Journal of Child

SUBMITINFORMATION
EnglishTürkçe

Research Article


DOI :10.26650/jchild.2021.2.853810   IUP :10.26650/jchild.2021.2.853810    Full Text (PDF)

A Study on Fungal Allergen Sensitization Rates Among Children with Allergic Rhinitis in the Southern Marmara Region

Muhittin Bodur, Yakup Canıtez, Şükrü Çekiç, Gökhan Ocakoğlu, Nihat Sapan

Objective: The aim of this study was to investigate the frequency of fungal allergen sensitivities and the factors associated with fungal allergen sensitivities in children with allergic rhinitis. Method: 331 children aged 2-18 years who were diagnosed with allergic rhinitis and had sensitivity to at least one inhalant allergen in skin prick tests were prospectively included in the study. The skin prick test was performed with standard allergen solutions. Results: 62.5% of the patients with allergic rhinitis were boys and 37.5% were girls, and the onset of symptoms was 6.77±4.06 years old. Mite sensitivity (68.8%) was the most common in children with allergic rhinitis, followed by grass pollen sensitivity (48.9%). Sensitivity to at least one fungal allergen was detected at a rate of 10.6% (n=35), the most common among this group being Alternaria alternata (88.5%). The age of onset of allergic rhinitis symptoms was found to be significantly earlier in the group with fungal allergen sensitivity compared to the group without fungal allergen sensitivity (5.23±3.44 years/6.95±4.09 years, respectively, p=0.019). For the presence of sensitivity to fungal allergens; Corylus avellena sensitivity or dog allergen sensitivity were found to be significant risk factors. In terms of additional asthma in patients with allergic rhinitis; Dermatophagoides farinae sensitivity or presence of cockroach sensitivity were found to be significant risk factors. Conclusion: Sensitivity to fungal allergens is observed at a remarkable rate in children with allergic rhinitis. Most of the sensitivity to fungal allergens is Alternaria alternata sensitivity.

Keywords: Allergic rhinitis, child, fungus, fungal sensitivity, allergen, sensitivity
DOI :10.26650/jchild.2021.2.853810   IUP :10.26650/jchild.2021.2.853810    Full Text (PDF)

Güney Marmara Bölgesindeki Alerjik Rinitli Çocuklarda Mantar Alerjenlerine Duyarlılık Oranlarının Araştırılması

Muhittin Bodur, Yakup Canıtez, Şükrü Çekiç, Gökhan Ocakoğlu, Nihat Sapan

Amaç: Alerjik rinit tanılı çocuklarda, mantar alerjen duyarlılıkları görülme sıklığını ve mantar alerjen duyarlılıkları ile ilişkili faktörlerin araştırılması amaçlanmıştır. Gereç ve Yöntem: Alerjik rinit tanılı ve deri prik testlerinde en az bir inhalan alerjene karşı duyarlılık saptanmış olan, 2-18 yaşlarında 331 çocuk olgu prospektif olarak çalışmaya alındı. Hastalara standart alerjen solusyonları ile deri prik testi yapıldı. Bulgular: Alerjik rinitli olguların %62,5’i erkek ve %37,5’i kız, semptomların başlangıç zamanı 6,77±4,06 yaş olarak saptandı. Alerjik rinitli çocuklarda en sık akar duyarlılığı (%68,8), ikinci sırada ise çimen polen duyarlılığı (%48,9) tespit edildi. En az bir mantar alerjenine karşı duyarlılık %10,6 (n=35) oranında saptandı, bu grup içinde en sık Alternaria alternata (%88,5) duyarlılığı saptandı. Mantar alerjeni duyarlılığı olan grupta mantar alerjeni duyarlılığı saptanmayan gruba göre alerjik rinit semptomlarının başlama yaşı anlamlı olarak daha erken saptandı (sırasıyla 5,23±3,44 yaş/6,95±4,09 yaş, p=0,019). Mantar alerjenleri duyarlılığı varlığı için; Corylus avellena duyarlılığının veya köpek alerjen duyarlılığının anlamlı risk faktörleri olduğu saptandı. Alerjik rinitli hastalarda ek olarak astım görülmesi açısından; Dermatofagoides farinae duyarlılığı veya hamam böceği duyarlılığı varlığının anlamlı risk faktörleri olduğu tespit edildi. Sonuç: Alerjik rinitli çocuklarda mantar alerjenlerine karşı duyarlılık, dikkate değer bir oranda görülmektedir. Mantar alerjenlerine duyarlılığın büyük kısmını Alternaria alternata duyarlılığı oluşturmaktadır.

