
DOI :10.26650/JARHS2020-650905   IUP :10.26650/JARHS2020-650905    Full Text (PDF)

Pediatrik tromboza multidisipliner yaklaşım, üçüncü basamak referans merkezin 2 yıllık deneyimi

Rumeysa Tuna, Mustafa Bilici, Osman Kipoğlu, Orhan Coşkun, Zuhal Bayramoğlu, Süheyla Ocak, Deniz Tuğcu, Serap Karaman, Ayşegül Ünüvar, Serra Sencer, Nur Aydınlı, Zerrin Önal, Zeynep Nagehan Yürük Yıldırım, Kemal Nişli, Rukiye Eker Ömeroğlu, Aygün Dindar, Demet Demirkol, Elmas Zeynep İnce, Meliha Mine Çalışkan, Zeynep Karakaş

Pediatrik tromboz epidemiyolojisi, patofizyolojisi ve tedavi öncelikleri nedeniyle erişkin tromboz yönetiminden çok farklı özelliklere sahiptir. Tromboz teşhisi konan çocuklar, multidisipliner bir ekip tarafından tanı, tedavi ve takip süresince değerlendirilmelidir. Burada pediatrik tromboz hastalarımızın yönetildiği 2 yıllık multidisipliner tromboz konseyi deneyimimizi sunuyoruz. Kasım 2017-Ağustos 2019 tarihleri arasında 61 çocuk (95 başvuru) için tromboz konseyi olgu sunumlarını ve konsey sonuçlarını geriye dönük olarak inceledik. Değerlendirilen hastalarda erkek/kadın oranı 1,54 saptandı, çocuklar ve adolesanlar çoğunluktaydı. Hastaların klinik ve radyolojik durumlarına göre tedavi ve profilaksi süreleri belirlendi. Olgularımız içinde serebral arteriyel ve sinovenöz tromboz olguları daha fazla idi. Kazanılmış risk faktörleri, kalıtsal olanlardan daha fazla olup, infeksiyon ve Faktör VIII yüksekliği sık idi. Otuz dokuz hastaya (%64) farklı süreler boyunca K vitamini antagonistleri, aspirin veya LMVH ile primer veya sekonder profilaksi uygulandı. Pediatrik trombozda kanıta dayalı kılavuzların iyileştirilmesi için tedavi ve profilaksi yönetimi üzerine daha fazla çalışmaya ihtiyaç vardır. Multidisipliner tromboz konseyi komplike pediatrik trombozlu çocuk hastalarda hasta bakımını iyileştirebilir. 

Keywords: Pediatrik tromboz, tedavi, proflaksi, multidisipliner yönetim

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APA

Tuna, R., Bilici, M., Kipoğlu, O., Coşkun, O., Bayramoğlu, Z., Ocak, S., Tuğcu, D., Karaman, S., Ünüvar, A., Sencer, S., Aydınlı, N., Önal, Z., Yürük Yıldırım, Z.N., Nişli, K., Eker Ömeroğlu, R., Dindar, A., Demirkol, D., İnce, E.Z., Çalışkan, M.M., & Karakaş, Z. (2020). Two years experience of a multidisciplinary approach for pediatric thrombosis in a tertiary referral center. Journal of Advanced Research in Health Sciences, 3(1), 1-4. https://doi.org/10.26650/JARHS2020-650905


AMA

Tuna R, Bilici M, Kipoğlu O, Coşkun O, Bayramoğlu Z, Ocak S, Tuğcu D, Karaman S, Ünüvar A, Sencer S, Aydınlı N, Önal Z, Yürük Yıldırım Z N, Nişli K, Eker Ömeroğlu R, Dindar A, Demirkol D, İnce E Z, Çalışkan M M, Karakaş Z. Two years experience of a multidisciplinary approach for pediatric thrombosis in a tertiary referral center. Journal of Advanced Research in Health Sciences. 2020;3(1):1-4. https://doi.org/10.26650/JARHS2020-650905


ABNT

Tuna, R.; Bilici, M.; Kipoğlu, O.; Coşkun, O.; Bayramoğlu, Z.; Ocak, S.; Tuğcu, D.; Karaman, S.; Ünüvar, A.; Sencer, S.; Aydınlı, N.; Önal, Z.; Yürük Yıldırım, Z.N.; Nişli, K.; Eker Ömeroğlu, R.; Dindar, A.; Demirkol, D.; İnce, E.Z.; Çalışkan, M.M.; Karakaş, Z. Two years experience of a multidisciplinary approach for pediatric thrombosis in a tertiary referral center. Journal of Advanced Research in Health Sciences, [Publisher Location], v. 3, n. 1, p. 1-4, 2020.


