Profile of Anemia in Pediatric Liver Transplant Recipients

Sütçü Murat; Cantez Mustafa; Gerenli Nelgin; Durmaz Özlem

doi:https://dx.doi.org/10.5222/j.child.2018.87004

Research Article

DOI :10.5222/j.child.2018.87004 IUP :10.5222/j.child.2018.87004 Full Text (PDF)

Profile of Anemia in Pediatric Liver Transplant Recipients

Murat Sütçü, Mustafa Serdar Cantez, Nelgin Gerenli, Özlem Durmaz

Objection: To investigate the frequency, etiology and clinical significance of anemia in pediatric liver transplant recipients according to the pre-transplant and post-transplant file records. Material and Method: The study included 81 of 97 children with complete file records who underwent liver transplantation between May 2000 and February 2011 at the Istanbul University Istanbul School of Medicine Departments of Hepatobiliary Surgery and Pediatric Hepatology. We recorded hemoglobin values before and at 1st day, 1st week and 1st month after transplantation. Results: Majority of the transplanted children were males (67.9%) and transplant recipients from living donors (76.5%). The median age of the patients was 54 months and most common indications of transplantation were cholestatic liver diseases (37%), metabolic liver disease (19.7%) and cryptogenic cirrhosis (13.5%) mostly with signs of hypersplenism. Anemia was detected before transplantation (n=50, 61.7%), first day (n=63, 77.8%), first week (n=51, 63.0%) and first month (n=41, 50.6%) of transplantation. The mean Hb values before (10.0±1.4 g/dL), and first day (9.42±1.32 g/dL), first week (9.75±1.20 g/dL), and first month (10.2±1.56 g/dL) of transplantation. The Hb change between pre- and post-transplant periods was significant. Splenomegaly was detected in 36 of 50 cases with anemia before transplantation. A significant difference was detected between splenomegaly and anemia before transplantation. Splenomegaly was detected in 19 of 41 cases with anemia in the first month of post-transplant. Conclusion: The frequency of anemia has increased during early period of transplantation (77.8% in first day) while its incidence significantly decreased by 50.6% in the first month of transplantation due to ameliorating hypersplenism. In addition, splenomegaly that has determinant role in frequency of anemia during pre-transplant period had lost its significance after transplantation.

Keywords: Child, liver transplant, anemia

DOI :10.5222/j.child.2018.87004 IUP :10.5222/j.child.2018.87004 Full Text (PDF)

Çocuk Karaciğer Nakil Alıcılarında Anemi Profili

Murat Sütçü, Mustafa Serdar Cantez, Nelgin Gerenli, Özlem Durmaz

Amaç: Karaciğer nakil alıcılarında nakil öncesi ve sonrası dosya kayıtlarından anemi sıklığı, etiyolojisi ve klinik önemi araştırıldı. Gereç ve Yöntem: Çalışmaya İstanbul Üniversitesi İstanbul Tıp Fakültesi Hepatobiliyer Cerrahi Bilim Dalı ve Pediatrik Hepatoloji Bilim Dalında Mayıs 2000 ve Şubat 2011 tarihleri arasında karaciğer nakli uygulanmış 97 çocuk hastadan dosyalarına ulaşılan 81 vaka alındı. Dosya kayıtlarından nakil öncesi ve nakil sonrası 1. gün, 1. hafta, 1. ay hematolojik bulgular kaydedildi. Bulgular: Çalışma grubunun çoğunluğu erkek cinsiyette (%67.9) ve canlı vericiden (%76.5) nakil olmuş vakalardan oluşmaktaydı. Nakil olma yaşı medyan 54 aydı ve nakil nedenlerinin çoğunluğunu hipersplenizm bulgularının eslik ettiği kolestatik karaciğer hastalıkları (%37), metabolik karaciğer hastalıkları (%19.7) ve kriptojenik siroz (%13.5) oluşturmaktaydı. Anemi nakil öncesi 50 (%61.7) vakada saptanırken nakil sonrası 1. gün 63 (%77.8), 1. hafta 51 (%63.0) ve 1. ay 41 (%50.6) vakada görüldü. Vakalarda nakil öncesi anemi varlığı ile nakil sonrası anemi varlığı arasındaki ilişki anlamlı bulundu (p<0.05). Ortalama Hb değeri nakil öncesinde 10.0±1.4 g/dL saptanırken, nakil sonrası 1. gün 9.42±1.3 g/dL, 1. hafta 9.75±1.2 g/dL, 1. ay 10.2±1.6 g/dL bulundu. Nakil öncesi ve sonrasında Hb değişimi istatiksel açıdan anlamlı bulundu. Nakil öncesi anemi saptanan 50 vakanın 36’sında splenomegali mevcuttu. Nakil öncesi anemi ile splenomegali arasında anlamlı ilişki saptandı. Nakil sonrası 1. ayda anemi saptanan 41 vakanın 19’unda splenomegali mevcuttu. Sonuçlar: Karaciğer nakli sonrası anemi sıklığı erken dönemde (1. gün %77.8) artarken, hafifleyen hipersplenizmin etkisiyle 1. ay (%50.6) anlamlı olarak azalmıştır. Ayrıca nakil öncesi anemi sıklığında belirleyici rolü olan splenomegalinin nakil sonrası dönemde önemini kaybetmektedir