Keywords: Alerjik rinit, alerjen, çocuk, duyarlılık, mantar, mantar duyarlılığı

PDF View

References

  • 1. Wallace DV, Dykewicz MS, Bernstein DI, Blessing-Moore J, Cox L, Khan DA, et al. The diagnosis and management of rhinitis: an updated practice parameter. J Allergy Clin Immunol 2008;122(2 suppl):1-84. google scholar
  • 2. Dykewicz MS, Wallace DV, Amrol DJ, Baroody FM, Bernstein JA, Craig TJ, et al. Rhinitis 2020: A practice parameter update. J Allergy Clin Immunol 2020;146(4):721-767. google scholar
  • 3. Meng Y, Wang C, Zhang L. Recent developments and highlights in allergic rhinitis. Allergy 2019;74:2320-8. google scholar
  • 4. Corsico R, Cinti B, Feliziani V, Gallesio MT, Liccardi G, Loreti A, et al. Prevalance of sensitization to alternaria in allergic patients in Italy. Ann Allergy Asthma Immunol 1998;80:71-6. google scholar
  • 5. Hocaoğlu AB, Karaman Ö. Çocukluk Çağında Allerjik Rinit- Derleme. Güncel Pediatri 2010;8:105-12. google scholar
  • 6. Dickerson PJK, Li J. Effects of damp and mould in the home on respiratory health: a review of the literature. Allergy 1998;53:120-8. google scholar
  • 7. Heinzerling L, Frew AJ, Bindslev-Jensen C, Bonini S, Bousquet J, Bresciani M, et al. Standard skin ptik testing and sensitization to inhalant allergens across Europe-a survey from the GA(2)LEN network. Allergy 2005;60:1287-300. google scholar
  • 8. Position paper: Allergen standardisation and skin tests. The European Academy of Allergology and Clinical Immunology. Allergy 1993;48:48-82. google scholar
  • 9. Gentile DA, Shapiro GG, Skoner DP. Allergic Rhinitis. Leung DYM, Sampson HA, Geha RS, Szefler, SJ editors. Pediatric Allergy: Principles and practice. Mosby-Year Book, Inc, St. Louis, MO. 2003:287-97. google scholar
  • 10. Wright AL, Holberg CJ, Martinez FD, Halonen M, Morgan W, Taussig LM. Epidemiology of physician-diagnosed allergic rhinitis in childhood. Pediatrics 1994;94:895-901. google scholar
  • 11. Harmancı K, Bakıtaş A, Türktaş İ. Sensitization to Aeroallergens in Preschool Children with Respiratory Problems in Ankara, Turkey. Turkish Respiratory Journal 2006;7(1):10-4. google scholar
  • 12. Yazicioglu M, Oner N, Cetlik C, Okutan O, Pala O. Sensitization to common allergens, especially pollens, among children with respiratory allergy in the Trakya region of Turkey. Asian Pac J Allergy Immunol 2004;22:183-90. google scholar
  • 13. Balatsouras DG, Koukoutsis G, Ganelis P, Fassolis A, Korres GS, Kaberos A. Study of Allergic Rhinitis in Childhood. Int J Otolaryngol 2011. doi:10.1155/2011/487532. google scholar
  • 14. Meltzer EO, Blaiss MS, Derebery MJ, Mahr TA, Gordon BR, Sheth KK, et al. Burden of allergic rhinitis: results from the Pediatric Allergies in America survey. J Allergy Clin Immunol 2009;124(suppl):S43-70. google scholar
  • 15. Lee JT, Lam ZCM, Lee WT, Kuo LC, Jayant V, Singh G, et al. Familial Risk of Allerjic Rhinitis and Atopic Dermatitis among Chinese Families in Singapore. Ann Acad Med Singapore 2004;33:71-4. google scholar
  • 16. Kidon MI, See Y, Goh A, Chay OM, Balakrishnan A. Aeroallergen sensitization in pediatric allergic rhinitis in Singapore: Is airconditioning a factor in the tropics? Pediatr Allergy Immunol 2004;15:340-3. google scholar
