Case Report


DOI :https://doi.org/10.18017/iuitfd.279886   IUP :https://doi.org/10.18017/iuitfd.279886    Full Text (PDF)

TWO DIFFERENT PATIENTS WITH SAME GENETIC MAKE-UP: RISPERIDONE INTOXICATION IN MONOZYGOTIC TWINS - CASE REPORT

Metin UysalolSinem Oral CebeciZeynep Güneş Özinal

Intoxication among children is frequently observed among patients visiting pediatric emergency clinics. Inappropriately taken dosages of frequently used drugs which have adverse effects are among remarkably frequent reasons of these visits. In this case report the focus is on 7-year-old monozygotic twins with no previous health problems, who came to the pediatric emergency clinic with a dystonic contraction complaint starting simultaneously in both of them. 

DOI :https://doi.org/10.18017/iuitfd.279886   IUP :https://doi.org/10.18017/iuitfd.279886    Full Text (PDF)

FARKLI İKİ HASTA AYNI GENETİK ÖZELLİKLER, MONOZİGOTİK İKİZLERDE RİSPERİDON İNTOKSİKASYONU: OLGU SUNUMU

Metin UysalolSinem Oral CebeciZeynep Güneş Özinal

Çocuk acil polikliniklere başvuru nedenleri arasında çocukluk yaş grubunda zehirlenmeler önemli yer tutmaktadır. Yaygın olarak kullanılan, istenmeyen etki olasılığı yüksek ilaçların uygunsuz kullanımı bu nedenler arasında dikkat çekecek sıklıktadır. Bu olgu sunumunda, aynı anda başlayan distonik kasılma şikayetiyle başvuran, öncesinde herhangi bir sağlık sorunu olmayan yedi yaşında monozigotik ikiz kardeşler sunulmuştur.


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References

  • 1. Erkal S, Şafak Ş, An evaluation of the poisoning accidents encountered in children aged 0-6 years in Kırıkkale. Turk J Pediatr 2006;48:294-300. google scholar
  • 2. Kahveci M., Çeltik C., Karasalihoğlu S., Acunaş B., Bir üniversite hastanesi acil servisine başvuran çocukluk çağı zehirlenmelerinin değerlendirilmesi. Sürekli Tıp Eğitimi Dergisi 2004;13:19-21. google scholar
  • 3. Güzel IŞ, Kibar AE., Vidinlisan S, Çocuk acil servisine başvuran zehirlenme olgularının demografik özelliklerinin incelenmesi. Genel Tıp Derg 2011;21(3): 101-7. google scholar
  • 4. Ağın H, Çalkavur Ş, Olukman Ö, Ural R, Bak M, Çocukluk çağında zehirlenmelerin son 2 yıldaki olguların değerlendirilmesi. Turkiye Klinikleri J Pediatr 2002;11(4):186-93. google scholar
  • 5. Grant S, Fitton A, Risperidone--A review of its pharmacology and therapeutic potential in the treatment of schizophrenia. Drugs 1994;48:253-73. google scholar
  • 6. Persson HE., Sjöberg GK., Haines JA., Pronczuk de Garbino J., Poisoning severity score. Grading of acute poisoning. J Toxicol Clin Toxicol 1998;36:205-213. google scholar
  • 7. Oto GN., İkincioğulları D., Harmancı N., Ulusal Zehir Merkezine yapılan çocukluk çağı vaka başvurularının 5 yıllık retrospektif değerlendirilmesi. J Pediatr 2006;2:1-4. google scholar
  • 8. Teske J, Weller JP, Larsch K, Tröger HD, Karst M, Fatal outcome in a child after ingestion of a transdermal fentanyl patch. Int J Legal Med 2007;121:147–51. google scholar
  • 9. Livingston MG, Risperidone. Lancet 1994;343:457- 60. google scholar
  • 10. Laurence L. Brunton, John S. Lazo, Boldessarini RJ, Tarazi FI, Goodman and Gilman's The Pharmacological Basis of Therapeutics: Digital Edition, 11th E. McGraw-Hill Companies, Inc., New York, NY 2006;476. google scholar
  • 11.Burton Michael E., Applied Pharmacokinetics & Pharmacodynamics: Principles of Therapeutic Drug Monitoring 4th ed. Lippincott Williams&Wilkins 2006;832. google scholar
  • 12. Prescribing Information: Risperdal (risperidone). Janssen Pharmaceuticals 1994. google scholar
  • 13. Heather GS, Vicas IM, Risperidone overdose: A case series. Vet Hum Toxicol 1994;36:371. google scholar
  • 14. Kuspis D, Dean B, Krenzelok EP, Risperidone overdose assessment. J Clin Toxico1 1995;33:552. google scholar
  • 15. Katzung BG., Trevor AJ., Masters SB., DeBattista C. Basic and Clinical Pharmacology, Antipsychotic Agents&Lithium, 13th Ed. Mc Graw-Hill 2015;978. google scholar
  • 16. Tozer TN, Rowland M, Introduction to Pharmacokinetics and Pharmacodynamics: The Quantitative basis of drug therapy, Variability, Lippincot Williams Wilkins 2006;225 google scholar
  • 17. Swen JJ., Nijenhuis M., de Boer A., Grandia L., Maitland-van der Zee AH., Mulder H., et al. Pharmacogenetics: from bench to byte--an update of guidelines. Clin Pharmacol Ther 2011;89(5):662-73. doi: 10.1038/clpt.2011.34. google scholar
  • 18. Meyer UA, The molecular basis of genetic polymorphisms of drug metabolism. Journal of Pharmacy and Pharmacology 1994;46: 409-15. google scholar
  • 19.Jordan, J, Brabant G, Brinsuk M, Tank J, Horn R, Luft FC, Busjahn A, Heritability of free and receptor-bound leptin in normal twins. Am. J. Physiol. Regul. Integr. Comp. Physiol 2005;288:1411–6. google scholar
  • 20.Rasmussen B.B., Brix T.H., Kyvik, K.O. & Brøsen, K. The interindividual differences in the 3- demethylation of caffeine alias CYP1A2 is determined by both genetic and environmental factors. Pharmacogenetics 2002;12:473–8. google scholar