Chicago: Author-Date Style

Tuna, Rumeysa, and Mustafa Bilici and Osman Kipoğlu and Orhan Coşkun and Zuhal Bayramoğlu and Süheyla Ocak and Deniz Tuğcu and Serap Karaman and Ayşegül Ünüvar and Serra Sencer and Nur Aydınlı and Zerrin Önal and Zeynep Nagehan Yürük Yıldırım and Kemal Nişli and Rukiye Eker Ömeroğlu and Aygün Dindar and Demet Demirkol and Elmas Zeynep İnce and Meliha Mine Çalışkan and Zeynep Karakaş. 2020. “Two years experience of a multidisciplinary approach for pediatric thrombosis in a tertiary referral center.” Journal of Advanced Research in Health Sciences 3, no. 1: 1-4. https://doi.org/10.26650/JARHS2020-650905


Chicago: Humanities Style

Tuna, Rumeysa, and Mustafa Bilici and Osman Kipoğlu and Orhan Coşkun and Zuhal Bayramoğlu and Süheyla Ocak and Deniz Tuğcu and Serap Karaman and Ayşegül Ünüvar and Serra Sencer and Nur Aydınlı and Zerrin Önal and Zeynep Nagehan Yürük Yıldırım and Kemal Nişli and Rukiye Eker Ömeroğlu and Aygün Dindar and Demet Demirkol and Elmas Zeynep İnce and Meliha Mine Çalışkan and Zeynep Karakaş. “Two years experience of a multidisciplinary approach for pediatric thrombosis in a tertiary referral center.” Journal of Advanced Research in Health Sciences 3, no. 1 (Apr. 2024): 1-4. https://doi.org/10.26650/JARHS2020-650905


Harvard: Australian Style

Tuna, R & Bilici, M & Kipoğlu, O & Coşkun, O & Bayramoğlu, Z & Ocak, S & Tuğcu, D & Karaman, S & Ünüvar, A & Sencer, S & Aydınlı, N & Önal, Z & Yürük Yıldırım, ZN & Nişli, K & Eker Ömeroğlu, R & Dindar, A & Demirkol, D & İnce, EZ & Çalışkan, MM & Karakaş, Z 2020, 'Two years experience of a multidisciplinary approach for pediatric thrombosis in a tertiary referral center', Journal of Advanced Research in Health Sciences, vol. 3, no. 1, pp. 1-4, viewed 25 Apr. 2024, https://doi.org/10.26650/JARHS2020-650905


Harvard: Author-Date Style

Tuna, R. and Bilici, M. and Kipoğlu, O. and Coşkun, O. and Bayramoğlu, Z. and Ocak, S. and Tuğcu, D. and Karaman, S. and Ünüvar, A. and Sencer, S. and Aydınlı, N. and Önal, Z. and Yürük Yıldırım, Z.N. and Nişli, K. and Eker Ömeroğlu, R. and Dindar, A. and Demirkol, D. and İnce, E.Z. and Çalışkan, M.M. and Karakaş, Z. (2020) ‘Two years experience of a multidisciplinary approach for pediatric thrombosis in a tertiary referral center’, Journal of Advanced Research in Health Sciences, 3(1), pp. 1-4. https://doi.org/10.26650/JARHS2020-650905 (25 Apr. 2024).


MLA

Tuna, Rumeysa, and Mustafa Bilici and Osman Kipoğlu and Orhan Coşkun and Zuhal Bayramoğlu and Süheyla Ocak and Deniz Tuğcu and Serap Karaman and Ayşegül Ünüvar and Serra Sencer and Nur Aydınlı and Zerrin Önal and Zeynep Nagehan Yürük Yıldırım and Kemal Nişli and Rukiye Eker Ömeroğlu and Aygün Dindar and Demet Demirkol and Elmas Zeynep İnce and Meliha Mine Çalışkan and Zeynep Karakaş. “Two years experience of a multidisciplinary approach for pediatric thrombosis in a tertiary referral center.” Journal of Advanced Research in Health Sciences, vol. 3, no. 1, 2020, pp. 1-4. [Database Container], https://doi.org/10.26650/JARHS2020-650905


Vancouver

Tuna R, Bilici M, Kipoğlu O, Coşkun O, Bayramoğlu Z, Ocak S, Tuğcu D, Karaman S, Ünüvar A, Sencer S, Aydınlı N, Önal Z, Yürük Yıldırım ZN, Nişli K, Eker Ömeroğlu R, Dindar A, Demirkol D, İnce EZ, Çalışkan MM, Karakaş Z. Two years experience of a multidisciplinary approach for pediatric thrombosis in a tertiary referral center. Journal of Advanced Research in Health Sciences [Internet]. 25 Apr. 2024 [cited 25 Apr. 2024];3(1):1-4. Available from: https://doi.org/10.26650/JARHS2020-650905 doi: 10.26650/JARHS2020-650905


ISNAD

Tuna, Rumeysa - Bilici, Mustafa - Kipoğlu, Osman - Coşkun, Orhan - Bayramoğlu, Zuhal - Ocak, Süheyla - Tuğcu, Deniz - Karaman, Serap - Ünüvar, Ayşegül - Sencer, Serra - Aydınlı, Nur - Önal, Zerrin - Yürük Yıldırım, ZeynepNagehan - Nişli, Kemal - Eker Ömeroğlu, Rukiye - Dindar, Aygün - Demirkol, Demet - İnce, ElmasZeynep - Çalışkan, MelihaMine - Karakaş, Zeynep. “Two years experience of a multidisciplinary approach for pediatric thrombosis in a tertiary referral center”. Journal of Advanced Research in Health Sciences 3/1 (Apr. 2024): 1-4. https://doi.org/10.26650/JARHS2020-650905



TIMELINE


Submitted25.11.2019
Accepted02.12.2019
Published Online26.02.2020

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