Journal of Child

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DOI :10.26650/jchild.2023.1324273   IUP :10.26650/jchild.2023.1324273    Full Text (PDF)

Rhabdomyosarcoma in the Oral Cavity of A Pediatric Patient: A Rare Case

Betül Şimşek, Esin Doğan, Didar Gürsoy Kuzuluk, Mustafa Cemaloğlu

Dear Editor,

Rhabdomyosarcoma (RMS) is a rare, aggressive, and malignant neoplasm with rapid growth composed of primitive mesenchymal cells that exhibit skeletal muscle differentiation and mainly affects children and adolescents (60%) [1]. RMS is the most common soft tissue sarcoma with a rate of 50-60% in pediatric patients and ranks third among pediatric extracranial solid tumors, following Wilms tumor and neuroblastoma at a rate of 4-5% [2]. Head and neck localizations constitute 35–40% of cases, with oral lesions being extremely rare [3].

RMS has four well-defined subtypes: embryonal, alveolar, spindle cell/sclerosing, and pleomorphic. Embryonal RMS comprises 70-75% of all RMS cases [4], which are mostly sporadic. However, an increase has occurred in the number of recent studies on RMS, and the conclusions of these studies have shown that the children detected with defects in the RAS or Hedgehog pathways, as well as those with predisposing familial syndromes, carry a higher risk for developing embryonal RMS. In addition, PAX3-FOX01 and PAX7-FOXO1 fusions have been identified in alveolar RMS and been accepted as diagnostic markers by many researchers [4-7].

The literature describes the clinical signs and symptoms of oral RMS as rapidly growing swelling, facial asymmetry, paresthesia, trismus, and difficulty swallowing [1,8].

Keywords: Rhabdomyosarcoma, pathology, oncology, pediatrics

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References

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APA

Şimşek, B., Doğan, E., Gürsoy Kuzuluk, D., & Cemaloğlu, M. (2023). Rhabdomyosarcoma in the Oral Cavity of A Pediatric Patient: A Rare Case. Journal of Child, 23(4), 399-400. https://doi.org/10.26650/jchild.2023.1324273


AMA

Şimşek B, Doğan E, Gürsoy Kuzuluk D, Cemaloğlu M. Rhabdomyosarcoma in the Oral Cavity of A Pediatric Patient: A Rare Case. Journal of Child. 2023;23(4):399-400. https://doi.org/10.26650/jchild.2023.1324273


ABNT

Şimşek, B.; Doğan, E.; Gürsoy Kuzuluk, D.; Cemaloğlu, M. Rhabdomyosarcoma in the Oral Cavity of A Pediatric Patient: A Rare Case. Journal of Child, [Publisher Location], v. 23, n. 4, p. 399-400, 2023.


Chicago: Author-Date Style

Şimşek, Betül, and Esin Doğan and Didar Gürsoy Kuzuluk and Mustafa Cemaloğlu. 2023. “Rhabdomyosarcoma in the Oral Cavity of A Pediatric Patient: A Rare Case.” Journal of Child 23, no. 4: 399-400. https://doi.org/10.26650/jchild.2023.1324273


Chicago: Humanities Style

Şimşek, Betül, and Esin Doğan and Didar Gürsoy Kuzuluk and Mustafa Cemaloğlu. “Rhabdomyosarcoma in the Oral Cavity of A Pediatric Patient: A Rare Case.” Journal of Child 23, no. 4 (May. 2024): 399-400. https://doi.org/10.26650/jchild.2023.1324273


Harvard: Australian Style

Şimşek, B & Doğan, E & Gürsoy Kuzuluk, D & Cemaloğlu, M 2023, 'Rhabdomyosarcoma in the Oral Cavity of A Pediatric Patient: A Rare Case', Journal of Child, vol. 23, no. 4, pp. 399-400, viewed 2 May. 2024, https://doi.org/10.26650/jchild.2023.1324273


Harvard: Author-Date Style

Şimşek, B. and Doğan, E. and Gürsoy Kuzuluk, D. and Cemaloğlu, M. (2023) ‘Rhabdomyosarcoma in the Oral Cavity of A Pediatric Patient: A Rare Case’, Journal of Child, 23(4), pp. 399-400. https://doi.org/10.26650/jchild.2023.1324273 (2 May. 2024).


MLA

Şimşek, Betül, and Esin Doğan and Didar Gürsoy Kuzuluk and Mustafa Cemaloğlu. “Rhabdomyosarcoma in the Oral Cavity of A Pediatric Patient: A Rare Case.” Journal of Child, vol. 23, no. 4, 2023, pp. 399-400. [Database Container], https://doi.org/10.26650/jchild.2023.1324273


Vancouver

Şimşek B, Doğan E, Gürsoy Kuzuluk D, Cemaloğlu M. Rhabdomyosarcoma in the Oral Cavity of A Pediatric Patient: A Rare Case. Journal of Child [Internet]. 2 May. 2024 [cited 2 May. 2024];23(4):399-400. Available from: https://doi.org/10.26650/jchild.2023.1324273 doi: 10.26650/jchild.2023.1324273


ISNAD

Şimşek, Betül - Doğan, Esin - Gürsoy Kuzuluk, Didar - Cemaloğlu, Mustafa. “Rhabdomyosarcoma in the Oral Cavity of A Pediatric Patient: A Rare Case”. Journal of Child 23/4 (May. 2024): 399-400. https://doi.org/10.26650/jchild.2023.1324273



TIMELINE


Submitted07.07.2023
Accepted08.11.2023
Published Online20.12.2023

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