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APA

Uysalol, M., Oral Cebeci, S., & Güneş Özinal, Z. (2016). TWO DIFFERENT PATIENTS WITH SAME GENETIC MAKE-UP: RISPERIDONE INTOXICATION IN MONOZYGOTIC TWINS - CASE REPORT. Journal of Istanbul Faculty of Medicine, 79(3), 133-135. https://doi.org/https://doi.org/10.18017/iuitfd.279886


AMA

Uysalol M, Oral Cebeci S, Güneş Özinal Z. TWO DIFFERENT PATIENTS WITH SAME GENETIC MAKE-UP: RISPERIDONE INTOXICATION IN MONOZYGOTIC TWINS - CASE REPORT. Journal of Istanbul Faculty of Medicine. 2016;79(3):133-135. https://doi.org/https://doi.org/10.18017/iuitfd.279886


ABNT

Uysalol, M.; Oral Cebeci, S.; Güneş Özinal, Z. TWO DIFFERENT PATIENTS WITH SAME GENETIC MAKE-UP: RISPERIDONE INTOXICATION IN MONOZYGOTIC TWINS - CASE REPORT. Journal of Istanbul Faculty of Medicine, [Publisher Location], v. 79, n. 3, p. 133-135, 2016.


Chicago: Author-Date Style

Uysalol, Metin, and Sinem Oral Cebeci and Zeynep Güneş Özinal. 2016. “TWO DIFFERENT PATIENTS WITH SAME GENETIC MAKE-UP: RISPERIDONE INTOXICATION IN MONOZYGOTIC TWINS - CASE REPORT.” Journal of Istanbul Faculty of Medicine 79, no. 3: 133-135. https://doi.org/https://doi.org/10.18017/iuitfd.279886


Chicago: Humanities Style

Uysalol, Metin, and Sinem Oral Cebeci and Zeynep Güneş Özinal. TWO DIFFERENT PATIENTS WITH SAME GENETIC MAKE-UP: RISPERIDONE INTOXICATION IN MONOZYGOTIC TWINS - CASE REPORT.” Journal of Istanbul Faculty of Medicine 79, no. 3 (Aug. 2025): 133-135. https://doi.org/https://doi.org/10.18017/iuitfd.279886


Harvard: Australian Style

Uysalol, M & Oral Cebeci, S & Güneş Özinal, Z 2016, 'TWO DIFFERENT PATIENTS WITH SAME GENETIC MAKE-UP: RISPERIDONE INTOXICATION IN MONOZYGOTIC TWINS - CASE REPORT', Journal of Istanbul Faculty of Medicine, vol. 79, no. 3, pp. 133-135, viewed 14 Aug. 2025, https://doi.org/https://doi.org/10.18017/iuitfd.279886


Harvard: Author-Date Style

Uysalol, M. and Oral Cebeci, S. and Güneş Özinal, Z. (2016) ‘TWO DIFFERENT PATIENTS WITH SAME GENETIC MAKE-UP: RISPERIDONE INTOXICATION IN MONOZYGOTIC TWINS - CASE REPORT’, Journal of Istanbul Faculty of Medicine, 79(3), pp. 133-135. https://doi.org/https://doi.org/10.18017/iuitfd.279886 (14 Aug. 2025).


MLA

Uysalol, Metin, and Sinem Oral Cebeci and Zeynep Güneş Özinal. TWO DIFFERENT PATIENTS WITH SAME GENETIC MAKE-UP: RISPERIDONE INTOXICATION IN MONOZYGOTIC TWINS - CASE REPORT.” Journal of Istanbul Faculty of Medicine, vol. 79, no. 3, 2016, pp. 133-135. [Database Container], https://doi.org/https://doi.org/10.18017/iuitfd.279886


Vancouver

Uysalol M, Oral Cebeci S, Güneş Özinal Z. TWO DIFFERENT PATIENTS WITH SAME GENETIC MAKE-UP: RISPERIDONE INTOXICATION IN MONOZYGOTIC TWINS - CASE REPORT. Journal of Istanbul Faculty of Medicine [Internet]. 14 Aug. 2025 [cited 14 Aug. 2025];79(3):133-135. Available from: https://doi.org/https://doi.org/10.18017/iuitfd.279886 doi: https://doi.org/10.18017/iuitfd.279886


ISNAD

Uysalol, Metin - Oral Cebeci, Sinem - Güneş Özinal, Zeynep. TWO DIFFERENT PATIENTS WITH SAME GENETIC MAKE-UP: RISPERIDONE INTOXICATION IN MONOZYGOTIC TWINS - CASE REPORT”. Journal of Istanbul Faculty of Medicine 79/3 (Aug. 2025): 133-135. https://doi.org/https://doi.org/10.18017/iuitfd.279886



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