  • 17. Kidon MI, Chiang WC, Liew WK, Lim SH, See Y, Goh A, et al. Sensitization to dust mites in children with allergic rhinitis in Singapore: does it matter if you scratch while you sneeze? Clin Exp Allergy 2005;35:434-40. google scholar
  • 18. Bostancı I, Turktas I, Turkyılmaz C. Sensitization to aeroallergens in Ankara, Turkey. Allergy 1999;54:1328-36. google scholar
  • 19. Dold S, Wjst M, von Mutius E, Reitmeir P, Stiepel E. Genetic risk for asthma, alllergic rhinitis, and atopic dermatitis. Arch Dis Child 1992;67:1018-22. google scholar
  • 20. Sobki SH, Zakzouk SM. Point prevalence of allergic rhinitis among Saudi children. Rhinology 2004;42:137-40. google scholar
  • 21. Elmas B, Özdemir Ö. Sensitization Prevalence of Children with Allergic Rhinitis for Inhalant and Food Allergens in the Province of Sakarya, Turkey. JAREM 2017;7:63-9. google scholar
  • 22. Yazicioglu M, Oner N, Cetlik C, Okutan O, Pala O. Sensitization to common allergens, especially pollens, among children with respiratory allergy in the Trakya region of Turkey. Asian Pac J Allergy Immunol 2004;22:183-90. google scholar
  • 23. Harmancı K, Bakıtaş A, Türktaş İ. Sensitization to Aeroallergens in Preschool Children with Respiratory Problems in Ankara, Turkey. Turkish Respiratory Journal 2006;7(1):10-4. google scholar
  • 24. Bavbek S, Erkekol FO, Ceter T, Mungan D, Ozer F, Pinar M, et al. Sensitization to Alternaria and Cladosporium in patients with respiratory allergy and outdoor counts of mold spores in Ankara atmosphere, Turkey. J Asthma 2006;43(6):421-6. google scholar
  • 25. Moral L, Roig M, Gadre J, Alos A, Toral T, Fuentes MJ. Allergen sensitization in children with asthma and rhinitis: marked variations related to age and microgeographical factors. Allergol Immunopathol (Madr) 2008;36:128-33. google scholar
  • 26. Sritipsukho P. Aeroallergen Sensitivity Among Thai Children with Allergic Respiratory Disease:A Hospital-Based Study. Asian Pac J Allergy and Immunol 2004;22:91-5. google scholar
  • 27. Kidon MI, See Y, Goh A, Chay OM, Balakrishnan A. Aeroallergen sensitization in pediatric allergic rhinitis in Singapore: Is airconditioning a factor in the tropics? Pediatr Allergy Immunol 2004;15:340-3. google scholar
  • 28. Kidon MI, Chiang WC, Liew WK, Lim SH, See Y, Goh A, et al. Sensitization to dust mites in children with allergic rhinitis in Singapore: does it matter if you scratch while you sneeze? Clin Exp Allergy 2005;35:434-40. google scholar
  • 29. Yilmaz A, Tuncer A, Sekerel BE, Adalioglu G. Cockroach allergy in a group of Turkish children with respiratory allergies. Turk J Pediatr 2004;46:344-9. google scholar
  • 30. Küçükosmanoğlu E, Keskin Ö. Gaziantep’te Çocuklarda Solunum Allerjenleri Duyarlılığı. Astım Allerji İmmünoloji 2008;6:141-5. google scholar
  • 31. Codispoti CD, Bernstein DI, Levin L, Reponen T, Ryan PH, Biagini Myers JM, et al. Early-life mold and tree sensitivity is associated with allergic eosinophilicrhinitis at 4 years of age. Ann Allergy Asthma Immunol 2015;114(3):193-8. google scholar

