Journal of Child

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Research Article


DOI :10.26650/jchild.2021.775736   IUP :10.26650/jchild.2021.775736    Full Text (PDF)

Fecal Calprotectin Levels in the Babies with Infantile Colic

Nalan Karabayır, Tülin Ayşe Özden, Özlem Durmaz, Emine Gülbin Gökçay

Objective: Excessive crying is one of the most common complaints in the first months of life. Although various theories have been proposed to explain infantile colic, the etiology is still unclear. The aim of this study is to measure fecal calprotectin levels in infants with and without infantile colic and to investigate their possible relationship with inflammation. Methods: Infants attending a General Pediatrics Clinic in Medipol Mega University Hospital constituted the study population. Fecal calprotectin levels were measured using the Elisa Method in a total of 70 infants aged 1-3 months, 35 of which had infantile colic. A total of 42 infants, 22 of whom were in the colic group and 20 of them in the control group were followed for one year. Results: The socio-demographic features and feeding types of the infants with or without infantile colic were similar. Fecal calprotectin levels were significantly higher in the colicky babies, and all had calprotectin levels > 250 µgr/g. The median fecal calprotectin values of the colic and control groups were 651 µgr/g and 354 µgr/g, respectively. No significant difference was found between the cases where the calprotectin levels were higher or lower than 350 µg/g in terms of birth weight, gender, mode of delivery, diet and use of probiotics. During the follow-up, symptoms of food allergy occurred in 4 patients in the control group and in 3 patients in the study group. Conclusion: High fecal calprotectin levels in the colic infants suggest that infantile colic and intestinal inflammation may be associated.

Keywords: Crying, calprotectin, infant, infantile colic, intestinal inflammation
DOI :10.26650/jchild.2021.775736   IUP :10.26650/jchild.2021.775736    Full Text (PDF)

İnfantil Kolikli Bebeklerde Dışkıda Kalprotektin Düzeyleri

Nalan Karabayır, Tülin Ayşe Özden, Özlem Durmaz, Emine Gülbin Gökçay

Amaç: Doğumu izleyen ilk üç ayda aşırı ağlama çok sık rastlanan bir yakınmadır. İnfantil kolik etyolojisi kesin olarak aydınlatılamamıştır. Son yıllarda intestinal mikrobiyatadaki değişikliklerin koliğe neden olabileceği ileri sürülmektedir. Çalışmamızın amacı dışkıda kalprotektin düzeylerinin ölçülerek kolik ile intestinal inflamasyon ilişkisinin araştırılmasıdır. Gereç ve Yöntem: Medipol Mega Üniversite hastanesi Genel Pediatri Polikliniğinde yapılan çalışmada 1-3 ay arası infantil kolikli 35 bebek (çalışma grubu) ile koliği olmayan 35 bebek olmak üzere toplam 70 bebeğin dışkıda kalprotektin düzeyleri İÜ Çocuk Gastroenteroloji Laboratuarında Elisa yöntemiyle ölçüldü. Kolik grubunda 22, kontrol grubunda 20 olmak üzere toplam 42 bebek bir yıl boyunca izlendi. Bulgular: Çalışma ve kontrol grubu bebekleri doğum tartısı, cins, doğum şekilleri, beslenme biçimleri açısından karşılaştırıldığında iki grup arasında fark saptanmadı. Çalışma grubunda kalprotektin düzeyleri anlamlı derecede yüksek olup, tüm olgularda fekal kalprotektin düzeyleri >250 µgr/g bulundu. Çalışma grubunun median kalprotektin değeri 651 µgr/g kontrol grubunun median değeri ise 354 µgr/g ölçüldü. Kalprotektin düzeyleri 350 µgr/g’den yüksek ve düşük olan olgular arasında doğum tartısı, cins, doğum şekli, beslenme biçimi ve probiyotik kullanımı açısından anlamlı fark saptanmadı. Takipte kontrol grubunda 4, çalışma grubunda 3 olgu besin alerjisi tanısı aldı. Sonuç: Kolik bebeklerde yüksek dışkı kalprotektin seviyeleri, infantil kolik ve intestinal inflamasyonun ilişkili olabileceğini düşündürmektedir.

Keywords: Ağlama, infantil kolik, intestinal enflamasyon, kalprotektin, süt çocuğu

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APA

Karabayır, N., Özden, T.A., Durmaz, Ö., & Gökçay, E.G. (2021). Fecal Calprotectin Levels in the Babies with Infantile Colic. Journal of Child, 21(2), 105-110. https://doi.org/10.26650/jchild.2021.775736


AMA

Karabayır N, Özden T A, Durmaz Ö, Gökçay E G. Fecal Calprotectin Levels in the Babies with Infantile Colic. Journal of Child. 2021;21(2):105-110. https://doi.org/10.26650/jchild.2021.775736


ABNT

Karabayır, N.; Özden, T.A.; Durmaz, Ö.; Gökçay, E.G. Fecal Calprotectin Levels in the Babies with Infantile Colic. Journal of Child, [Publisher Location], v. 21, n. 2, p. 105-110, 2021.


Chicago: Author-Date Style

Karabayır, Nalan, and Tülin Ayşe Özden and Özlem Durmaz and Emine Gülbin Gökçay. 2021. “Fecal Calprotectin Levels in the Babies with Infantile Colic.” Journal of Child 21, no. 2: 105-110. https://doi.org/10.26650/jchild.2021.775736


Chicago: Humanities Style

Karabayır, Nalan, and Tülin Ayşe Özden and Özlem Durmaz and Emine Gülbin Gökçay. “Fecal Calprotectin Levels in the Babies with Infantile Colic.” Journal of Child 21, no. 2 (Dec. 2024): 105-110. https://doi.org/10.26650/jchild.2021.775736


Harvard: Australian Style

Karabayır, N & Özden, TA & Durmaz, Ö & Gökçay, EG 2021, 'Fecal Calprotectin Levels in the Babies with Infantile Colic', Journal of Child, vol. 21, no. 2, pp. 105-110, viewed 23 Dec. 2024, https://doi.org/10.26650/jchild.2021.775736


Harvard: Author-Date Style

Karabayır, N. and Özden, T.A. and Durmaz, Ö. and Gökçay, E.G. (2021) ‘Fecal Calprotectin Levels in the Babies with Infantile Colic’, Journal of Child, 21(2), pp. 105-110. https://doi.org/10.26650/jchild.2021.775736 (23 Dec. 2024).


MLA

Karabayır, Nalan, and Tülin Ayşe Özden and Özlem Durmaz and Emine Gülbin Gökçay. “Fecal Calprotectin Levels in the Babies with Infantile Colic.” Journal of Child, vol. 21, no. 2, 2021, pp. 105-110. [Database Container], https://doi.org/10.26650/jchild.2021.775736


Vancouver

Karabayır N, Özden TA, Durmaz Ö, Gökçay EG. Fecal Calprotectin Levels in the Babies with Infantile Colic. Journal of Child [Internet]. 23 Dec. 2024 [cited 23 Dec. 2024];21(2):105-110. Available from: https://doi.org/10.26650/jchild.2021.775736 doi: 10.26650/jchild.2021.775736


ISNAD

Karabayır, Nalan - Özden, TülinAyşe - Durmaz, Özlem - Gökçay, EmineGülbin. “Fecal Calprotectin Levels in the Babies with Infantile Colic”. Journal of Child 21/2 (Dec. 2024): 105-110. https://doi.org/10.26650/jchild.2021.775736



TIMELINE


Submitted30.07.2020
Accepted13.07.2021
Published Online07.09.2021

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