Journal of Child

SUBMITINFORMATION
EnglishTürkçe

Review


DOI :10.5222/j.child.2016.011   IUP :10.5222/j.child.2016.011    Full Text (PDF)

Therapeutic Management and Prognosis in Benign Epilepsy with Centrotemporal Spikes in Childhood

Gonca Bektaş, Edibe Pembegül Yıldız, Meliha Mine Çalışkan

Benign epilepsy with centrotemporal spikes (rolandic epilepsy) is the most common childhood focal epilepsy syndrome. Although rolandic epilepsy is characterized by a benign clinical course, deterioration of language, behaviour, and cognitive functions have been also reported. Interictal rolandic epileptiform discharges are suggested to be a potential risk factor for neurophysiological impairment regardless of frequency of seizures. Typical clinical course of rolandic epilepsy and neurophysiological studies performed on patients with rolandic epilepsy were evaluated.

Keywords: Rolandic epilepsy, antiepileptic drugs, childhood benign epilepsy
DOI :10.5222/j.child.2016.011   IUP :10.5222/j.child.2016.011    Full Text (PDF)

Çocukluk Çağının Sentrotemporal Dikenli Selim Epilepsisinde Tedavi Yaklaşımı ve Prognoz

Gonca Bektaş, Edibe Pembegül Yıldız, Meliha Mine Çalışkan

Çocukluk çağının sentrotemporal dikenli selim epilepsisi (rolandik epilepsi), çocukluk çağında en sık görülen fokal epilepsi sendromudur. Bu hastalığın selim bir seyri olduğu kabul edilmesine karşın konuşma, davranış anormalliklerine ve kognitif bozulmaya yol açabileceği bildirilmiştir. Nöbet sıklığından bağımsız olarak, interiktal rolandik epileptiform deşarjların nörofizyolojik fonksiyonlar açısından potansiyel bir risk faktörü olduğu öne sürülmektedir. Rolandik epilepsinin tipik klinik seyri ile bu hastalar üzerinde yapılan nörofizyolojik çalışmalar irdelenmiştir.

Keywords: Rolandik epilepsi, antiepileptik ilaçlar, çocukluk çağı epilepsisi

PDF View

References

  • 1. Engel J Jr, Pedley TA, Fejerman N. Benign childhood epilepsy with centrotemporal spikes. In: Engel J Jr, Pedley TA, editors. Philadelphia: Lippincott Williams & Wilkins: A Wolters Kluwer Business; 2008. p. 2369-77. google scholar
  • 2. Panayiotopoulos CP, Michael M, Sanders S, Valeta T, Koutroumanidis M. Benign childhood focal epilepsies: assessment of established and newly recognized syndromes. Brain 2008;131:2264-86. https://doi.org/10.1093/brain/awn162 google scholar
  • 3. Larson K, Eeg-Olofsson O. A population based study of epilepsy in children from a Swedish county. Eur J Paediatr Neurol 2006;10:107-13. https://doi.org/10.1016/j.ejpn.2006.02.005 google scholar
  • 4. Parmeggiani L, Seri S, Bonanni P, Guerrini R. Electrophysiological characterization of spontaneous and carbamazepine-induced epileptic negative myoclonus in benign childhood epilepsy with centro-temporal spikes. Clin Neurophysiol 2004;115:50-8. https://doi.org/10.1016/S1388-2457(03)00327-4 google scholar
  • 5. Panayiotopoulos CP. Benign childhood partial epilepsies: benign childhood seizure susceptibility syndromes. J Neurol Neurosurg Psychiatr 1993;56:2-5. https://doi.org/10.1136/jnnp.56.1.2 google scholar
  • 6. Bali B, Kull LL, Strug LJ, Clarke T, Murphy PL, Akman CI, et al. Autosomal dominant inheritance of centrotemporal sharp waves in rolandic epilepsy families. Epilepsia 2007;48:2266-72. https://doi.org/10.1111/j.1528-1167.2007.01221.x google scholar
  • 7. Neubauer BA, Fiedler B, Himmelein B, Kampfer F, Lassker U, Schwabe G, et al. Centrotemporal spikes in families with rolandic epilepsy: linkage to chromosome 15q14. Neurology 1998;51:1608-12. https://doi.org/10.1212/WNL.51.6.1608 google scholar
  • 8. Panayiotopoulos CP. Benign childhood partial seizures and related epileptic syndromes. London: John Libbey & Company Ltd; 1999. google scholar
  • 9. Okubo Y, Matsuura M, Asai T, Asai K, Kato M, Kojima T, et al. Epileptiform EEG discharges in healthy children: prevalence, emotional and behavioral correlates, and genetic influences. Epilepsia 1994;35:832-41. https://doi.org/10.1111/j.1528-1157.1994.tb02520.x google scholar
  • 10. Verrotti A, Matricardi S, Di Giacomo DL, Rapino D, Chiarelli F, Coppola G. Neuropsychological impairment in children with Rolandic epilepsy and in their siblings. Epilepsy Behav 2013;28:108-12. https://doi.org/10.1016/j.yebeh.2013.04.005 google scholar
  • 11. Tan HJ, Singh J, Gupta R, de Goede C. Comparison of antiepileptic drugs, no treatment, or placebo for children with benign epilepsy with centro temporal spikes. Cochrane Database Syst Rev 2014; CD006779. https://doi.org/10.1002/14651858.cd006779.pub2 google scholar
  • 12. Wheless JW, Clarke DF, Arzimanoglou A, Carpenter D. Treatment of pediatric epilepsy: European expert opinion. Epileptic Disord 2007;9:353-412. google scholar
  • 13. Ben Zeev B, Watemberg N, Lerman P, Barash I, G. Bektaş ve ark., Çocukluk Çağının Sentrotemporal Dikenli Selim Epilepsisinde Tedavi Yaklaşımı ve Prognoz 15 Brand N, Lerman-Sagie T. Sulthiame in childhood epilepsy. Pediatr Int 2004;46:521-4. https://doi.org/10.1111/j.1442-200x.2004.01954.x google scholar
  • 14. Kikumoto K, Yoshinaga H, Oka M, Ito M, Endoh F, Akiyama T, et al. EEG and seizure exacerbation induced by carbamazepine in Panayiotopoulos syndrome. Epileptic Disord 2006;8:53-6. google scholar
  • 15. Xiao F, An D, Lei D, Li L, Chen S, Wu X, et al. Realtime effects of centrotemporal spikes on cognition in rolandic epilepsy: An EEG-fMRI study. Neurology 2016;86:544-51. https://doi.org/10.1212/WNL.0000000000002358 google scholar
  • 16. Aicardi J. Atypical semiology of rolandic epilepsy in some related syndromes. Epileptic Disord 2000;2 Suppl 1: S5-9. google scholar

