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DOI :10.26650/IUITFD.1389716   IUP :10.26650/IUITFD.1389716    Full Text (PDF)

DOPPLER INDICES AND PERINATAL OUTCOMES IN FETUSES WITH EBSTEIN’S ANOMALY

Özge Kahramanoğlu, Oya Demirci, Lütfiye Uygur, Aydın Öcal

Objective: Ebstein’s anomaly (EA) is a rare congenital malformation associated with high perinatal mortality. In this study, we aimed to assess perinatal outcomes and factors associated with mortality in fetuses with EA.

Material and Method: In this study, fetuses diagnosed with EA from 2016 to 2022 were included. Clinical information, ultrasonographic findings, and Doppler parameters were collected retrospectively.

Result: A total of 14 fetuses with EA were included. Twelve patients had isolated EA, while one had unilateral renal agenesis and the other had mega cisterna magna. Amniocentesis was performed in six cases and normal results were obtained. Nine fetuses reached term pregnancy. All fetuses survived to birth. Three cases died in the first week after birth. Survivors were found to have lower tricuspid valve annulus diameter z score when compared with non-survivors (4.81±3.05 vs 6.97±1.26, respectively, p=0.05). Reversal pulmonary artery flow (2/11 vs 4/4 in survivors and non-survivors, respectively, p=0.01) and pulmonary atresia (1/11 vs 4/4 in survivors and non-survivors, respectively, p<0.01) were significantly more frequent in non-survivors.

Conclusion: Perinatal mortality remains high in EA. Higher tricuspid valve annulus diameter z score, presence of reversal pulmonary artery flow, and pulmonary atresia during prenatal diagnosis are associated with poorer diagnosis. Future multicenter studies are warranted to identify risk factors and guide perinatal management. 

Keywords: Doppler, echocardiography, ultrasonography, Ebstein’s anomaly
DOI :10.26650/IUITFD.1389716   IUP :10.26650/IUITFD.1389716    Full Text (PDF)

EBSTEİN ANOMALİLİ FETÜSLERDE DOPPLER İNDEKSLERİ VE PERİNATAL SONUÇLAR

Özge Kahramanoğlu, Oya Demirci, Lütfiye Uygur, Aydın Öcal

Amaç: Ebstein anomalisi (EA) yüksek perinatal mortalite ile ilişkili nadir bir konjenital malformasyondur. Bu çalışmada, EA'lı fetüslerde perinatal sonuçları ve mortalite ile ilişkili faktörleri değerlendirme amaçlandı.

Gereç ve Yöntem: Bu çalışmaya, 2016-2022 yılları arasında EA tanısı alan fetüsler çalışmaya dahil edilmiştir. Klinik bilgiler, ultrasonografik bulgular ve Doppler parametreleri retrospektif olarak toplandı.

Bulgular: EA'lı toplam 14 fetüs çalışmaya dahil edildi. On iki hastada izole EA, birinde tek taraflı renal agenezi ve diğerinde mega sisterna magna vardı. Amniyosentez altı olguda yapıldı ve normal sonuçlar elde edildi. Dokuz fetüs term gebeliğe ulaştı. Tüm fetüsler doğuma kadar hayatta kaldı. Üç olgu doğumdan sonraki ilk hafta içinde kaybedildi. Hayatta kalanların triküspit kapak anulus çapı z skoru hayatta kalmayanlara göre daha düşük bulundu (sırasıyla 4,81±3,05 vs 6,97±1,26, p=0,05). Pulmoner arterde ters akım (hayatta kalanlarda ve hayatta kalmayanlarda sırasıyla 2/11 vs 4/4, p=0,01) ve pulmoner atrezi (hayatta kalanlarda ve hayatta kalmayanlarda sırasıyla 1/11 vs 4/4, p<0,01) hayatta kalmayanlarda anlamlı olarak daha sıktı.

Sonuç: EA'da perinatal mortalite hala yüksektir. Prenatal tanı sırasında daha yüksek triküspit kapak anulus çapı z skoru, pulmoner arterde ters akım ve pulmoner atrezi varlığı daha kötü prognoz ile ilişkilidir. Risk faktörlerini belirlemek ve perinatal dönemi yönetmek için gelecekte yapılacak çok merkezli çalışmalara ihtiyaç vardır.

