The Comparison of the Effectiveness of Leukotriene Receptor Antagonists and Inhaled Corticosteroids in Children with Asthma

Bostan Gayret, Özlem; Öktem, Sedat; Tokuç, Ayşe

doi:https://dx.doi.org/10.5222/j.child.2018.30974

Research Article

DOI :10.5222/j.child.2018.30974 IUP :10.5222/j.child.2018.30974 Full Text (PDF)

The Comparison of the Effectiveness of Leukotriene Receptor Antagonists and Inhaled Corticosteroids in Children with Asthma

Özlem Bostan Gayret, Sedat Öktem, Ayşe Gülnur Tokuç

Objection: The leukotriene antagonists and inhaled corticosteroids are used in the treatment of childhood asthma. This study was conducted to compare the effectiveness of the leukotriene receptor antagonist and inhaled corticosteroid treatment in children diagnosed with asthma. Material and Methods: Sixty - two patients diagnosed with asthma in the age group of 6-14 years were included in the study. Patients were consecutively divided into 2 groups, and the first group was given 5 mg of montelukast before sleep and the second group received 400 mcg/day of inhaled corticosteroid (budesonide) in two doses. The patients were followed up for 6 months. Primary target were changes in the FEV1. Furthermore, daily short-acting β2 agonist use, night awakenings, admission to the emergency department, absenteeism at school were compared before and after the treatment. Results: Significant improvement was observed in both groups during postoperative period when compared to the pre-treatment period in terms of the mean FEV1, shortacting β2 agonist use, night awakenings, admission to the emergency department, and absenteeism at school (p=0,001). However, no statistical difference was determined between two groups. Conclusion: It was determined that montelukast therapy alone in children with asthma is an easy-to-administer and safe option, which is as effective as inhaled corticosteroids.

Keywords: asthma, montelukast, inhaled steroid

DOI :10.5222/j.child.2018.30974 IUP :10.5222/j.child.2018.30974 Full Text (PDF)

Astımlı Çocuklarda Lökotrien Reseptör Antagonisti ile İnhale Kortikosteroid Etkinliğinin Karşılaştırılması

Özlem Bostan Gayret, Sedat Öktem, Ayşe Gülnur Tokuç

Amaç: Çocukluk çağı astım tedavisinde lökotrien antagonisti ile inhale kortikosteroidler kullanılmaktadır. Çalışma, astım tanısı almış çocuklarda lökotrien reseptör antagonisti ile inhale kortikosteroid tedavisinin etkinliğini karşılaştırmak için yapılmıştır. Gereç ve Yöntem: Çalışmaya 6-14 yaş grubunda astım tanısı alan 62 hasta dâhil edildi. Hastalar ardışık iki gruba ayrılarak birinci gruba montelukast gece yatmadan önce 5 mg, ikinci gruba inhale kortikosteroid (budesonide) 400 mcg/gün 2 doza bölünerek verildi. Hastalar 6 ay süreyle takip edildi. Değerlendirmede FEV1’deki değişiklikler birincil hedef alındı. Ayrıca tedavi öncesi ve sonrası günlük kısa etkili β2 agonist kullanımı, gece uyanma, acile başvuru, okula devamsızlık değerleri ile karşılaştırıldı. Bulgular: Tedavi sonrasında, tedavi öncesine göre her iki grupta; FEV1 ortalamasında, kısa etkili β2 agonist kullanımı, gece uyanma, acile başvuru ve okula devamsızlık açısından ileri düzeyde düzelme görüldü (p=0,001). Ancak, iki grup arasında istatistiki fark saptanmadı. Sonuç: Astımlı çocuklarda tek başına monlelukast tedavisi; kolay uygulanabilir, güvenilir ve inhale kortikosteroidler kadar etkili bir seçenek olarak saptanmıştır.

