Journal of Child

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DOI :10.5222/j.child.2013.011   IUP :10.5222/j.child.2013.011    Full Text (PDF)

Angiotensin Converting Enzyme Gene Polymorphism in Children with Henoch-Schonlein Purpura

Hasan Dursun, Aytül Noyan, Aysun Karabay Beyazıt, Selçuk Matyar, Mithat Büyükçelik, Behçet Şimsek, Gülen Atilla, Nurcan Cengiz, Ali Anarat

In conclusion these results does not support a statistically significantly association between renal involvement and DD genotype or D allel in children with HSP. However D allele was detected in 96 % patients and DD genotype was higher in patients with HSP nephritis than patients without renal involvement. According these results we showed that D allel is a facilitative and I allel is a protective factor for development and renal involvement of disease. However larger studies are required to confirm these results

Keywords: ACE gene polymorphism, Henoch-Schönlein purpura
DOI :10.5222/j.child.2013.011   IUP :10.5222/j.child.2013.011    Full Text (PDF)

Henoch-Schonlein Purpuralı Çocuklarda Angiotensin Konverting Enzim Gen Polimorfizmi

Hasan Dursun, Aytül Noyan, Aysun Karabay Beyazıt, Selçuk Matyar, Mithat Büyükçelik, Behçet Şimsek, Gülen Atilla, Nurcan Cengiz, Ali Anarat

Bu veriler HSP’li çocuklarda böbrek tutulumu ile DD genotipi veya D alleli arasında istatistiksel olarak anlamlı bir ilişkiyi desteklememektedir. Bununla birlikte D alleli hastaların % 96’sında saptandı ve DD genotipi de HSP nefritli hastalarda böbrek tutulumu olmayanlara göre daha yüksek bulundu. Bu sonuçlara göre hastalığın oluşumunda ve renal tutulumda D allelinin kolaylaştırıcı ve I allelinin ise koruyucu faktör olduğunu gösterdik, fakat bu bulguları destekleyen daha büyük çalışmalar gereklidir.

Keywords: ACE gen polimorfizmi, Henoch-Schönlein purpursı

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APA

Dursun, H., Noyan, A., Karabay Beyazıt, A., Matyar, S., Büyükçelik, M., Şimsek, B., Atilla, G., Cengiz, N., & Anarat, A. (2013). Angiotensin Converting Enzyme Gene Polymorphism in Children with Henoch-Schonlein Purpura. Journal of Child, 13(1), 11-15. https://doi.org/10.5222/j.child.2013.011


AMA

Dursun H, Noyan A, Karabay Beyazıt A, Matyar S, Büyükçelik M, Şimsek B, Atilla G, Cengiz N, Anarat A. Angiotensin Converting Enzyme Gene Polymorphism in Children with Henoch-Schonlein Purpura. Journal of Child. 2013;13(1):11-15. https://doi.org/10.5222/j.child.2013.011


ABNT

Dursun, H.; Noyan, A.; Karabay Beyazıt, A.; Matyar, S.; Büyükçelik, M.; Şimsek, B.; Atilla, G.; Cengiz, N.; Anarat, A. Angiotensin Converting Enzyme Gene Polymorphism in Children with Henoch-Schonlein Purpura. Journal of Child, [Publisher Location], v. 13, n. 1, p. 11-15, 2013.


Chicago: Author-Date Style

Dursun, Hasan, and Aytül Noyan and Aysun Karabay Beyazıt and Selçuk Matyar and Mithat Büyükçelik and Behçet Şimsek and Gülen Atilla and Nurcan Cengiz and Ali Anarat. 2013. “Angiotensin Converting Enzyme Gene Polymorphism in Children with Henoch-Schonlein Purpura.” Journal of Child 13, no. 1: 11-15. https://doi.org/10.5222/j.child.2013.011


Chicago: Humanities Style

Dursun, Hasan, and Aytül Noyan and Aysun Karabay Beyazıt and Selçuk Matyar and Mithat Büyükçelik and Behçet Şimsek and Gülen Atilla and Nurcan Cengiz and Ali Anarat. “Angiotensin Converting Enzyme Gene Polymorphism in Children with Henoch-Schonlein Purpura.” Journal of Child 13, no. 1 (Apr. 2025): 11-15. https://doi.org/10.5222/j.child.2013.011


Harvard: Australian Style

Dursun, H & Noyan, A & Karabay Beyazıt, A & Matyar, S & Büyükçelik, M & Şimsek, B & Atilla, G & Cengiz, N & Anarat, A 2013, 'Angiotensin Converting Enzyme Gene Polymorphism in Children with Henoch-Schonlein Purpura', Journal of Child, vol. 13, no. 1, pp. 11-15, viewed 4 Apr. 2025, https://doi.org/10.5222/j.child.2013.011


Harvard: Author-Date Style

Dursun, H. and Noyan, A. and Karabay Beyazıt, A. and Matyar, S. and Büyükçelik, M. and Şimsek, B. and Atilla, G. and Cengiz, N. and Anarat, A. (2013) ‘Angiotensin Converting Enzyme Gene Polymorphism in Children with Henoch-Schonlein Purpura’, Journal of Child, 13(1), pp. 11-15. https://doi.org/10.5222/j.child.2013.011 (4 Apr. 2025).


MLA

Dursun, Hasan, and Aytül Noyan and Aysun Karabay Beyazıt and Selçuk Matyar and Mithat Büyükçelik and Behçet Şimsek and Gülen Atilla and Nurcan Cengiz and Ali Anarat. “Angiotensin Converting Enzyme Gene Polymorphism in Children with Henoch-Schonlein Purpura.” Journal of Child, vol. 13, no. 1, 2013, pp. 11-15. [Database Container], https://doi.org/10.5222/j.child.2013.011


Vancouver

Dursun H, Noyan A, Karabay Beyazıt A, Matyar S, Büyükçelik M, Şimsek B, Atilla G, Cengiz N, Anarat A. Angiotensin Converting Enzyme Gene Polymorphism in Children with Henoch-Schonlein Purpura. Journal of Child [Internet]. 4 Apr. 2025 [cited 4 Apr. 2025];13(1):11-15. Available from: https://doi.org/10.5222/j.child.2013.011 doi: 10.5222/j.child.2013.011


ISNAD

Dursun, Hasan - Noyan, Aytül - Karabay Beyazıt, Aysun - Matyar, Selçuk - Büyükçelik, Mithat - Şimsek, Behçet - Atilla, Gülen - Cengiz, Nurcan - Anarat, Ali. “Angiotensin Converting Enzyme Gene Polymorphism in Children with Henoch-Schonlein Purpura”. Journal of Child 13/1 (Apr. 2025): 11-15. https://doi.org/10.5222/j.child.2013.011



TIMELINE


First Revision01.03.2013
Last Revision05.03.2013
Published Online30.03.2013

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