Evaluation of Patients with PCR-Positive Influenza Virus on Nasopharyngeal Specimens for Complications and Hospitalization

Sütçü Murat; Kara Manolya; Aktürk Hacer; Hançerli Törün Selda; Uysalol Metin; Meşe Sevim; Salman Nuran; Somer Ayper

doi:https://dx.doi.org/10.5222/j.child.2017.018

Research Article

DOI :10.5222/j.child.2017.018 IUP :10.5222/j.child.2017.018 Full Text (PDF)

Evaluation of Patients with PCR-Positive Influenza Virus on Nasopharyngeal Specimens for Complications and Hospitalization

Murat Sütçü, Manolya Kara, Hacer Aktürk, Selda Hançerli Törün, Metin Uysalol, Sevim Meşe, Nuran Salman, Ayper Somer

Objective: Influenza is usually an acute self-limiting disease, though it can cause serious complications in high-risk patients. In this study the patients diagnosed as influenza infection during the year 2014 were investigated, and evaluation of the differences between patients followed up on an outpatient basis, and those requiring hospitalization. Material and Method: Forty- eight patients diagnosed as influenza based on PCR- positive nasopharyngeal smears obtained from patients followed up as an inpatient or on an ambulatory basis according to their clinical status and hospitalized patients in Istanbul University, Faculty of Medicine, Department of Children’s Health and Diseases between January2014-December 2014 were included in the study. Patients’ medical records and laboratory analysis were retrospectively analyzed. Results: Median age of the patients (female, n=16, 33.3%) was 54 months (4-204 months). The median age of hospitalized patients [n=22, 45.8%, median 43.5 months, (4-204 months)] was statistically smaller than the median age of ambulatory patients [n=26, 54.2%, median 92.5 months, (4-204 months)] (p=0.002). Fever was the most common presenting symptom (n=38, 79,2%). Twenty-five patients (52.1%) had chronic diseases with the most common one being asthma (n=5, 10,4%). Only one patient (2.1%) had influenza vaccination. Influenza types were H1N1 (43,8%), H3N2 (27,1%) and Influenza B (n=14, 29,2%). Neutropenia was the most common pathologic laboratory finding (n=8, 16,7%). Median hemoglobin value of the hospitalized cases [median 11,7 gr/dL (7,4-1,3 gr/dL)] was significantly lower than that of the patients followed up on an ambulatory basis [median 12,4 gr/dL, (9,9-14,6 gr/ dL)] (p=0,02). In total, median duration of the disease was 10 days (7-21 days). A patient (2,1%) with the diagnosis of chronic liver disease died secondary to acute respiratory distress syndrome. Conclusion: In order to decrease complications and hospitalization rates related to influenza, small children and the patients with chronic disorders should be vaccinated.

Keywords: Influenza, child, complication

DOI :10.5222/j.child.2017.018 IUP :10.5222/j.child.2017.018 Full Text (PDF)

Nazofarengeal Sürüntü Örneklerinde PCR ile İnfluenza Virüsü Saptanan Vakaların Hastane Yatışı ve Komplikasyon Gelişimi Açısından Değerlendirilmesi

Murat Sütçü, Manolya Kara, Hacer Aktürk, Selda Hançerli Törün, Metin Uysalol, Sevim Meşe, Nuran Salman, Ayper Somer

Amaç: İnfluenza; sıklıkla akut, kendini sınırlayan bir hastalık olmakla birlikte, özellikle risk grubundaki hastalarda komplikasyonlarla seyredebilmektedir. Çalışmamızda 2014 yılı boyunca influenza tanısı alan vakalar incelenmiş ve ayaktan izlenen hastalar ile hastane yatışı gerektiren vakalar arasındaki farkların değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Çalışmaya, İstanbul Tıp Fakültesi Çocuk Sağlığı ve Hastalıkları Kliniği’nde Ocak-Aralık 2014 tarihlerinde, nazofarengeal sürüntü örneklerinde PCR inceleme ile influenza tanısı alan ve klinik durumuna göre ayaktan ya da yatarak izlenen 48 çocuk vaka dahil edildi. Hasta dosyaları, laboratuvar tetkikleri ve epikrizleri retrospektif olarak incelendi. Bulgular: İnfluenza tanılı 48 hastanın (kız, n=16, %33.3) yaş ortalaması 54 ay (4-204 ay) idi. Hastaneye yatırılan hastaların (n=22, %45.8) ortalama yaşı [ortanca 43.5 ay, (4-204 ay)], ayaktan izlenen hastaların (n=26, %54.2) ortalama yaşından [ortanca 92.5 ay, (4-204 ay)] anlamlı olarak küçük bulundu (p=0.002). En sık kliniğe başvuru yakınması ateşti (n=38, %79.2). Hastaların %52.1’inde (n=25), başta astım (n=5, %10.4) olmak üzere eşlik eden kronik hastalık mevcuttu. Yalnızca 1 hasta (%2.1) aşılanmıştı. Yirmi bir hastada (%43.8) H1N1, 13 hastada (%27.1) H3N2 ve 14 hastada (%29.2) İnfluenza B virüsü tespit edildi. En sık laboratuvar bulgusu nötropeni (n=8, %16.7) idi. Hastaneye yatırılan vakaların ortalama hemoglobin düzeyi [ortanca 11.7 gr/dL (7.4-13 gr/dL)] ayaktan izlenen hastalara göre [ortanca 12.4 gr/dL, (9.9-14.6 g/dL)] anlamlı ölçüde düşük bulundu (p=0.02). Tüm hastalarda ortalama hastalık süresi 10 gün (7-21 gün) idi. Kronik karaciğer hastalığı olan bir vaka (%2.1) ARDS nedeniyle kaybedildi. Sonuç: İnfluenzaya bağlı komplikasyonların ve hastane yatış oranlarının azaltılabilmesi için küçük yaştaki çocuklar ile kronik hastalığı olan vakalar aşılanmalıdır

