Journal of Child

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Research Article


DOI :10.26650/jchild.2023.1253446   IUP :10.26650/jchild.2023.1253446    Full Text (PDF)

Clinical Characteristics and Short-term Outcomes of Paediatric Patients with Chronic Recurrent Multifocal Osteomyelitis

Özge Baba, Hasan Kısaoğlu, Mukaddes Kalyoncu

Objective: Chronic recurrent multifocal osteomyelitis (CRMO) is the most common autoinflammatory disease of the bone characterized by pain and inflammatory lesions without an infectious agent. The aim of this study is to evaluate the clinical, laboratory, and imaging features and treatments of paediatric patients with CRMO followed in our pediatric rheumatology clinic.

Material and Methods: Medical records of ten patients diagnosed with CRMO according to Bristol diagnostic criteria between January 2018 and June 2021 were retrospectively reviewed.

Results: The mean age at diagnosis was 9.3 years, and eight of the patients were male. One patient had concomitant psoriasis, two patients had familial Mediterranean fever and one patient had a history of immunoglobulin A vasculitis. Half of the patients had a moderate acute phase reactant elevation. The most frequently involved bones were the lower extremity bones. While localized magnetic resonance imaging (MRI) was the most commonly used imaging modality in the diagnosis of CRMO, silent bone lesions (15%) were detected only by the whole-body MRI. Non-steroidal anti-inflammatory drug (NSAID) was given to all patients. As second-line therapy, methotrexate and pamidronate were employed on seven and five patients respectively. Three of the patients received anti-TNF treatment (etanercept and infliximab) as the third-line therapy. Imaging with whole-body MRI is important due to clinically silent bone lesions, especially in the course of CRMO.

Conclusion: Concomitant familial Mediterranean fever was not rare in cases with CRMO and treatment of CRMO might be challenging due to the need for anti-TNF treatment in a considerable number of patients.

Keywords: Bone, Chronic Recurrent Multifocal Osteomyelitis, Familial Mediterranean Fever, Pamidronate, Whole Body Imaging

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APA

Baba, Ö., Kısaoğlu, H., & Kalyoncu, M. (2023). Clinical Characteristics and Short-term Outcomes of Paediatric Patients with Chronic Recurrent Multifocal Osteomyelitis. Journal of Child, 23(4), 334-338. https://doi.org/10.26650/jchild.2023.1253446


AMA

Baba Ö, Kısaoğlu H, Kalyoncu M. Clinical Characteristics and Short-term Outcomes of Paediatric Patients with Chronic Recurrent Multifocal Osteomyelitis. Journal of Child. 2023;23(4):334-338. https://doi.org/10.26650/jchild.2023.1253446


ABNT

Baba, Ö.; Kısaoğlu, H.; Kalyoncu, M. Clinical Characteristics and Short-term Outcomes of Paediatric Patients with Chronic Recurrent Multifocal Osteomyelitis. Journal of Child, [Publisher Location], v. 23, n. 4, p. 334-338, 2023.


Chicago: Author-Date Style

Baba, Özge, and Hasan Kısaoğlu and Mukaddes Kalyoncu. 2023. “Clinical Characteristics and Short-term Outcomes of Paediatric Patients with Chronic Recurrent Multifocal Osteomyelitis.” Journal of Child 23, no. 4: 334-338. https://doi.org/10.26650/jchild.2023.1253446


Chicago: Humanities Style

Baba, Özge, and Hasan Kısaoğlu and Mukaddes Kalyoncu. “Clinical Characteristics and Short-term Outcomes of Paediatric Patients with Chronic Recurrent Multifocal Osteomyelitis.” Journal of Child 23, no. 4 (Apr. 2024): 334-338. https://doi.org/10.26650/jchild.2023.1253446


Harvard: Australian Style

Baba, Ö & Kısaoğlu, H & Kalyoncu, M 2023, 'Clinical Characteristics and Short-term Outcomes of Paediatric Patients with Chronic Recurrent Multifocal Osteomyelitis', Journal of Child, vol. 23, no. 4, pp. 334-338, viewed 27 Apr. 2024, https://doi.org/10.26650/jchild.2023.1253446


Harvard: Author-Date Style

Baba, Ö. and Kısaoğlu, H. and Kalyoncu, M. (2023) ‘Clinical Characteristics and Short-term Outcomes of Paediatric Patients with Chronic Recurrent Multifocal Osteomyelitis’, Journal of Child, 23(4), pp. 334-338. https://doi.org/10.26650/jchild.2023.1253446 (27 Apr. 2024).


MLA

Baba, Özge, and Hasan Kısaoğlu and Mukaddes Kalyoncu. “Clinical Characteristics and Short-term Outcomes of Paediatric Patients with Chronic Recurrent Multifocal Osteomyelitis.” Journal of Child, vol. 23, no. 4, 2023, pp. 334-338. [Database Container], https://doi.org/10.26650/jchild.2023.1253446


Vancouver

Baba Ö, Kısaoğlu H, Kalyoncu M. Clinical Characteristics and Short-term Outcomes of Paediatric Patients with Chronic Recurrent Multifocal Osteomyelitis. Journal of Child [Internet]. 27 Apr. 2024 [cited 27 Apr. 2024];23(4):334-338. Available from: https://doi.org/10.26650/jchild.2023.1253446 doi: 10.26650/jchild.2023.1253446


ISNAD

Baba, Özge - Kısaoğlu, Hasan - Kalyoncu, Mukaddes. “Clinical Characteristics and Short-term Outcomes of Paediatric Patients with Chronic Recurrent Multifocal Osteomyelitis”. Journal of Child 23/4 (Apr. 2024): 334-338. https://doi.org/10.26650/jchild.2023.1253446



TIMELINE


Submitted20.02.2023
Accepted27.04.2023
Published Online20.12.2023

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