Change of Vitamin D level in Children with Acute Lower Respiratory  Tract Infection According to Age, Gender and Season

Arıkan Kamile; Çelebi Tayfur Aslı

doi:https://dx.doi.org/10.26650/jchild.2021.2.798556

Research Article

DOI :10.26650/jchild.2021.2.798556 IUP :10.26650/jchild.2021.2.798556 Full Text (PDF)

Change of Vitamin D level in Children with Acute Lower Respiratory Tract Infection According to Age, Gender and Season

Objective: Lower respiratory tract infections (LRTI) are the most common reason of mortality for under 5 years old. We aimed to examine serum 25 (OH) vitamin D level of children with LRTI according to age, time of admission and gender. Methods: Children between 1 months-18 years of age with a diagnosis of LRTI admitted to the Health Science University Keciören Research and Training Hospital between July 2018 and July 2019 were included. Sociodemographic characteristics, serum 25 (OH) vitamin D levels, history of recurrent LRTI, and hospitalisation time were recorded. Results: A total of 105 patients, 65 (61.9%) male (M/F:1.6) with a median age of 4 years (1 month-17 years) were included. Twenty nine patients (27.6%) were hospitalised and 76 (72.6%) patients were outpatients. Of them, 44 patients were diagnosed with viral acute lower respiratory tract infection and the remaining 61 with bacterial acute lower respiratory tract infection. Serum 25 (OH) vitamin D level was low in 63 patients (<20 ng/ mL), and normal in 42 patients (≥20 ng/mL). In 24 patients (22.9%), serum 25 (OH) vitamin D level was <12 ng/mL, in 37 (35.2%) patients, it was in 12-20 ng/mL, and in 44 (41.9%) patients, >20 ng/mL. In 32 patients under 1 year old of age, median serum 25 (OH) vitamin D levels were lower in patients born in winter compared to patients born in other seasons. The serum median 25 (OH) vitamin D level of hospitalised children under 1 year old of age was statistically significantly lower than in outpatients of the same age group, [25.9 ng/mL (1.7-87.7) versus 42.1 ng/mL (16.6- 62.6), p=0.035]. Conclusion: We conclude that, vitamin D deficiency/insufficiency may be a risk factor for LRTI presentation, recurrence and outcome in children.

Keywords: Lower respiratory tract infection, serum 25 (OH) vitamin D level, recurrent pneumonia, vitamin D insufficiency

DOI :10.26650/jchild.2021.2.798556 IUP :10.26650/jchild.2021.2.798556 Full Text (PDF)

Akut Alt Solunum Yolu Enfeksiyonu Tanılı Çocuk Hastalarda D Vitamini Düzeylerinin Yaş, Cinsiyet ve Mevsimlere Göre Değişimi

Kamile Arıkan, Aslı Çelebi Tayfur

Amaç: Akut alt solunum yolu enfeksiyonları (ASE) 5 yaş altı çocuklardaki ölümlerinin en sık nedenini oluşturur. Bu çalışmada akut ASE tanısı alan hastalarda serum 25 (OH) vitamin D düzeylerinin yaş gruplarına göre incelenmesi planlanmıştır. Metod: Çalışmaya Sağlık Bilimleri Üniversitesi Ankara Keçiören Eğitim ve Araştırma Hastanesi’nde Temmuz 2018-Temmuz 2019 tarihleri arasında ASE tanısı ile izlenen 1 ay-18 yaş aralığında çocuk hastalar dahil edildi. Hastaların hastaneye başvuru şikayeti, sosyodemografik özellikleri, serum 25 (OH) vitamin D düzeyi, hastaneye yatış öyküsü ve yatış süresi kaydedildi. Bulgular: Çalışmaya ortanca yaşı 4 yaş (1 ay-17 yaş) olan 65’i (%61,9) erkek (E/K:1,6) toplam 105 hasta dahil edildi. Yirmi dokuz (%27,6) hasta yatırılarak, 76 (%72,6) hasta ayaktan takip edildi. Hastaların 44’ü viral akut alt solunum yolu enfeksiyonu, 61’i bakteriyel akut alt solunum yolu enfeksiyonu tanısı ile izlenmiştir. Serum 25 (OH) vitamin D düzeyi hastaların 63’ünde düşük (<20 ng/mL), 42’sinde normal (≥20 ng/mL) olarak saptandı. Yirmi dört (%22,9) hastanın serum 25 (OH) vitamin D düzeyi <12 ng/mL, 37 (%35,2) hastanın 12-20 ng/mL arasında, 44 (%41,9) hastanın >20 ng/mL olarak saptandı. Çalışmaya dahil edilen 1 yaş altındaki 32 hastanın kış mevsiminde doğanlarında tanı anında ortanca serum 25 (OH) vitamin D düzeyleri, diğer mevsimlerde doğan 1 yaş altındaki hastalara göre daha düşük saptandı. Bir yaşından küçük ve akut ASE nedeni ile yatırılarak tedavi edilen hastaların serum ortanca 25 (OH) vitamin D düzeyi [25,9 ng/mL (1,7-87,7)], ayaktan tedavi edilen 1 yaşından küçük hastalarınkine [42,1 ng/mL (16,6-62,6)] göre daha düşük bulundu (p=0,035). Sonuç: Çalışmamızda akut ASE tanısı ile izlenen hastalarda serum vitamin D eksikliği/yetersizliğinin sık olarak saptanması, vitamin D düşüklüğünün çocuklarda akut ASE’nin gelişiminde ve ilerlemesinde önemli bir risk faktörü olduğunu düşündürmüştür.

