Journal of Child

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DOI :10.5222/j.child.2013.011   IUP :10.5222/j.child.2013.011    Full Text (PDF)

Henoch-Schonlein Purpuralı Çocuklarda Angiotensin Konverting Enzim Gen Polimorfizmi

Hasan Dursun, Aytül Noyan, Aysun Karabay Beyazıt, Selçuk Matyar, Mithat Büyükçelik, Behçet Şimsek, Gülen Atilla, Nurcan Cengiz, Ali Anarat

Bu veriler HSP’li çocuklarda böbrek tutulumu ile DD genotipi veya D alleli arasında istatistiksel olarak anlamlı bir ilişkiyi desteklememektedir. Bununla birlikte D alleli hastaların % 96’sında saptandı ve DD genotipi de HSP nefritli hastalarda böbrek tutulumu olmayanlara göre daha yüksek bulundu. Bu sonuçlara göre hastalığın oluşumunda ve renal tutulumda D allelinin kolaylaştırıcı ve I allelinin ise koruyucu faktör olduğunu gösterdik, fakat bu bulguları destekleyen daha büyük çalışmalar gereklidir.

Keywords: ACE gen polimorfizmi, Henoch-Schönlein purpursı
DOI :10.5222/j.child.2013.011   IUP :10.5222/j.child.2013.011    Full Text (PDF)

Angiotensin Converting Enzyme Gene Polymorphism in Children with Henoch-Schonlein Purpura

Hasan Dursun, Aytül Noyan, Aysun Karabay Beyazıt, Selçuk Matyar, Mithat Büyükçelik, Behçet Şimsek, Gülen Atilla, Nurcan Cengiz, Ali Anarat

In conclusion these results does not support a statistically significantly association between renal involvement and DD genotype or D allel in children with HSP. However D allele was detected in 96 % patients and DD genotype was higher in patients with HSP nephritis than patients without renal involvement. According these results we showed that D allel is a facilitative and I allel is a protective factor for development and renal involvement of disease. However larger studies are required to confirm these results