Citations

Copy and paste a formatted citation or use one of the options to export in your chosen format


EXPORT



APA

Bektaş, G., Pembegül Yıldız, E., & Çalışkan, M.M. (2016). Therapeutic Management and Prognosis in Benign Epilepsy with Centrotemporal Spikes in Childhood. Journal of Child, 16(1), 11-15. https://doi.org/10.5222/j.child.2016.011


AMA

Bektaş G, Pembegül Yıldız E, Çalışkan M M. Therapeutic Management and Prognosis in Benign Epilepsy with Centrotemporal Spikes in Childhood. Journal of Child. 2016;16(1):11-15. https://doi.org/10.5222/j.child.2016.011


ABNT

Bektaş, G.; Pembegül Yıldız, E.; Çalışkan, M.M. Therapeutic Management and Prognosis in Benign Epilepsy with Centrotemporal Spikes in Childhood. Journal of Child, [Publisher Location], v. 16, n. 1, p. 11-15, 2016.


Chicago: Author-Date Style

Bektaş, Gonca, and Edibe Pembegül Yıldız and Meliha Mine Çalışkan. 2016. “Therapeutic Management and Prognosis in Benign Epilepsy with Centrotemporal Spikes in Childhood.” Journal of Child 16, no. 1: 11-15. https://doi.org/10.5222/j.child.2016.011


Chicago: Humanities Style

Bektaş, Gonca, and Edibe Pembegül Yıldız and Meliha Mine Çalışkan. “Therapeutic Management and Prognosis in Benign Epilepsy with Centrotemporal Spikes in Childhood.” Journal of Child 16, no. 1 (May. 2025): 11-15. https://doi.org/10.5222/j.child.2016.011


Harvard: Australian Style

Bektaş, G & Pembegül Yıldız, E & Çalışkan, MM 2016, 'Therapeutic Management and Prognosis in Benign Epilepsy with Centrotemporal Spikes in Childhood', Journal of Child, vol. 16, no. 1, pp. 11-15, viewed 23 May. 2025, https://doi.org/10.5222/j.child.2016.011


Harvard: Author-Date Style

Bektaş, G. and Pembegül Yıldız, E. and Çalışkan, M.M. (2016) ‘Therapeutic Management and Prognosis in Benign Epilepsy with Centrotemporal Spikes in Childhood’, Journal of Child, 16(1), pp. 11-15. https://doi.org/10.5222/j.child.2016.011 (23 May. 2025).


MLA

Bektaş, Gonca, and Edibe Pembegül Yıldız and Meliha Mine Çalışkan. “Therapeutic Management and Prognosis in Benign Epilepsy with Centrotemporal Spikes in Childhood.” Journal of Child, vol. 16, no. 1, 2016, pp. 11-15. [Database Container], https://doi.org/10.5222/j.child.2016.011


Vancouver

Bektaş G, Pembegül Yıldız E, Çalışkan MM. Therapeutic Management and Prognosis in Benign Epilepsy with Centrotemporal Spikes in Childhood. Journal of Child [Internet]. 23 May. 2025 [cited 23 May. 2025];16(1):11-15. Available from: https://doi.org/10.5222/j.child.2016.011 doi: 10.5222/j.child.2016.011


ISNAD

Bektaş, Gonca - Pembegül Yıldız, Edibe - Çalışkan, MelihaMine. “Therapeutic Management and Prognosis in Benign Epilepsy with Centrotemporal Spikes in Childhood”. Journal of Child 16/1 (May. 2025): 11-15. https://doi.org/10.5222/j.child.2016.011



TIMELINE


Submitted08.08.2016
Accepted20.02.2017

LICENCE


Attribution-NonCommercial (CC BY-NC)

This license lets others remix, tweak, and build upon your work non-commercially, and although their new works must also acknowledge you and be non-commercial, they don’t have to license their derivative works on the same terms.


SHARE



Istanbul University Press aims to contribute to the dissemination of ever growing scientific knowledge through publication of high quality scientific journals and books in accordance with the international publishing standards and ethics. Istanbul University Press follows an open access, non-commercial, scholarly publishing.