Journal of Child

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Case Report


DOI :10.26650/jchild.2021.755569   IUP :10.26650/jchild.2021.755569    Full Text (PDF)

A Rare Adverse Effect of Cetirizine in a 7- Month-Old Infant: Dystonic Reaction

Ayşe Süleyman, Esra Özek Yücel, Zeynep Hızlı Demirkale, Sevgi Sipahi Çimen, Ayşe Kılıç, Cevdet Özdemir, Nermin Güler, Zeynep Altınel

Cetirizine is a selective H1 histamine receptor antagonist derived from piperazine. Piperazine is a cyclic moiety molecule located in the structure of many drugs, including anxiolytics, antidepressants, and antipsychotics. Drug-induced dystonia is reported mostly due to antipsychotic and antiemetic drugs. It occurs due to the disruption of dopamine and acetylcholine balance in favor of acetylcholine. Although cetirizine is a relatively safe drug, it has rarely been reported to cause a dystonic reaction. To the best of our knowledge, there is no reported case of dystonia due to cetirizine in infancy. Here, we present a 7-month-old patient who developed a dystonic reaction after cetirizine administration.

Keywords: Acute dystonia, cetirizine, infant
DOI :10.26650/jchild.2021.755569   IUP :10.26650/jchild.2021.755569    Full Text (PDF)

Yedi Aylık Bebekte Setirizin’in Nadir Bir Yan Etkisi: Distonik Reaksiyon

Ayşe Süleyman, Esra Özek Yücel, Zeynep Hızlı Demirkale, Sevgi Sipahi Çimen, Ayşe Kılıç, Cevdet Özdemir, Nermin Güler, Zeynep Altınel

Setirizin, piperazinden türetilen seçici bir H1 histamin reseptör antagonistidir. Piperazin, anksiyolitikler, antidepresanlar ve antipsikotikler dahil olmak üzere birçok ilacın yapısında yer alan siklik bir moleküldür. İlaca bağlı distoni, çoğunlukla antipsikotik ve antiemetik ilaçlara bağlı olarak bildirilmektedir. Dopamin ve asetilkolin dengesinin asetilkolin lehine bozulması sonucu oluşur. Setirizin nispeten güvenli bir ilaç olmasına rağmen, nadiren distonik reaksiyona neden olduğu bildirilmiştir. Şimdiye kadar süt çocukluğu döneminde setirizine bağlı olarak bildirilmiş bir distoni vakası yoktur. Burada setirizin uygulaması sonrası distonik reaksiyon gelişen 7 aylık bir hasta sunulmuştur.

Keywords: Akut distoni, setirizin, sütçocuğu

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APA

Süleyman, A., Özek Yücel, E., Hızlı Demirkale, Z., Sipahi Çimen, S., Kılıç, A., Özdemir, C., Güler, N., & Altınel, Z. (2021). A Rare Adverse Effect of Cetirizine in a 7- Month-Old Infant: Dystonic Reaction. Journal of Child, 21(2), 215-217. https://doi.org/10.26650/jchild.2021.755569


AMA

Süleyman A, Özek Yücel E, Hızlı Demirkale Z, Sipahi Çimen S, Kılıç A, Özdemir C, Güler N, Altınel Z. A Rare Adverse Effect of Cetirizine in a 7- Month-Old Infant: Dystonic Reaction. Journal of Child. 2021;21(2):215-217. https://doi.org/10.26650/jchild.2021.755569


ABNT

Süleyman, A.; Özek Yücel, E.; Hızlı Demirkale, Z.; Sipahi Çimen, S.; Kılıç, A.; Özdemir, C.; Güler, N.; Altınel, Z. A Rare Adverse Effect of Cetirizine in a 7- Month-Old Infant: Dystonic Reaction. Journal of Child, [Publisher Location], v. 21, n. 2, p. 215-217, 2021.


Chicago: Author-Date Style

Süleyman, Ayşe, and Esra Özek Yücel and Zeynep Hızlı Demirkale and Sevgi Sipahi Çimen and Ayşe Kılıç and Cevdet Özdemir and Nermin Güler and Zeynep Altınel. 2021. “A Rare Adverse Effect of Cetirizine in a 7- Month-Old Infant: Dystonic Reaction.” Journal of Child 21, no. 2: 215-217. https://doi.org/10.26650/jchild.2021.755569


Chicago: Humanities Style

Süleyman, Ayşe, and Esra Özek Yücel and Zeynep Hızlı Demirkale and Sevgi Sipahi Çimen and Ayşe Kılıç and Cevdet Özdemir and Nermin Güler and Zeynep Altınel. “A Rare Adverse Effect of Cetirizine in a 7- Month-Old Infant: Dystonic Reaction.” Journal of Child 21, no. 2 (Dec. 2024): 215-217. https://doi.org/10.26650/jchild.2021.755569


Harvard: Australian Style

Süleyman, A & Özek Yücel, E & Hızlı Demirkale, Z & Sipahi Çimen, S & Kılıç, A & Özdemir, C & Güler, N & Altınel, Z 2021, 'A Rare Adverse Effect of Cetirizine in a 7- Month-Old Infant: Dystonic Reaction', Journal of Child, vol. 21, no. 2, pp. 215-217, viewed 23 Dec. 2024, https://doi.org/10.26650/jchild.2021.755569


Harvard: Author-Date Style

Süleyman, A. and Özek Yücel, E. and Hızlı Demirkale, Z. and Sipahi Çimen, S. and Kılıç, A. and Özdemir, C. and Güler, N. and Altınel, Z. (2021) ‘A Rare Adverse Effect of Cetirizine in a 7- Month-Old Infant: Dystonic Reaction’, Journal of Child, 21(2), pp. 215-217. https://doi.org/10.26650/jchild.2021.755569 (23 Dec. 2024).


MLA

Süleyman, Ayşe, and Esra Özek Yücel and Zeynep Hızlı Demirkale and Sevgi Sipahi Çimen and Ayşe Kılıç and Cevdet Özdemir and Nermin Güler and Zeynep Altınel. “A Rare Adverse Effect of Cetirizine in a 7- Month-Old Infant: Dystonic Reaction.” Journal of Child, vol. 21, no. 2, 2021, pp. 215-217. [Database Container], https://doi.org/10.26650/jchild.2021.755569


Vancouver

Süleyman A, Özek Yücel E, Hızlı Demirkale Z, Sipahi Çimen S, Kılıç A, Özdemir C, Güler N, Altınel Z. A Rare Adverse Effect of Cetirizine in a 7- Month-Old Infant: Dystonic Reaction. Journal of Child [Internet]. 23 Dec. 2024 [cited 23 Dec. 2024];21(2):215-217. Available from: https://doi.org/10.26650/jchild.2021.755569 doi: 10.26650/jchild.2021.755569


ISNAD

Süleyman, Ayşe - Özek Yücel, Esra - Hızlı Demirkale, Zeynep - Sipahi Çimen, Sevgi - Kılıç, Ayşe - Özdemir, Cevdet - Güler, Nermin - Altınel, Zeynep. “A Rare Adverse Effect of Cetirizine in a 7- Month-Old Infant: Dystonic Reaction”. Journal of Child 21/2 (Dec. 2024): 215-217. https://doi.org/10.26650/jchild.2021.755569



TIMELINE


Submitted18.09.2020
Accepted13.07.2021
Published Online07.09.2021

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