Evaluation of Bone Mineral Density in Prepubertal Children with  Familial Mediterranean Fever

Atağ Emine; Öcal Demir Sevliya; Ergüven Müferet

doi:https://dx.doi.org/10.26650/jchild.2021.788750

Research Article

DOI :10.26650/jchild.2021.788750 IUP :10.26650/jchild.2021.788750 Full Text (PDF)

Evaluation of Bone Mineral Density in Prepubertal Children with Familial Mediterranean Fever

Emine Atağ, Sevliya Öcal Demir, Müferet Ergüven

Objective: Familial Mediterranean Fever (FMF) is a hereditary autosomal recessive chronic periodic inflammatory disease, characterized by recurrent fever polyserositis and skin manifestations. The aim of this study was to investigate the bone mineral density (BMD) in prepubertal children with FMF and to determine the relationship between bone density and demographic, laboratory characteristics of the disease. Material and Method: Thirty two previously diagnosed, attack-free, prepubertal FMF patients who were receiving regular colchicine treatment were included in the study. Demographic and clinical data of patients, acute phase reactants, biochemical parameters of bone turnover, bone age, and L1-L4 vertebral mineral density were evaluated. The results of the patients were compared with values determined for healthy Turkish children. Results: All of the patients had z-scores which were greater than -2. Acute phase values and bone metabolism markers were within normal limits. No correlation was found between the aBMD Z-score and demographic data, acute phase reactants and bone metabolism markers. There was a negative correlation between delay in diagnosis and aBMD Z- score. Conclusion: Although aBMD Z-scores were normal in children with FMF the aBMD Z score was found to be lower in children who had had a delay in treatment. Early initiated colchicine therapy is important for optimal bone health in these patients.

Keywords: Bone mineral density, children, familial mediterranean fever

DOI :10.26650/jchild.2021.788750 IUP :10.26650/jchild.2021.788750 Full Text (PDF)

Ailevi Akdeniz Ateşi Tanısı ile İzlenen Prepubertal Çocuklarda Kemik Mineral Dansitesinin Değerlendirilmesi

Emine Atağ, Sevliya Öcal Demir, Müferet Ergüven

Amaç: Ailevi Akdeniz Ateşi (AAA) otozomal ressesif kalıtılan tekrarlayan atateş, poliserözit ve cilt bulgularıyla karakterize atakler ve remisyonla seyreden kronik periyodik inflamatuvar bir hastalıktır. Bu çalışma, AAA tanısıyla izlenen prepubertal çocuklarda kemik mineral yoğunluğunu (BMD) araştırmak ve kemik yoğunluğu ve hastalığın laboratuvar ve demografik özelikleri arasındaki ilişkiyi saptamak amacıyla yapılmıştır. Gereç ve Yöntem: Bu çalışmaya AAA tanısıyla takipli ve kolşisin tedavisi alan prepubertal 32 hasta alındı. Hastaların demografik ve klinik verileri, remisyon döneminde akut faz reaktanları, kemik döngüsünün biyokimyasal parametreleri, kemik yaşı, L1-L4 vertebra BMD ölçümleri değerlendirildi. Hastaların sonuçları sağlıklı Türk çocukları için belirlenmiş olan değerlerle karşılaştırıldı. Bulgular: Hastaların tamamında z skorları -2’den büyüktü, akut faz değerleri, kemik metabolizma belirteçleri normal sınırlar içinde bulundu. aBMD Z-skor ile demografik veriler, akut fazlar ve kemik metabolizma belirteçleri arasında korelasyon saptanmadı.Tanıda gecikme süresi ve BMD arasında negatif korelasyon saptandı. Sonuç: AAA’li çocuklarda aBMD Z-skorları normal olmakla birlikte tanıya geç başlanılan çocuklarda BMD daha düşük bulundu. Erken başlanan kolşisin tedavisi bu hastalarda optimal kemik sağlığı için önemlidir.

Keywords: Çocuk, inflamasyon, kemik mineral dansitesi

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APA

Atağ, E., Öcal Demir, S., & Ergüven, M. (2021). Evaluation of Bone Mineral Density in Prepubertal Children with Familial Mediterranean Fever. Journal of Child, 21(2), 89-93. https://doi.org/10.26650/jchild.2021.788750

AMA

Atağ E, Öcal Demir S, Ergüven M. Evaluation of Bone Mineral Density in Prepubertal Children with Familial Mediterranean Fever. Journal of Child. 2021;21(2):89-93. https://doi.org/10.26650/jchild.2021.788750

ABNT

Atağ, E.; Öcal Demir, S.; Ergüven, M. Evaluation of Bone Mineral Density in Prepubertal Children with Familial Mediterranean Fever. Journal of Child, [Publisher Location], v. 21, n. 2, p. 89-93, 2021.

Chicago: Author-Date Style

Atağ, Emine, and Sevliya Öcal Demir and Müferet Ergüven. 2021. “Evaluation of Bone Mineral Density in Prepubertal Children with Familial Mediterranean Fever.” Journal of Child 21, no. 2: 89-93. https://doi.org/10.26650/jchild.2021.788750

Chicago: Humanities Style

Atağ, Emine, and Sevliya Öcal Demir and Müferet Ergüven. “Evaluation of Bone Mineral Density in Prepubertal Children with Familial Mediterranean Fever.” Journal of Child 21, no. 2 (Dec. 2024): 89-93. https://doi.org/10.26650/jchild.2021.788750

Harvard: Australian Style

Atağ, E & Öcal Demir, S & Ergüven, M 2021, 'Evaluation of Bone Mineral Density in Prepubertal Children with Familial Mediterranean Fever', Journal of Child, vol. 21, no. 2, pp. 89-93, viewed 23 Dec. 2024, https://doi.org/10.26650/jchild.2021.788750

Harvard: Author-Date Style

Atağ, E. and Öcal Demir, S. and Ergüven, M. (2021) ‘Evaluation of Bone Mineral Density in Prepubertal Children with Familial Mediterranean Fever’, Journal of Child, 21(2), pp. 89-93. https://doi.org/10.26650/jchild.2021.788750 (23 Dec. 2024).

MLA

Atağ, Emine, and Sevliya Öcal Demir and Müferet Ergüven. “Evaluation of Bone Mineral Density in Prepubertal Children with Familial Mediterranean Fever.” Journal of Child, vol. 21, no. 2, 2021, pp. 89-93. [Database Container], https://doi.org/10.26650/jchild.2021.788750

Vancouver

Atağ E, Öcal Demir S, Ergüven M. Evaluation of Bone Mineral Density in Prepubertal Children with Familial Mediterranean Fever. Journal of Child [Internet]. 23 Dec. 2024 [cited 23 Dec. 2024];21(2):89-93. Available from: https://doi.org/10.26650/jchild.2021.788750 doi: 10.26650/jchild.2021.788750

ISNAD

Atağ, Emine - Öcal Demir, Sevliya - Ergüven, Müferet. “Evaluation of Bone Mineral Density in Prepubertal Children with Familial Mediterranean Fever”. Journal of Child 21/2 (Dec. 2024): 89-93. https://doi.org/10.26650/jchild.2021.788750

Volume 21, Issue 22021, P. 89-93

TIMELINE

Submitted	01.09.2020
Accepted	13.07.2021
Published Online	07.09.2021

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