Research Article


DOI :10.26650/jchild.2024.1352861   IUP :10.26650/jchild.2024.1352861    Full Text (PDF)

Pregnancy in Patients with Thalassemia: A Single-Center Study

Selime AydoğduBegüm Şirin KoçŞifa ŞahinSimge ErdemSerap KaramanZeynep Karakaş

Objective: In thalassemia syndromes, iron accumulation due to transfusion or excessive iron absorption adversely affects many organ functions, including the endocrine system. Due to advances in effective transfusion and chelation therapy in recent years a significant increase as occured in the life expectancy and quality of life of patients. This situation has also led to an increase in patients’ expectation of having children.

Methods: This study retrospectively, evaluates the transfusion characteristics, complications and conditions of the babies with regard to pre-pregnancy, pregnancy and delivery of our transfusion-dependent thalassemia patients who’ve had children and were monitored at the Istanbul University Medical Faculty, Department of Pediatric Hematology and Oncology.

Results: The study includes 15 patients with a gestational age between 22-34 (28±3,9) years, five with thalassemia major, nine with thalassemia intermedia, and one with thalassemia trait and alpha triplication. While 14 patients came for regular follow-ups, one did not. The patients on a regular transfusion program had an increased frequency of transfusions throughout pregnancy; four patients with thalassemia intermedia, who had never undergone a transfusion before, were observed to have been included in a regular transfusion program starting with the 2nd trimester of pregnancy. None of the patients developed cardiac and/or thromboembolic complications. One patient diagnosed with thalassemia intermedia and one patient diagnosed with thalassemia major each had a stillborn baby, three patients diagnosed with thalassemia intermedia had preterm babies and four other patients had babies with intrauterine growth restrictions (IUGR).

Conclusions: Thalassemia patients who are followed up with a regular multidisciplinary approach will be able to have a healthy pregnancy and children through the early recognition, prevention and treatment of complications.


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APA

Aydoğdu, S., Şirin Koç, B., Şahin, Ş., Erdem, S., Karaman, S., & Karakaş, Z. (2024). Pregnancy in Patients with Thalassemia: A Single-Center Study. Journal of Child, 24(1), 25-29. https://doi.org/10.26650/jchild.2024.1352861


AMA

Aydoğdu S, Şirin Koç B, Şahin Ş, Erdem S, Karaman S, Karakaş Z. Pregnancy in Patients with Thalassemia: A Single-Center Study. Journal of Child. 2024;24(1):25-29. https://doi.org/10.26650/jchild.2024.1352861


ABNT

Aydoğdu, S.; Şirin Koç, B.; Şahin, Ş.; Erdem, S.; Karaman, S.; Karakaş, Z. Pregnancy in Patients with Thalassemia: A Single-Center Study. Journal of Child, [Publisher Location], v. 24, n. 1, p. 25-29, 2024.


Chicago: Author-Date Style

Aydoğdu, Selime, and Begüm Şirin Koç and Şifa Şahin and Simge Erdem and Serap Karaman and Zeynep Karakaş. 2024. “Pregnancy in Patients with Thalassemia: A Single-Center Study.” Journal of Child 24, no. 1: 25-29. https://doi.org/10.26650/jchild.2024.1352861


Chicago: Humanities Style

Aydoğdu, Selime, and Begüm Şirin Koç and Şifa Şahin and Simge Erdem and Serap Karaman and Zeynep Karakaş. Pregnancy in Patients with Thalassemia: A Single-Center Study.” Journal of Child 24, no. 1 (Sep. 2024): 25-29. https://doi.org/10.26650/jchild.2024.1352861


Harvard: Australian Style

Aydoğdu, S & Şirin Koç, B & Şahin, Ş & Erdem, S & Karaman, S & Karakaş, Z 2024, 'Pregnancy in Patients with Thalassemia: A Single-Center Study', Journal of Child, vol. 24, no. 1, pp. 25-29, viewed 8 Sep. 2024, https://doi.org/10.26650/jchild.2024.1352861


Harvard: Author-Date Style

Aydoğdu, S. and Şirin Koç, B. and Şahin, Ş. and Erdem, S. and Karaman, S. and Karakaş, Z. (2024) ‘Pregnancy in Patients with Thalassemia: A Single-Center Study’, Journal of Child, 24(1), pp. 25-29. https://doi.org/10.26650/jchild.2024.1352861 (8 Sep. 2024).


MLA

Aydoğdu, Selime, and Begüm Şirin Koç and Şifa Şahin and Simge Erdem and Serap Karaman and Zeynep Karakaş. Pregnancy in Patients with Thalassemia: A Single-Center Study.” Journal of Child, vol. 24, no. 1, 2024, pp. 25-29. [Database Container], https://doi.org/10.26650/jchild.2024.1352861


Vancouver

Aydoğdu S, Şirin Koç B, Şahin Ş, Erdem S, Karaman S, Karakaş Z. Pregnancy in Patients with Thalassemia: A Single-Center Study. Journal of Child [Internet]. 8 Sep. 2024 [cited 8 Sep. 2024];24(1):25-29. Available from: https://doi.org/10.26650/jchild.2024.1352861 doi: 10.26650/jchild.2024.1352861


ISNAD

Aydoğdu, Selime - Şirin Koç, Begüm - Şahin, Şifa - Erdem, Simge - Karaman, Serap - Karakaş, Zeynep. Pregnancy in Patients with Thalassemia: A Single-Center Study”. Journal of Child 24/1 (Sep. 2024): 25-29. https://doi.org/10.26650/jchild.2024.1352861



TIMELINE


Submitted05.09.2023
Accepted29.11.2023
Published Online07.05.2024

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