Keywords: Astım, montelukast, inhale kortikosteroid

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APA

Bostan Gayret, Ö., Öktem, S., & Tokuç, A.G. (2018). The Comparison of the Effectiveness of Leukotriene Receptor Antagonists and Inhaled Corticosteroids in Children with Asthma. Journal of Child, 18(1), 24-28. https://doi.org/10.5222/j.child.2018.30974

AMA

Bostan Gayret Ö, Öktem S, Tokuç A G. The Comparison of the Effectiveness of Leukotriene Receptor Antagonists and Inhaled Corticosteroids in Children with Asthma. Journal of Child. 2018;18(1):24-28. https://doi.org/10.5222/j.child.2018.30974

ABNT

Bostan Gayret, Ö.; Öktem, S.; Tokuç, A.G. The Comparison of the Effectiveness of Leukotriene Receptor Antagonists and Inhaled Corticosteroids in Children with Asthma. Journal of Child, [Publisher Location], v. 18, n. 1, p. 24-28, 2018.

Chicago: Author-Date Style

Bostan Gayret, Özlem, and Sedat Öktem and Ayşe Gülnur Tokuç. 2018. “The Comparison of the Effectiveness of Leukotriene Receptor Antagonists and Inhaled Corticosteroids in Children with Asthma.” Journal of Child 18, no. 1: 24-28. https://doi.org/10.5222/j.child.2018.30974

Chicago: Humanities Style

Bostan Gayret, Özlem, and Sedat Öktem and Ayşe Gülnur Tokuç. “The Comparison of the Effectiveness of Leukotriene Receptor Antagonists and Inhaled Corticosteroids in Children with Asthma.” Journal of Child 18, no. 1 (Jun. 2025): 24-28. https://doi.org/10.5222/j.child.2018.30974

Harvard: Australian Style

Bostan Gayret, Ö & Öktem, S & Tokuç, AG 2018, 'The Comparison of the Effectiveness of Leukotriene Receptor Antagonists and Inhaled Corticosteroids in Children with Asthma', Journal of Child, vol. 18, no. 1, pp. 24-28, viewed 6 Jun. 2025, https://doi.org/10.5222/j.child.2018.30974

Harvard: Author-Date Style

Bostan Gayret, Ö. and Öktem, S. and Tokuç, A.G. (2018) ‘The Comparison of the Effectiveness of Leukotriene Receptor Antagonists and Inhaled Corticosteroids in Children with Asthma’, Journal of Child, 18(1), pp. 24-28. https://doi.org/10.5222/j.child.2018.30974 (6 Jun. 2025).

MLA

Bostan Gayret, Özlem, and Sedat Öktem and Ayşe Gülnur Tokuç. “The Comparison of the Effectiveness of Leukotriene Receptor Antagonists and Inhaled Corticosteroids in Children with Asthma.” Journal of Child, vol. 18, no. 1, 2018, pp. 24-28. [Database Container], https://doi.org/10.5222/j.child.2018.30974

Vancouver

Bostan Gayret Ö, Öktem S, Tokuç AG. The Comparison of the Effectiveness of Leukotriene Receptor Antagonists and Inhaled Corticosteroids in Children with Asthma. Journal of Child [Internet]. 6 Jun. 2025 [cited 6 Jun. 2025];18(1):24-28. Available from: https://doi.org/10.5222/j.child.2018.30974 doi: 10.5222/j.child.2018.30974

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Bostan Gayret, Özlem - Öktem, Sedat - Tokuç, AyşeGülnur. “The Comparison of the Effectiveness of Leukotriene Receptor Antagonists and Inhaled Corticosteroids in Children with Asthma”. Journal of Child 18/1 (Jun. 2025): 24-28. https://doi.org/10.5222/j.child.2018.30974

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The Comparison of the Effectiveness of Leukotriene Receptor Antagonists and Inhaled Corticosteroids in Children with Asthma

Astımlı Çocuklarda Lökotrien Reseptör Antagonisti ile İnhale Kortikosteroid Etkinliğinin Karşılaştırılması

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