Citations

Copy and paste a formatted citation or use one of the options to export in your chosen format


EXPORT



APA

Bodur, M., Canıtez, Y., Çekiç, Ş., Ocakoğlu, G., & Sapan, N. (2021). A Study on Fungal Allergen Sensitization Rates Among Children with Allergic Rhinitis in the Southern Marmara Region. Journal of Child, 21(2), 111-118. https://doi.org/10.26650/jchild.2021.2.853810


AMA

Bodur M, Canıtez Y, Çekiç Ş, Ocakoğlu G, Sapan N. A Study on Fungal Allergen Sensitization Rates Among Children with Allergic Rhinitis in the Southern Marmara Region. Journal of Child. 2021;21(2):111-118. https://doi.org/10.26650/jchild.2021.2.853810


ABNT

Bodur, M.; Canıtez, Y.; Çekiç, Ş.; Ocakoğlu, G.; Sapan, N. A Study on Fungal Allergen Sensitization Rates Among Children with Allergic Rhinitis in the Southern Marmara Region. Journal of Child, [Publisher Location], v. 21, n. 2, p. 111-118, 2021.


Chicago: Author-Date Style

Bodur, Muhittin, and Yakup Canıtez and Şükrü Çekiç and Gökhan Ocakoğlu and Nihat Sapan. 2021. “A Study on Fungal Allergen Sensitization Rates Among Children with Allergic Rhinitis in the Southern Marmara Region.” Journal of Child 21, no. 2: 111-118. https://doi.org/10.26650/jchild.2021.2.853810


Chicago: Humanities Style

Bodur, Muhittin, and Yakup Canıtez and Şükrü Çekiç and Gökhan Ocakoğlu and Nihat Sapan. “A Study on Fungal Allergen Sensitization Rates Among Children with Allergic Rhinitis in the Southern Marmara Region.” Journal of Child 21, no. 2 (Nov. 2024): 111-118. https://doi.org/10.26650/jchild.2021.2.853810


Harvard: Australian Style

Bodur, M & Canıtez, Y & Çekiç, Ş & Ocakoğlu, G & Sapan, N 2021, 'A Study on Fungal Allergen Sensitization Rates Among Children with Allergic Rhinitis in the Southern Marmara Region', Journal of Child, vol. 21, no. 2, pp. 111-118, viewed 15 Nov. 2024, https://doi.org/10.26650/jchild.2021.2.853810


Harvard: Author-Date Style

Bodur, M. and Canıtez, Y. and Çekiç, Ş. and Ocakoğlu, G. and Sapan, N. (2021) ‘A Study on Fungal Allergen Sensitization Rates Among Children with Allergic Rhinitis in the Southern Marmara Region’, Journal of Child, 21(2), pp. 111-118. https://doi.org/10.26650/jchild.2021.2.853810 (15 Nov. 2024).


MLA

Bodur, Muhittin, and Yakup Canıtez and Şükrü Çekiç and Gökhan Ocakoğlu and Nihat Sapan. “A Study on Fungal Allergen Sensitization Rates Among Children with Allergic Rhinitis in the Southern Marmara Region.” Journal of Child, vol. 21, no. 2, 2021, pp. 111-118. [Database Container], https://doi.org/10.26650/jchild.2021.2.853810


Vancouver

Bodur M, Canıtez Y, Çekiç Ş, Ocakoğlu G, Sapan N. A Study on Fungal Allergen Sensitization Rates Among Children with Allergic Rhinitis in the Southern Marmara Region. Journal of Child [Internet]. 15 Nov. 2024 [cited 15 Nov. 2024];21(2):111-118. Available from: https://doi.org/10.26650/jchild.2021.2.853810 doi: 10.26650/jchild.2021.2.853810


ISNAD

Bodur, Muhittin - Canıtez, Yakup - Çekiç, Şükrü - Ocakoğlu, Gökhan - Sapan, Nihat. “A Study on Fungal Allergen Sensitization Rates Among Children with Allergic Rhinitis in the Southern Marmara Region”. Journal of Child 21/2 (Nov. 2024): 111-118. https://doi.org/10.26650/jchild.2021.2.853810



TIMELINE


Submitted05.01.2021
Accepted27.07.2021
Published Online07.09.2021

LICENCE


Attribution-NonCommercial (CC BY-NC)

This license lets others remix, tweak, and build upon your work non-commercially, and although their new works must also acknowledge you and be non-commercial, they don’t have to license their derivative works on the same terms.


SHARE




Istanbul University Press aims to contribute to the dissemination of ever growing scientific knowledge through publication of high quality scientific journals and books in accordance with the international publishing standards and ethics. Istanbul University Press follows an open access, non-commercial, scholarly publishing.