Keywords: ACE gene polymorphism, Henoch-Schönlein purpura

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References

  • Jennette JC, Falk RJ, Andrassy K, Bacon PA, Churg J, Gross WL, Hagen EC, et al. Nomenclature of systemic vas- culitides. Proposal of an international consensus conference. Arthritis Rheum 1994;37:187-92. http://dx.doi.org/10.1002/art.1780370206 PMid:8129773 google scholar
  • Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. An insertion deletion polymorphism in the angioten- sin I converting enzyme gene accounting for half of the variance of serum enzyme levels. J Clin Invest 1990;86:1343-6. http://dx.doi.org/10.1172/JCI114844 PMid:1976655 PMCid:296868 google scholar
  • Iwai N, Ohmichi N, Nakamura Y, Kinoshita M. DD genoty- pe of the angiotensin- converting enzyme gene is a risk factor for left ventricular hypertrophy. Circulation 1994;90:2622-8. http://dx.doi.org/10.1161/01.CIR.90.6.2622 PMid:7994801 google scholar
  • Dorria A, Warram JH, Krowlewski AS. Genetic predisposi- tion to diabetic nephropathy: evidence for a role of the angio- tensin I converting enzyme gene. Diabetes 1994;43:690-5. http://dx.doi.org/10.2337/diabetes.43.5.690 google scholar
  • Lee DY, Kim W, Kang SK, Koh GY, Park SK. Angiotensin- converting enzyme gene polymorphism in patients with mini- mal change nephrotic syndrome and focal segmental glomeru- losclerosis. Nephron 1997;77:471-3. http://dx.doi.org/10.1159/000190326 PMid:9434071 google scholar
  • harden PN, Geddes C, Rowe PA, McIlroy JH, Boulton-Jones M, Rodger RS. Polymorphisms in angiotensin- converting enzyme gene and progression of IgA nephropathy. Lancet 1995;345:1540-1.http://dx.doi.org/10.1016/S0140-6736(95)91088-3 google scholar
  • Tatsuma N, Asano T, Yoshida J, Ohashi R, Munakata E, Ambo K, Tsuchiya M. Angiotensin converting enzyme gene polymorphism with nephritis of Henoch-Schonlein purpura (abstract). Pediatr Nephrol 1998;12:C123. google scholar
  • Yoshioka T, Xu Y, Yoshida H, Shiraga H, Muraki T, Ito K. Deletion polymorphism of angiotensin converting enzyme gene predicts persistent proteinuria in Henoch-Schonlein pur- pura nephritis. Arch Dis Child 1998;79:394-9. http://dx.doi.org/10.1136/adc.79.5.394 PMid:10193250 PMCid:1717731 google scholar
  • Ozkaya O, Soylemezoglu O, Gonen S, Misirlioglu M, Tuncer S, Kalman S, Buyan N. Renin-angiotensin system gene polymorphisms: association with susceptibility to Henoch-Schonlein purpura and renal involvement. Clin Rheumatol 2006;25:861-5. http://dx.doi.org/10.1007/s10067-006-0207-4 PMid:16521052 google scholar
  • Amoroso A, Danek G, Vatta S, Crovella S, Berrino M, Guarrera S, Fasano ME, Coppo R and Behalf of the Italian Group of Renal Immunopathology. Polymorphism in angiotensin-converting enzyme gene and severity of renal disease in Henoch-Schonlein patients. Nephrol Dial Transplant 1998;13:3184-8. http://dx.doi.org/10.1093/ndt/13.12.3184 PMid:9870486 google scholar
  • Mills JA, Michel BA, Block D. The Americal College of Rheumatology 1990 criteria for the classification of Henoch- Schonlein Purpura. Arthritis Rheum 1990;33:1114-21.http://dx.doi.org/10.1002/art.1780330809 PMid:2202310 google scholar
  • Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1998;16:1215-20. http://dx.doi.org/10.1093/nar/16.3.1215 google scholar
  • Zee RY, Lou YK, Griffiths LR, Morris BJ. Association of a polymorphism of the angiotensin I-converting enzyme gene with essential hypertension. Biochem Biophys Res 184:9-15. google scholar
  • Haszon I, Friedman AL, Papp F, Bereczki C, Baji S, Bodrogi T. ACE gene polymorphism and renal scarring in primary vesicoureteric reflux. Pediatr Nephrol 2002;17: 1027-31. http://dx.doi.org/10.1007/s00467-002-0968-1 PMid:12478352 15. Hohenfellner K, Hunley TE, Brezinska R, Brodhag P, Shyr Y, Brenner W. ACE I/D gene polymorphism predicts renal damage in congenital uropathies. Pediatr Nephrol 1999;13: 514-8. http://dx.doi.org/10.1007/s004670050649 PMid:10452281 google scholar
  • Ozen S, Alikasifoglu M, Tuncbilek E, Bakkaloglu A, Besbas N, Aran B, Saatci U. Polymorphism in angiotensin converting enzyme gene and reflux nephropathy: a genetic predisposition to scar formation. Nephrol Dial Transplant 1997; 12:2031-2. http://dx.doi.org/10.1093/oxfordjournals.ndt.a027788 PMid:9306373 google scholar

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APA

Dursun, H., Noyan, A., Karabay Beyazıt, A., Matyar, S., Büyükçelik, M., Şimsek, B., Atilla, G., Cengiz, N., & Anarat, A. (2013). Henoch-Schonlein Purpuralı Çocuklarda Angiotensin Konverting Enzim Gen Polimorfizmi. Journal of Child, 13(1), 11-15. https://doi.org/10.5222/j.child.2013.011


AMA

Dursun H, Noyan A, Karabay Beyazıt A, Matyar S, Büyükçelik M, Şimsek B, Atilla G, Cengiz N, Anarat A. Henoch-Schonlein Purpuralı Çocuklarda Angiotensin Konverting Enzim Gen Polimorfizmi. Journal of Child. 2013;13(1):11-15. https://doi.org/10.5222/j.child.2013.011


ABNT

Dursun, H.; Noyan, A.; Karabay Beyazıt, A.; Matyar, S.; Büyükçelik, M.; Şimsek, B.; Atilla, G.; Cengiz, N.; Anarat, A. Henoch-Schonlein Purpuralı Çocuklarda Angiotensin Konverting Enzim Gen Polimorfizmi. Journal of Child, [Publisher Location], v. 13, n. 1, p. 11-15, 2013.