Keywords: Akut alt solunum yolu enfeksiyonu, serum 25 (OH) vitamin D düzeyi, tekrarlayan pnömoni, vitamin D eksikliği

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APA

Arıkan, K., & Çelebi Tayfur, A. (2021). Change of Vitamin D level in Children with Acute Lower Respiratory Tract Infection According to Age, Gender and Season. Journal of Child, 21(2), 94-98. https://doi.org/10.26650/jchild.2021.2.798556

AMA

Arıkan K, Çelebi Tayfur A. Change of Vitamin D level in Children with Acute Lower Respiratory Tract Infection According to Age, Gender and Season. Journal of Child. 2021;21(2):94-98. https://doi.org/10.26650/jchild.2021.2.798556

ABNT

Arıkan, K.; Çelebi Tayfur, A. Change of Vitamin D level in Children with Acute Lower Respiratory Tract Infection According to Age, Gender and Season. Journal of Child, [Publisher Location], v. 21, n. 2, p. 94-98, 2021.

Chicago: Author-Date Style

Arıkan, Kamile, and Aslı Çelebi Tayfur. 2021. “Change of Vitamin D level in Children with Acute Lower Respiratory Tract Infection According to Age, Gender and Season.” Journal of Child 21, no. 2: 94-98. https://doi.org/10.26650/jchild.2021.2.798556

Chicago: Humanities Style

Arıkan, Kamile, and Aslı Çelebi Tayfur. “Change of Vitamin D level in Children with Acute Lower Respiratory Tract Infection According to Age, Gender and Season.” Journal of Child 21, no. 2 (Dec. 2024): 94-98. https://doi.org/10.26650/jchild.2021.2.798556

Harvard: Australian Style

Arıkan, K & Çelebi Tayfur, A 2021, 'Change of Vitamin D level in Children with Acute Lower Respiratory Tract Infection According to Age, Gender and Season', Journal of Child, vol. 21, no. 2, pp. 94-98, viewed 23 Dec. 2024, https://doi.org/10.26650/jchild.2021.2.798556

Harvard: Author-Date Style

Arıkan, K. and Çelebi Tayfur, A. (2021) ‘Change of Vitamin D level in Children with Acute Lower Respiratory Tract Infection According to Age, Gender and Season’, Journal of Child, 21(2), pp. 94-98. https://doi.org/10.26650/jchild.2021.2.798556 (23 Dec. 2024).

MLA

Arıkan, Kamile, and Aslı Çelebi Tayfur. “Change of Vitamin D level in Children with Acute Lower Respiratory Tract Infection According to Age, Gender and Season.” Journal of Child, vol. 21, no. 2, 2021, pp. 94-98. [Database Container], https://doi.org/10.26650/jchild.2021.2.798556

Vancouver

Arıkan K, Çelebi Tayfur A. Change of Vitamin D level in Children with Acute Lower Respiratory Tract Infection According to Age, Gender and Season. Journal of Child [Internet]. 23 Dec. 2024 [cited 23 Dec. 2024];21(2):94-98. Available from: https://doi.org/10.26650/jchild.2021.2.798556 doi: 10.26650/jchild.2021.2.798556

ISNAD

Arıkan, Kamile - Çelebi Tayfur, Aslı. “Change of Vitamin D level in Children with Acute Lower Respiratory Tract Infection According to Age, Gender and Season”. Journal of Child 21/2 (Dec. 2024): 94-98. https://doi.org/10.26650/jchild.2021.2.798556

Volume 21, Issue 22021, P. 94-98

TIMELINE

Submitted	23.09.2020
Accepted	13.07.2021
Published Online	07.09.2021

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