Keywords: Doppler, ekokardiyografi, ultrasonografi, Ebstein anomalisi

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APA

Kahramanoğlu, Ö., Demirci, O., Uygur, L., & Öcal, A. (2024). DOPPLER INDICES AND PERINATAL OUTCOMES IN FETUSES WITH EBSTEIN’S ANOMALY. Journal of Istanbul Faculty of Medicine, 87(2), 134-138. https://doi.org/10.26650/IUITFD.1389716


AMA

Kahramanoğlu Ö, Demirci O, Uygur L, Öcal A. DOPPLER INDICES AND PERINATAL OUTCOMES IN FETUSES WITH EBSTEIN’S ANOMALY. Journal of Istanbul Faculty of Medicine. 2024;87(2):134-138. https://doi.org/10.26650/IUITFD.1389716


ABNT

Kahramanoğlu, Ö.; Demirci, O.; Uygur, L.; Öcal, A. DOPPLER INDICES AND PERINATAL OUTCOMES IN FETUSES WITH EBSTEIN’S ANOMALY. Journal of Istanbul Faculty of Medicine, [Publisher Location], v. 87, n. 2, p. 134-138, 2024.


Chicago: Author-Date Style

Kahramanoğlu, Özge, and Oya Demirci and Lütfiye Uygur and Aydın Öcal. 2024. “DOPPLER INDICES AND PERINATAL OUTCOMES IN FETUSES WITH EBSTEIN’S ANOMALY.” Journal of Istanbul Faculty of Medicine 87, no. 2: 134-138. https://doi.org/10.26650/IUITFD.1389716


Chicago: Humanities Style

Kahramanoğlu, Özge, and Oya Demirci and Lütfiye Uygur and Aydın Öcal. “DOPPLER INDICES AND PERINATAL OUTCOMES IN FETUSES WITH EBSTEIN’S ANOMALY.” Journal of Istanbul Faculty of Medicine 87, no. 2 (Nov. 2024): 134-138. https://doi.org/10.26650/IUITFD.1389716


Harvard: Australian Style

Kahramanoğlu, Ö & Demirci, O & Uygur, L & Öcal, A 2024, 'DOPPLER INDICES AND PERINATAL OUTCOMES IN FETUSES WITH EBSTEIN’S ANOMALY', Journal of Istanbul Faculty of Medicine, vol. 87, no. 2, pp. 134-138, viewed 15 Nov. 2024, https://doi.org/10.26650/IUITFD.1389716


Harvard: Author-Date Style

Kahramanoğlu, Ö. and Demirci, O. and Uygur, L. and Öcal, A. (2024) ‘DOPPLER INDICES AND PERINATAL OUTCOMES IN FETUSES WITH EBSTEIN’S ANOMALY’, Journal of Istanbul Faculty of Medicine, 87(2), pp. 134-138. https://doi.org/10.26650/IUITFD.1389716 (15 Nov. 2024).


MLA

Kahramanoğlu, Özge, and Oya Demirci and Lütfiye Uygur and Aydın Öcal. “DOPPLER INDICES AND PERINATAL OUTCOMES IN FETUSES WITH EBSTEIN’S ANOMALY.” Journal of Istanbul Faculty of Medicine, vol. 87, no. 2, 2024, pp. 134-138. [Database Container], https://doi.org/10.26650/IUITFD.1389716


Vancouver

Kahramanoğlu Ö, Demirci O, Uygur L, Öcal A. DOPPLER INDICES AND PERINATAL OUTCOMES IN FETUSES WITH EBSTEIN’S ANOMALY. Journal of Istanbul Faculty of Medicine [Internet]. 15 Nov. 2024 [cited 15 Nov. 2024];87(2):134-138. Available from: https://doi.org/10.26650/IUITFD.1389716 doi: 10.26650/IUITFD.1389716


ISNAD

Kahramanoğlu, Özge - Demirci, Oya - Uygur, Lütfiye - Öcal, Aydın. “DOPPLER INDICES AND PERINATAL OUTCOMES IN FETUSES WITH EBSTEIN’S ANOMALY”. Journal of Istanbul Faculty of Medicine 87/2 (Nov. 2024): 134-138. https://doi.org/10.26650/IUITFD.1389716



TIMELINE


Submitted13.11.2023
Accepted16.01.2024
Published Online09.02.2024

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