Chicago: Author-Date Style

Dursun, Hasan, and Aytül Noyan and Aysun Karabay Beyazıt and Selçuk Matyar and Mithat Büyükçelik and Behçet Şimsek and Gülen Atilla and Nurcan Cengiz and Ali Anarat. 2013. “Henoch-Schonlein Purpuralı Çocuklarda Angiotensin Konverting Enzim Gen Polimorfizmi.” Journal of Child 13, no. 1: 11-15. https://doi.org/10.5222/j.child.2013.011


Chicago: Humanities Style

Dursun, Hasan, and Aytül Noyan and Aysun Karabay Beyazıt and Selçuk Matyar and Mithat Büyükçelik and Behçet Şimsek and Gülen Atilla and Nurcan Cengiz and Ali Anarat. “Henoch-Schonlein Purpuralı Çocuklarda Angiotensin Konverting Enzim Gen Polimorfizmi.” Journal of Child 13, no. 1 (Apr. 2024): 11-15. https://doi.org/10.5222/j.child.2013.011


Harvard: Australian Style

Dursun, H & Noyan, A & Karabay Beyazıt, A & Matyar, S & Büyükçelik, M & Şimsek, B & Atilla, G & Cengiz, N & Anarat, A 2013, 'Henoch-Schonlein Purpuralı Çocuklarda Angiotensin Konverting Enzim Gen Polimorfizmi', Journal of Child, vol. 13, no. 1, pp. 11-15, viewed 23 Apr. 2024, https://doi.org/10.5222/j.child.2013.011


Harvard: Author-Date Style

Dursun, H. and Noyan, A. and Karabay Beyazıt, A. and Matyar, S. and Büyükçelik, M. and Şimsek, B. and Atilla, G. and Cengiz, N. and Anarat, A. (2013) ‘Henoch-Schonlein Purpuralı Çocuklarda Angiotensin Konverting Enzim Gen Polimorfizmi’, Journal of Child, 13(1), pp. 11-15. https://doi.org/10.5222/j.child.2013.011 (23 Apr. 2024).


MLA

Dursun, Hasan, and Aytül Noyan and Aysun Karabay Beyazıt and Selçuk Matyar and Mithat Büyükçelik and Behçet Şimsek and Gülen Atilla and Nurcan Cengiz and Ali Anarat. “Henoch-Schonlein Purpuralı Çocuklarda Angiotensin Konverting Enzim Gen Polimorfizmi.” Journal of Child, vol. 13, no. 1, 2013, pp. 11-15. [Database Container], https://doi.org/10.5222/j.child.2013.011


Vancouver

Dursun H, Noyan A, Karabay Beyazıt A, Matyar S, Büyükçelik M, Şimsek B, Atilla G, Cengiz N, Anarat A. Henoch-Schonlein Purpuralı Çocuklarda Angiotensin Konverting Enzim Gen Polimorfizmi. Journal of Child [Internet]. 23 Apr. 2024 [cited 23 Apr. 2024];13(1):11-15. Available from: https://doi.org/10.5222/j.child.2013.011 doi: 10.5222/j.child.2013.011


ISNAD

Dursun, Hasan - Noyan, Aytül - Karabay Beyazıt, Aysun - Matyar, Selçuk - Büyükçelik, Mithat - Şimsek, Behçet - Atilla, Gülen - Cengiz, Nurcan - Anarat, Ali. “Henoch-Schonlein Purpuralı Çocuklarda Angiotensin Konverting Enzim Gen Polimorfizmi”. Journal of Child 13/1 (Apr. 2024): 11-15. https://doi.org/10.5222/j.child.2013.011



TIMELINE


First Revision01.03.2013
Last Revision05.03.2013
Published Online30.03.2013

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