Keywords: Çocuk, karaciğer nakli, anemi

References

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APA

Sütçü, M., Cantez, M.S., Gerenli, N., & Durmaz, Ö. (2018). Profile of Anemia in Pediatric Liver Transplant Recipients. Journal of Child, 18(2), 86-92. https://doi.org/10.5222/j.child.2018.87004

AMA

Sütçü M, Cantez M S, Gerenli N, Durmaz Ö. Profile of Anemia in Pediatric Liver Transplant Recipients. Journal of Child. 2018;18(2):86-92. https://doi.org/10.5222/j.child.2018.87004

ABNT

Sütçü, M.; Cantez, M.S.; Gerenli, N.; Durmaz, Ö. Profile of Anemia in Pediatric Liver Transplant Recipients. Journal of Child, [Publisher Location], v. 18, n. 2, p. 86-92, 2018.

Chicago: Author-Date Style

Sütçü, Murat, and Mustafa Serdar Cantez and Nelgin Gerenli and Özlem Durmaz. 2018. “Profile of Anemia in Pediatric Liver Transplant Recipients.” Journal of Child 18, no. 2: 86-92. https://doi.org/10.5222/j.child.2018.87004

Chicago: Humanities Style

Sütçü, Murat, and Mustafa Serdar Cantez and Nelgin Gerenli and Özlem Durmaz. “Profile of Anemia in Pediatric Liver Transplant Recipients.” Journal of Child 18, no. 2 (Nov. 2024): 86-92. https://doi.org/10.5222/j.child.2018.87004

Harvard: Australian Style

Sütçü, M & Cantez, MS & Gerenli, N & Durmaz, Ö 2018, 'Profile of Anemia in Pediatric Liver Transplant Recipients', Journal of Child, vol. 18, no. 2, pp. 86-92, viewed 5 Nov. 2024, https://doi.org/10.5222/j.child.2018.87004

Harvard: Author-Date Style

Sütçü, M. and Cantez, M.S. and Gerenli, N. and Durmaz, Ö. (2018) ‘Profile of Anemia in Pediatric Liver Transplant Recipients’, Journal of Child, 18(2), pp. 86-92. https://doi.org/10.5222/j.child.2018.87004 (5 Nov. 2024).

MLA

Sütçü, Murat, and Mustafa Serdar Cantez and Nelgin Gerenli and Özlem Durmaz. “Profile of Anemia in Pediatric Liver Transplant Recipients.” Journal of Child, vol. 18, no. 2, 2018, pp. 86-92. [Database Container], https://doi.org/10.5222/j.child.2018.87004

Vancouver

Sütçü M, Cantez MS, Gerenli N, Durmaz Ö. Profile of Anemia in Pediatric Liver Transplant Recipients. Journal of Child [Internet]. 5 Nov. 2024 [cited 5 Nov. 2024];18(2):86-92. Available from: https://doi.org/10.5222/j.child.2018.87004 doi: 10.5222/j.child.2018.87004

ISNAD

Sütçü, Murat - Cantez, MustafaSerdar - Gerenli, Nelgin - Durmaz, Özlem. “Profile of Anemia in Pediatric Liver Transplant Recipients”. Journal of Child 18/2 (Nov. 2024): 86-92. https://doi.org/10.5222/j.child.2018.87004

Volume 18, Issue 22018, P. 86-92

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31.08.2018

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Profile of Anemia in Pediatric Liver Transplant Recipients

Çocuk Karaciğer Nakil Alıcılarında Anemi Profili

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