Keywords: İnfluenza, çocuk, komplikasyon

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APA

Sütçü, M., Kara, M., Aktürk, H., Hançerli Törün, S., Uysalol, M., Meşe, S., Salman, N., & Somer, A. (0001). Evaluation of Patients with PCR-Positive Influenza Virus on Nasopharyngeal Specimens for Complications and Hospitalization. Journal of Child, 17(1), 18-23. https://doi.org/10.5222/j.child.2017.018

AMA

Sütçü M, Kara M, Aktürk H, Hançerli Törün S, Uysalol M, Meşe S, Salman N, Somer A. Evaluation of Patients with PCR-Positive Influenza Virus on Nasopharyngeal Specimens for Complications and Hospitalization. Journal of Child. 0001;17(1):18-23. https://doi.org/10.5222/j.child.2017.018

ABNT

Sütçü, M.; Kara, M.; Aktürk, H.; Hançerli Törün, S.; Uysalol, M.; Meşe, S.; Salman, N.; Somer, A. Evaluation of Patients with PCR-Positive Influenza Virus on Nasopharyngeal Specimens for Complications and Hospitalization. Journal of Child, [Publisher Location], v. 17, n. 1, p. 18-23, 0001.

Chicago: Author-Date Style

Sütçü, Murat, and Manolya Kara and Hacer Aktürk and Selda Hançerli Törün and Metin Uysalol and Sevim Meşe and Nuran Salman and Ayper Somer. 0001. “Evaluation of Patients with PCR-Positive Influenza Virus on Nasopharyngeal Specimens for Complications and Hospitalization.” Journal of Child 17, no. 1: 18-23. https://doi.org/10.5222/j.child.2017.018

Chicago: Humanities Style

Sütçü, Murat, and Manolya Kara and Hacer Aktürk and Selda Hançerli Törün and Metin Uysalol and Sevim Meşe and Nuran Salman and Ayper Somer. “Evaluation of Patients with PCR-Positive Influenza Virus on Nasopharyngeal Specimens for Complications and Hospitalization.” Journal of Child 17, no. 1 (Nov. 2024): 18-23. https://doi.org/10.5222/j.child.2017.018

Harvard: Australian Style

Sütçü, M & Kara, M & Aktürk, H & Hançerli Törün, S & Uysalol, M & Meşe, S & Salman, N & Somer, A 0001, 'Evaluation of Patients with PCR-Positive Influenza Virus on Nasopharyngeal Specimens for Complications and Hospitalization', Journal of Child, vol. 17, no. 1, pp. 18-23, viewed 25 Nov. 2024, https://doi.org/10.5222/j.child.2017.018

Harvard: Author-Date Style

Sütçü, M. and Kara, M. and Aktürk, H. and Hançerli Törün, S. and Uysalol, M. and Meşe, S. and Salman, N. and Somer, A. (0001) ‘Evaluation of Patients with PCR-Positive Influenza Virus on Nasopharyngeal Specimens for Complications and Hospitalization’, Journal of Child, 17(1), pp. 18-23. https://doi.org/10.5222/j.child.2017.018 (25 Nov. 2024).

MLA

Sütçü, Murat, and Manolya Kara and Hacer Aktürk and Selda Hançerli Törün and Metin Uysalol and Sevim Meşe and Nuran Salman and Ayper Somer. “Evaluation of Patients with PCR-Positive Influenza Virus on Nasopharyngeal Specimens for Complications and Hospitalization.” Journal of Child, vol. 17, no. 1, 0001, pp. 18-23. [Database Container], https://doi.org/10.5222/j.child.2017.018

Vancouver

Sütçü M, Kara M, Aktürk H, Hançerli Törün S, Uysalol M, Meşe S, Salman N, Somer A. Evaluation of Patients with PCR-Positive Influenza Virus on Nasopharyngeal Specimens for Complications and Hospitalization. Journal of Child [Internet]. 25 Nov. 2024 [cited 25 Nov. 2024];17(1):18-23. Available from: https://doi.org/10.5222/j.child.2017.018 doi: 10.5222/j.child.2017.018

ISNAD

Sütçü, Murat - Kara, Manolya - Aktürk, Hacer - Hançerli Törün, Selda - Uysalol, Metin - Meşe, Sevim - Salman, Nuran - Somer, Ayper. “Evaluation of Patients with PCR-Positive Influenza Virus on Nasopharyngeal Specimens for Complications and Hospitalization”. Journal of Child 17/1 (Nov. 2024): 18-23. https://doi.org/10.5222/j.child.2017.018

Volume 17, Issue 12017, P. 18-23

TIMELINE

Submitted	27.06.2016
Accepted	27.07.2016

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Journal of Child

Research Article

Evaluation of Patients with PCR-Positive Influenza Virus on Nasopharyngeal Specimens for Complications and Hospitalization

Nazofarengeal Sürüntü Örneklerinde PCR ile İnfluenza Virüsü Saptanan Vakaların Hastane Yatışı ve Komplikasyon Gelişimi Açısından Değerlendirilmesi

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