Journal of Child

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Case Report


DOI :10.5222/j.child.2018.99705   IUP :10.5222/j.child.2018.99705    Full Text (PDF)

Successful Treatment of Invasive Fungal Infection with Posaconazole in a 3 -Year- Old Child with Acute Lymphoblastic Leukemia

Gül Nihal Özdemir, Başak Koç, Serda Kantarcıoğlu, Sebuh Kuruoğlu, Tülin Tiraje Celkan

Invasive fungal infections, especially non-Candida albicans, are increasing because of the increasing number of immunocompromised patients and resistance to fungal infectons. New drugs for the treatment of antifungal infections have been developed in the last decade. We report a 3-year-old girl with acute lymphoblastic leukemia who developed invasive Candida infection caused by Candida albicans. Despite single and combined therapy with liposomal amphotericin B, caspofungin and voriconazole, patient’s fever and clinical condition were improved only after addition of posaconazole to the treatment. During maintenance therapy (BFM-95 ALL treatment for standard risk group) for ALL, fungal infection remained under control and did not recur under posaconazole prophylaxis. 

Keywords: Candida albicans, fungal infection, anti-fungal
DOI :10.5222/j.child.2018.99705   IUP :10.5222/j.child.2018.99705    Full Text (PDF)

Akut Lenfoblastik Lösemili Üç yaşında Bir Çocukta İnvaziv Mantar Enfeksiyonunun Posakonazol ile Başarılı Tedavisi

Gül Nihal Özdemir, Başak Koç, Serda Kantarcıoğlu, Sebuh Kuruoğlu, Tülin Tiraje Celkan

İnvaziv mantar enfeksiyonları, özellikle albicans dışı Candida gibi mayalar, artan immün-baskılanmış hasta sayısı ve oluşan mantar direnci nedeniyle artış göstermektedir. Son on yılda bu enfeksiyonların tedavisi için yeni antifungal ilaçlar geliştirilmiştir. Bu yazıda akut lenfoblastik lösemili 3 yaşında bir kız çocukta Candida albicans’a bağlı gelişen invazif kandida enfeksiyonu bildirilmiştir. Lipozomal amfoterisin B, kaspofungin ve vorikonazolün tek başına ve bu ilaçların birlikte tedavisine rağmen hastanın ateşi ve klinik durumunda düzelme olmamış, tedaviye posakonazol eklenmesiyle düzelme görülmüştür. Devam tedavisi sırasında mantar enfeksiyonu kontrol altında kalmış ve posakonazol profilaksisi altında tekrarlamamıştır. 

Keywords: Candida albicans, mantar enfeksiyonu, antifungal

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APA

Özdemir, G.N., Koç, B., Kantarcıoğlu, S., Kuruoğlu, S., & Celkan, T.T. (2018). Successful Treatment of Invasive Fungal Infection with Posaconazole in a 3 -Year- Old Child with Acute Lymphoblastic Leukemia. Journal of Child, 18(3), 144-149. https://doi.org/10.5222/j.child.2018.99705


AMA

Özdemir G N, Koç B, Kantarcıoğlu S, Kuruoğlu S, Celkan T T. Successful Treatment of Invasive Fungal Infection with Posaconazole in a 3 -Year- Old Child with Acute Lymphoblastic Leukemia. Journal of Child. 2018;18(3):144-149. https://doi.org/10.5222/j.child.2018.99705


ABNT

Özdemir, G.N.; Koç, B.; Kantarcıoğlu, S.; Kuruoğlu, S.; Celkan, T.T. Successful Treatment of Invasive Fungal Infection with Posaconazole in a 3 -Year- Old Child with Acute Lymphoblastic Leukemia. Journal of Child, [Publisher Location], v. 18, n. 3, p. 144-149, 2018.


Chicago: Author-Date Style

Özdemir, Gül Nihal, and Başak Koç and Serda Kantarcıoğlu and Sebuh Kuruoğlu and Tülin Tiraje Celkan. 2018. “Successful Treatment of Invasive Fungal Infection with Posaconazole in a 3 -Year- Old Child with Acute Lymphoblastic Leukemia.” Journal of Child 18, no. 3: 144-149. https://doi.org/10.5222/j.child.2018.99705


Chicago: Humanities Style

Özdemir, Gül Nihal, and Başak Koç and Serda Kantarcıoğlu and Sebuh Kuruoğlu and Tülin Tiraje Celkan. “Successful Treatment of Invasive Fungal Infection with Posaconazole in a 3 -Year- Old Child with Acute Lymphoblastic Leukemia.” Journal of Child 18, no. 3 (May. 2025): 144-149. https://doi.org/10.5222/j.child.2018.99705


Harvard: Australian Style

Özdemir, GN & Koç, B & Kantarcıoğlu, S & Kuruoğlu, S & Celkan, TT 2018, 'Successful Treatment of Invasive Fungal Infection with Posaconazole in a 3 -Year- Old Child with Acute Lymphoblastic Leukemia', Journal of Child, vol. 18, no. 3, pp. 144-149, viewed 22 May. 2025, https://doi.org/10.5222/j.child.2018.99705


Harvard: Author-Date Style

Özdemir, G.N. and Koç, B. and Kantarcıoğlu, S. and Kuruoğlu, S. and Celkan, T.T. (2018) ‘Successful Treatment of Invasive Fungal Infection with Posaconazole in a 3 -Year- Old Child with Acute Lymphoblastic Leukemia’, Journal of Child, 18(3), pp. 144-149. https://doi.org/10.5222/j.child.2018.99705 (22 May. 2025).


MLA

Özdemir, Gül Nihal, and Başak Koç and Serda Kantarcıoğlu and Sebuh Kuruoğlu and Tülin Tiraje Celkan. “Successful Treatment of Invasive Fungal Infection with Posaconazole in a 3 -Year- Old Child with Acute Lymphoblastic Leukemia.” Journal of Child, vol. 18, no. 3, 2018, pp. 144-149. [Database Container], https://doi.org/10.5222/j.child.2018.99705


Vancouver

Özdemir GN, Koç B, Kantarcıoğlu S, Kuruoğlu S, Celkan TT. Successful Treatment of Invasive Fungal Infection with Posaconazole in a 3 -Year- Old Child with Acute Lymphoblastic Leukemia. Journal of Child [Internet]. 22 May. 2025 [cited 22 May. 2025];18(3):144-149. Available from: https://doi.org/10.5222/j.child.2018.99705 doi: 10.5222/j.child.2018.99705


ISNAD

Özdemir, GülNihal - Koç, Başak - Kantarcıoğlu, Serda - Kuruoğlu, Sebuh - Celkan, TülinTiraje. “Successful Treatment of Invasive Fungal Infection with Posaconazole in a 3 -Year- Old Child with Acute Lymphoblastic Leukemia”. Journal of Child 18/3 (May. 2025): 144-149. https://doi.org/10.5222/j.child.2018.99705



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Published Online31.12.2018

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