Journal of Child

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DOI :10.26650/jchild.2021.875023   IUP :10.26650/jchild.2021.875023    Full Text (PDF)

Alloimmune Cytopenias

Selime Aydoğdu

Immune cytopenias occur as a result of the destruction of erythrocytes, platelets, and neutrophils or more than one cell line at the same time through the immune system stimulated by autoantibodies or alloantibodies. Alloantibodies are formed when the organism is stimulated when it encounters antigens of the same type, called alloantigen or isoantigen, and which do not belong to it. Examples include blood group antigens and tissue group antigens. These antibodies usually cause the destruction of blood cells for a temporary period. Autoimmunity, on the other hand, is when the immune tolerance is disrupted and the entire defence system of the organism sees its own antigens as foreign and causes the destruction/damage of the cells. Autoimmune diseases can affect all organ systems. Alloimmunization may present with blood transfusion reactions, neonatal cytopenias or graft rejection after organ transplantation. In this article, blood transfusion reactions and alloimmune cytopenias of newborns will be discussed. 

Keywords: Alloimmunisation, cytopenia, neonate, child
DOI :10.26650/jchild.2021.875023   IUP :10.26650/jchild.2021.875023    Full Text (PDF)

Alloimmun Sitopeniler

Selime Aydoğdu

İmmunsitopeniler eritrosit, trombosit ve nötrofillerin veya aynı anda birden fazla hücre serisinin “otoantikorlar” veya “alloantikorlar” tarafından uyarılmış immun sistem aracılığı ile yıkımı sonucu meydana gelir. Alloantikorlar, organizmanın karşılaştığı alloantijen veya izoantijen denilen aynı türden ve kendine ait olmayan antijenlerle uyarılması ile oluşur. Kan grubu ve doku grubu antijenleri bunlara örnek olarak gösterilebilir. Oluşan bu antikorlar genellikle geçici bir dönem kan hücrelerinin yıkımına neden olurlar. Otoimunite ise immun toleransın bozularak organizmanın tüm savunma sisteminin kendi antijenlerini yabancı görmesi ve hücrelerin yıkımına/ hasarına yol açmasıdır. Otoimmun hastalıklar tüm organ sistemlerini etkileyebilir. Alloimmunizasyon kan transfüzyonu reaksiyonları, yenidoğan sitopenileri veya organ transplantasyonu sonrası görülen greft rejekti ile karşımıza çıkabilir. Bu yazıda kan transfüzyonu reaksiyonları ve yenidoğanın alloimmunsitopenilerinden bahsedilecektir.

Keywords: Alloimmunizasyon, sitopeni, yenidoğan, çocuk

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APA

Aydoğdu, S. (2021). Alloimmune Cytopenias. Journal of Child, 21(2), 207-211. https://doi.org/10.26650/jchild.2021.875023


AMA

Aydoğdu S. Alloimmune Cytopenias. Journal of Child. 2021;21(2):207-211. https://doi.org/10.26650/jchild.2021.875023


ABNT

Aydoğdu, S. Alloimmune Cytopenias. Journal of Child, [Publisher Location], v. 21, n. 2, p. 207-211, 2021.


Chicago: Author-Date Style

Aydoğdu, Selime,. 2021. “Alloimmune Cytopenias.” Journal of Child 21, no. 2: 207-211. https://doi.org/10.26650/jchild.2021.875023


Chicago: Humanities Style

Aydoğdu, Selime,. “Alloimmune Cytopenias.” Journal of Child 21, no. 2 (Dec. 2024): 207-211. https://doi.org/10.26650/jchild.2021.875023


Harvard: Australian Style

Aydoğdu, S 2021, 'Alloimmune Cytopenias', Journal of Child, vol. 21, no. 2, pp. 207-211, viewed 23 Dec. 2024, https://doi.org/10.26650/jchild.2021.875023


Harvard: Author-Date Style

Aydoğdu, S. (2021) ‘Alloimmune Cytopenias’, Journal of Child, 21(2), pp. 207-211. https://doi.org/10.26650/jchild.2021.875023 (23 Dec. 2024).


MLA

Aydoğdu, Selime,. “Alloimmune Cytopenias.” Journal of Child, vol. 21, no. 2, 2021, pp. 207-211. [Database Container], https://doi.org/10.26650/jchild.2021.875023


Vancouver

Aydoğdu S. Alloimmune Cytopenias. Journal of Child [Internet]. 23 Dec. 2024 [cited 23 Dec. 2024];21(2):207-211. Available from: https://doi.org/10.26650/jchild.2021.875023 doi: 10.26650/jchild.2021.875023


ISNAD

Aydoğdu, Selime. “Alloimmune Cytopenias”. Journal of Child 21/2 (Dec. 2024): 207-211. https://doi.org/10.26650/jchild.2021.875023



TIMELINE


Submitted05.02.2021
Accepted03.08.2021
Published Online07.09.2021

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